In vitro and in vivo cytotoxicity assessment of glyphosate and imazethapyr-based herbicides and their association

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dc.contributor.authorCosta, Gessyca
dc.contributor.authorFernandes, Andréia
dc.contributor.authorSantos, Thaís
dc.contributor.authorBrito, Lara
dc.contributor.authorRodrigues, Laís
dc.contributor.authorValadares, Marize
dc.contributor.authorFelzenszwalb, Israel
dc.contributor.authorFerraz, Elisa [UNESP]
dc.contributor.authorMorais Leme, Daniela [UNESP]
dc.contributor.authorOliveira, Gisele [UNESP]
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionState University of Rio de Janeiro
dc.contributor.institutionFluminense Federal University
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFederal University of Paraná
dc.date.accessioned2022-04-28T19:51:19Z
dc.date.available2022-04-28T19:51:19Z
dc.date.issued2022-01-01
dc.description.abstractResistance to glyphosate herbicide has initiated usage of combined application of herbicides as a weed control measure. Imazethapyr-based herbicides associated with glyphosate herbicide seem to be an alternative to suppress weed resistance. The aim of this study was to examine the adverse effects of Glyphosate Atanor 48® (ATN) and Imazethapyr Plus Nortox® (IMZT) formulations in both single forms and mixtures using HepG2 cells and zebrafish early-life stages models. Data demonstrated cytotoxicity due to exposure to ATN, IMZT for both models, as follows: (1) ATN (0.5 mg/L), IMZT (5 mg/L), and M3 (0.05 mg/L ATN + 5 mg/L IMZT) increased cytotoxicity by disturbing the mitochondrial activity of HepG2 cells 24 hr after exposure; (2) ATN and IMZT (5 mg/L), and M3 (0.05 mg/L ATN + 5 mg/L IMZT) also decreased the integrity of the membrane of HepG2 cells after 24 hr incubation; (3) only ATN and IMZT (5 mg/L) in their single forms diminished the mitochondrial potential of zebrafish; (4) ATN (single form) at 0.5 mg/L induced apoptosis in zebrafish larvae. In conclusion, these herbicides in their single forms appeared to produce greater cytotoxicity to HepG2 cells and zebrafish compared to the herbicide mixtures.en
dc.description.affiliationEnvironmental Toxicology Research Laboratory Faculty of Pharmacy Federal University of Goiás
dc.description.affiliationDepartment of Biophysics and Biometry Institute of Biology Roberto Alcantara Gomes State University of Rio de Janeiro
dc.description.affiliationLaboratory of Teaching and Research in Toxicology in Vitro Faculty of Pharmacy Federal University of Goiás
dc.description.affiliationDepartment of Pharmacy and Pharmaceutical Administration Pharmacy College Fluminense Federal University
dc.description.affiliationInstitute of Chemistry National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives UNESP
dc.description.affiliationDepartament of Genetics Federal University of Paraná
dc.description.affiliationUnespInstitute of Chemistry National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives UNESP
dc.identifierhttp://dx.doi.org/10.1080/15287394.2022.2036281
dc.identifier.citationJournal of Toxicology and Environmental Health - Part A: Current Issues.
dc.identifier.doi10.1080/15287394.2022.2036281
dc.identifier.issn1087-2620
dc.identifier.issn1528-7394
dc.identifier.scopus2-s2.0-85125470190
dc.identifier.urihttp://hdl.handle.net/11449/223540
dc.language.isoeng
dc.relation.ispartofJournal of Toxicology and Environmental Health - Part A: Current Issues
dc.sourceScopus
dc.subjectcytotoxicity
dc.subjectFormulations
dc.subjectHepG2
dc.subjectmixtures
dc.subjectzebrafish
dc.titleIn vitro and in vivo cytotoxicity assessment of glyphosate and imazethapyr-based herbicides and their associationen
dc.typeArtigo
unesp.author.orcid0000-0002-0379-1325[6]
unesp.author.orcid0000-0001-7164-1276[9]
unesp.author.orcid0000-0002-0758-2707[10]

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