Multi-walled carbon nanotubes modified screen-printed electrodes for cisplatin detection

dc.contributor.authorMateron, Elsa M. [UNESP]
dc.contributor.authorWong, Ademar [UNESP]
dc.contributor.authorKlein, Stanlei I. [UNESP]
dc.contributor.authorLiu, Juewen
dc.contributor.authorSotomayor, Maria D. P. T. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Waterloo
dc.description.abstractA screen printed electrode functionalized with multi-walled carbon nanotubes and factory modified with carboxyl groups (MWCNT-COOH/SPCEs) was characterized by cyclic voltammetry and differential pulse voltammetry in a NaCl (0.1 mol L-1, pH 7) solution containing 800 mu mol L-1 sodium dodecyl sulfate (SDS). The MWCNT-COOH/SDS/SPCEs sensor was tested for the detection and quantification of cisplatin. For solutions of cisplatin, the electrochemical analysis showed a linear correlation coefficient of 0.9974 to cisplatin at concentrations between 1.45 x 10(-5) and 1.0 x 10(-4) mol L-1, a sensitivity of 4.4 x 10(4) (+/- 1.0 x 10(3)) mu A L mol(-1), and detection and quantification limits of 4.6 x 10(-6) and 1.4 x 10(-5) mol L-1, respectively. The reproducibility of the sensor response evaluated by the analysis of three replicates, indicated a RSD of 3.91%. The excellent response of the MWCNT-COOH/SDS/SPCEs cisplatin sensor allowed it to be tested in samples of human blood serum whose levels of added cisplatin were monitored by the HPLC. The average error % (sensor/HPLC) of 3.4 indicates that the combined methodology of MWCNT-COOH modified SPCE and the addition of a surfactant such as dodecyl sulfate is a convenient alternative for the use of HPLC for cisplatin determination in biological samples. The methodology cannot be applied to non-ionizable antitumor drugs carboplatin, oxaliplatin, doxorubicin or gemcitabine. (C) 2015 Elsevier Ltd. All rights reserved.en
dc.description.affiliationDepartment of Chemistry and Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1
dc.description.affiliationUnespDepartment of Analytical Chemistry, Institute of Chemistry, State University of São Paulo (UNESP), 14801-970, Araraquara – SP, Brazil
dc.description.affiliationUnespDepartment of Inorganic Chemistry, Institute of Chemistry, State University of São Paulo (UNESP), 14801-970, Araraquara – SP, Brazil.
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.identifier.citationElectrochimica Acta. Oxford: Pergamon-elsevier Science Ltd, v. 158, p. 271-276, 2015.
dc.publisherElsevier B.V.
dc.relation.ispartofElectrochimica Acta
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectScreen printed electrodeen
dc.subjectMulti-walled carbon nanotubes (MWCNT-COOH)en
dc.subjectSodium dodecyl sulphate (SDS)en
dc.subjectDifferential pulse voltammetryen
dc.titleMulti-walled carbon nanotubes modified screen-printed electrodes for cisplatin detectionen
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt