Conjunctival effects of canine distemper virus-induced keratoconjunctivitis sicca

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dc.contributor.authorde Almeida, Denize E.
dc.contributor.authorRoveratti, Cristina [UNESP]
dc.contributor.authorBrito, Fabio L. C.
dc.contributor.authorGodoy, Guilherme S.
dc.contributor.authorDuque, Juan C. M.
dc.contributor.authorBechara, Gervasio Henrique [UNESP]
dc.contributor.authorLaus, Jose L. [UNESP]
dc.contributor.institutionUniversity of Michigan
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Rural Fed Pernambuco
dc.contributor.institutionCtr Univ Monte Serrat
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2014-05-20T13:14:13Z
dc.date.available2014-05-20T13:14:13Z
dc.date.issued2009-07-01
dc.description.abstractObjectiveThis study compared the histopathology of canine distemper virus (CDV)-induced keratoconjunctivitis sicca (KCS) to non-infectious KCS in conjunctival tissues.Animals studiedForty mongrel dogs were assigned to three distinct groups: (i) non-infectious KCS (G1, n = 10), (ii) CDV-induced KCS (G2, n = 20), and (iii) healthy animals without any ocular alterations (G3, n = 10).ProcedureIgG titers and physical and ophthalmic examinations (e.g. Schirmer tear test [STT], tonometry, biomicroscopy, indirect biomicroscopy, and fluorescein test) were performed on all dogs. Conjunctival biopsies were collected and examined microscopically.ResultsNon-infectious and CDV-induced KCS demonstrated similar histopathological changes. Both types of KCS correlated with low STT, conjunctival hyperemia, mucopurulent ocular discharge, predominant lymphoplasmacytic infiltration, and acantholysis and keratinization of the ocular surface. G1 had lower conjunctival goblet cell counts than G3. Inclusion bodies were sporadically found in conjunctival samples of dogs from G2. The severity of ocular lesions in G1 and G2 did not correlate with the histopathological findings.ConclusionsDogs with non-infectious and CDV-induced KCS had very similar conjunctival histopathology. Our findings suggest that the pathophysiology of CDV-induced KCS is likely to be the same as non-infectious KCS, that is, a result of lacrimal deficiency and inflammation of the ocular surface.en
dc.description.affiliationUniv Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA
dc.description.affiliationUniv Estadual Paulista, Dept Vet Clin & Surg, Jaboticabal, SP, Brazil
dc.description.affiliationUniv Rural Fed Pernambuco, Dept Vet Med, Garanhuns, PE, Brazil
dc.description.affiliationCtr Univ Monte Serrat, Dept Vet Med, Santos, SP, Brazil
dc.description.affiliationUniversidade Federal de Goiás (UFG), Dept Vet Med, Goiania, Go, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Vet Pathol, Jaboticabal, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Vet Clin & Surg, Jaboticabal, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Vet Pathol, Jaboticabal, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 04/04700-8
dc.format.extent211-215
dc.identifierhttp://dx.doi.org/10.1111/j.1463-5224.2009.00699.x
dc.identifier.citationVeterinary Ophthalmology. Malden: Wiley-blackwell Publishing, Inc, v. 12, n. 4, p. 211-215, 2009.
dc.identifier.doi10.1111/j.1463-5224.2009.00699.x
dc.identifier.issn1463-5216
dc.identifier.lattes2382374201685423
dc.identifier.urihttp://hdl.handle.net/11449/1753
dc.identifier.wosWOS:000267756800002
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing, Inc
dc.relation.ispartofVeterinary Ophthalmology
dc.relation.ispartofjcr1.083
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectconjunctivaeen
dc.subjectdistemperen
dc.subjectDogen
dc.subjectInflammationen
dc.subjectkeratoconjunctivitis siccaen
dc.subjectmorbillivirusen
dc.titleConjunctival effects of canine distemper virus-induced keratoconjunctivitis siccaen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell Publishing, Inc
unesp.author.lattes2382374201685423
unesp.author.orcid0000-0003-4619-3744[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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