Gender, body mass index and rheumatoid arthritis disease activity: Results from the QUEST-RA study

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dc.contributor.authorJawaheer, Damini
dc.contributor.authorOlsen, Jørn
dc.contributor.authorLahiff, Maureen
dc.contributor.authorForsberg, Sinikka
dc.contributor.authorLähteenmäki, Jukka
dc.contributor.authorda Silveira, Ines Guimaraes
dc.contributor.authorRocha, Francisco Airton
dc.contributor.authorLaurindo, Ieda Maria Magalhães [UNESP]
dc.contributor.authorda Mota, Licia Maria Henrique
dc.contributor.authorDrosos, Alexandros A.
dc.contributor.authorMurphy, Eithne
dc.contributor.authorSheehy, Claire
dc.contributor.authorQuirke, Edel
dc.contributor.authorCutolo, Maurizio
dc.contributor.authorRexhepi, Sylejman
dc.contributor.authorDadoniene, Jolanta
dc.contributor.authorVerstappen, Suzan M.M.
dc.contributor.authorSokka, Tuulikki
dc.contributor.authorToloza, Sergio
dc.contributor.authorAguero, Santiago
dc.contributor.authorBarrera, Sergio Orellana
dc.contributor.authorRetamozo, Soledad
dc.contributor.authorAlba, Paula
dc.contributor.authorLascano, Cruz
dc.contributor.authorBabini, Alejandra
dc.contributor.authorAlbiero, Eduardo
dc.contributor.authorPinheiro, Geraldo da Rocha Castelar
dc.contributor.authorLazovskis, Juris
dc.contributor.authorHetland, Merete Lund
dc.contributor.authorØrnbjerg, Lykke
dc.contributor.authorHørslev-Petersen, Kim
dc.contributor.authorHansen, Troels Mørk
dc.contributor.authorKnudsen, Lene Surland
dc.contributor.authorHamoud, Hisham
dc.contributor.authorSobhy, Mohamad
dc.contributor.authorFahmy, Ahmad
dc.contributor.authorMagdy, Mohamad
dc.contributor.authorAly, Hany
dc.contributor.authorSaeid, Hatem
dc.contributor.authorNagm, Ahmad
dc.contributor.authorFathi, Nihal A.
dc.contributor.authorAbda, Esam
dc.contributor.authorEbraheam, Zahra
dc.contributor.authorMüller, Raili
dc.contributor.authorKuuse, Reet
dc.contributor.authorTammaru, Marika
dc.contributor.authorKallikorm, Riina
dc.contributor.authorPeets, Tony
dc.contributor.authorOtsa, Kati
dc.contributor.authorLaas, Karin
dc.contributor.authorValter, Ivo
dc.contributor.authorMäkinen, Heidi
dc.contributor.authorImmonen, Kai
dc.contributor.authorLuukkainen, Reijo
dc.contributor.authorGossec, Laure
dc.contributor.authorDougados, Maxime
dc.contributor.authorMaillefert, Jean Francis
dc.contributor.authorCombe, Bernard
dc.contributor.authorSibilia, Jean
dc.contributor.authorExarchou, Sofia
dc.contributor.authorMoutsopoulos, H. M.
dc.contributor.authorTsirogianni, Afrodite
dc.contributor.authorSkopouli, Fotini N.
dc.contributor.authorMavrommati, Maria
dc.contributor.authorHerborn, Gertraud
dc.contributor.authorRau, Rolf
dc.contributor.authorAlten, Rieke
dc.contributor.authorPohl, Christof
dc.contributor.authorBurmester, Gerd R.
dc.contributor.authorMarsmann, Bettina
dc.contributor.authorGéher, Pál
dc.contributor.authorRojkovich, Bernadette
dc.contributor.authorBresnihan, Barry
dc.contributor.authorMinnock, Patricia
dc.contributor.authorDevlin, Joe
dc.contributor.authorAlraqi, Shafeeq
dc.contributor.authorAggarwal, Amita
dc.contributor.authorPandya, Sapan
dc.contributor.authorSharma, Banwari
dc.contributor.authorCazzato, Massimiliano
dc.contributor.authorBombardieri, Stefano
dc.contributor.authorFerraccioli, Gianfranco
dc.contributor.authorMorelli, Alessia
dc.contributor.authorSalaffi, Fausto
dc.contributor.authorStancati, Andrea
dc.contributor.authorYamanaka, Hisashi
dc.contributor.authorNakajima, Ayako
dc.contributor.authorFukuda, Wataru
dc.contributor.authorShono, Eisuke
dc.contributor.authorOyoo, Omondi
dc.contributor.authorRexhepi, Mjellma
dc.contributor.authorAndersone, Daina
dc.contributor.authorStropuviene, Sigita
dc.contributor.authorBaranauskaite, Asta
dc.contributor.authorHajjaj-Hassouni, Naija
dc.contributor.authorBenbouazza, Karima
dc.contributor.authorAllali, Fadoua
dc.contributor.authorBahiri, Rachid
dc.contributor.authorAmine, Bouchra
dc.contributor.authorJacobs, Johannes W.G.
dc.contributor.authorHuisman, Margriet
dc.contributor.authorHoekstra, Monique
dc.contributor.authorHaugeberg, Glenn
dc.contributor.authorGjelberg, Hilde
dc.contributor.authorSierakowski, Stanislaw
dc.contributor.authorMajdan, Maria
dc.contributor.authorRomanowski, Wojciech
dc.contributor.authorTlustochowicz, Witold
dc.contributor.authorKapolka, Danuta
dc.contributor.authorSadkiewicz, Stefan
dc.contributor.authorZarowny-Wierzbinska, Danuta
dc.contributor.authorIonescu, Ruxandra
dc.contributor.authorPredeteanu, Denisa
dc.contributor.authorKarateev, Dmitry
dc.contributor.authorLuchikhina, Elena
dc.contributor.authorChichasova, Natalia
dc.contributor.authorBadokin, Vladimir
dc.contributor.authorSkakic, Vlado
dc.contributor.authorDimic, Aleksander
dc.contributor.authorNedovic, Jovan
dc.contributor.authorStankovic, Aleksandra
dc.contributor.authorNaranjo, Antonio
dc.contributor.authorRodríguez-Lozano, Carlos
dc.contributor.authorCalvo-Alen, Jaime
dc.contributor.authorBelmonte, Miguel
dc.contributor.authorBaecklund, Eva
dc.contributor.authorHenrohn, Dan
dc.contributor.authorOding, Rolf
dc.contributor.authorLiveborn, Margareth
dc.contributor.authorHolmqvist, Ann-Carin
dc.contributor.authorGogus, Feride
dc.contributor.authorTunc, Recep
dc.contributor.authorCelic, Selda
dc.contributor.authorBadsha, Humeira
dc.contributor.authorMofti, Ayman
dc.contributor.authorTaylor, Peter
dc.contributor.authorMcClinton, Catherine
dc.contributor.authorWoolf, Anthony
dc.contributor.authorChorghade, Ginny
dc.contributor.authorChoy, Ernest
dc.contributor.authorKelly, Stephen
dc.contributor.authorPincus, Theodore
dc.contributor.authorYazici, Yusuf
dc.contributor.authorBergman, Martin
dc.contributor.authorCraig-Muller, Jurgen
dc.contributor.authorKautiainen, Hannu
dc.contributor.authorSwearingen, Christopher
dc.contributor.institutionUniversity of California Los Angeles
dc.contributor.institutionUniversity of California Berkeley
dc.contributor.institutionNorth Karelia Central Hospital
dc.contributor.institutionPontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
dc.contributor.institutionUniversidade Federal do Ceará
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionHospital Universitário de Brasília
dc.contributor.institutionUniversity of Ioannina Ioannina
dc.contributor.institutionWaterford Regional Hospital
dc.contributor.institutionConnolly Hospital
dc.contributor.institutionUniversity of Genova
dc.contributor.institutionRheumatology Department
dc.contributor.institutionVilnius University
dc.contributor.institutionUniversity Medical Centre Utrecht
dc.contributor.institutionJyväskylä Central Hospital
dc.contributor.institutionMedcare Oy
dc.contributor.institutionHospital Oakland Research Institute
dc.contributor.institutionHospital San Juan Bautista
dc.contributor.institutionHospital of Cordoba
dc.contributor.institutionUniversidade do Estado do Rio de Janeiro (UERJ)
dc.contributor.institutionRiverside Professional Centre
dc.contributor.institutionCopenhagen University Hospital at Hvidovre
dc.contributor.institutionKing Christian the Xth Hospital
dc.contributor.institutionCopenhagen University Hospital at Herlev
dc.contributor.institutionAl-Azhar University
dc.contributor.institutionAssiut University Hospital
dc.contributor.institutionAbo Sohage University Hospital
dc.contributor.institutionTartu University Hospital
dc.contributor.institutionEast-Tallinn Central Hospital
dc.contributor.institutionCentre for Clinical and Basic Research
dc.contributor.institutionSatakunta Central Hospital
dc.contributor.institutionHôpital Cochin
dc.contributor.institutionINSERM U887
dc.contributor.institutionHôpital Lapeyronie
dc.contributor.institutionHôpital Hautepierre
dc.contributor.institutionNational University of Athens
dc.contributor.institutionEuroclinic Hospital
dc.contributor.institutionEvangelisches Fachkrankenhaus
dc.contributor.institutionSchlosspark-Klinik
dc.contributor.institutionUniversity Medicine Berlin
dc.contributor.institutionSemmelweis University of Medical Sciences
dc.contributor.institutionPolyclinic of the Hospitaller Brothers of St. John of God in Budapest
dc.contributor.institutionSt. Vincent University Hospital
dc.contributor.institutionOur Lady's Hospice
dc.contributor.institutionVedanta Institiute of Medical Sciences
dc.contributor.institutionJaipur Hospital
dc.contributor.institutionSanta Chiara Hospital
dc.contributor.institutionCatholic University of Sacred Heart
dc.contributor.institutionUniversity of Ancona
dc.contributor.institutionTokyo Women's Medical University
dc.contributor.institutionKyoto First Red Cross Hospital
dc.contributor.institutionShono Rheumatism Clinic
dc.contributor.institutionKenyatta Hospital
dc.contributor.institutionPauls Stradina Clinical University Hospital
dc.contributor.institutionKaunas University Hospital
dc.contributor.institutionEl Ayachi Hospital Mohamed Vth Souissi University
dc.contributor.institutionSint Franciscus Gasthuis Hospital
dc.contributor.institutionMedisch Spectrum Twente
dc.contributor.institutionSørlandet Hospital
dc.contributor.institutionMedical University in Bialystok
dc.contributor.institutionMedical University of Lublin
dc.contributor.institutionPoznan Rheumatology Centre in Srem
dc.contributor.institutionMilitary Institute of Medicine
dc.contributor.institutionSilesian Hospital for Rheumatology and Rehabilitation in Ustron Slaski
dc.contributor.institutionSzpital Wojewodzki im. Jana Biziela
dc.contributor.institutionWojewodzki Zespol Reumatologiczny im. dr Jadwigi Titz-Kosko
dc.contributor.institutionSpitalul Clinic Sf Maria
dc.contributor.institutionInstitute of Rheumatology of Russian Academy of Medical Sciences
dc.contributor.institutionMoscow Medical Academy
dc.contributor.institutionRussian Medical Academy of Postgraduate Education
dc.contributor.institutionRheumatology Institut
dc.contributor.institutionHospital de Gran Canaria Dr. Negrin
dc.contributor.institutionHospital Sierrallana Ganzo
dc.contributor.institutionHospital General de Castellón
dc.contributor.institutionUppsala University Hospital
dc.contributor.institutionCentrallasarettet
dc.contributor.institutionHudiksvall Medical Clinic
dc.contributor.institutionGazi University Medical Faculty
dc.contributor.institutionMeram Medical Faculty
dc.contributor.institutionCerrahpasa Medic Faculty
dc.contributor.institutionDubai Bone and Joint Centre
dc.contributor.institutionAmerican Hospital Dubai
dc.contributor.institutionCharing Cross Hospital
dc.contributor.institutionRoyal Cornwall Hospital
dc.contributor.institutionKings College Hospital
dc.contributor.institutionVanderbilt University
dc.contributor.institutionNYU Hospital for Joint Diseases
dc.contributor.institutionTaylor Hospital
dc.contributor.institutionCentra Care Clinic
dc.contributor.institutionUniversity of Arkansas for Medical Sciences
dc.contributor.institutionNew York University Hospital for Joint Diseases
dc.date.accessioned2022-04-28T18:56:40Z
dc.date.available2022-04-28T18:56:40Z
dc.date.issued2010-12-01
dc.description.abstractObjective: To investigate whether body mass index (BMI), as a proxy for body fat, influences rheumatoid arthritis (RA) disease activity in a gender-specific manner. Methods: Consecutive patients with RA were enrolled from 25 countries into the QUEST-RA program between 2005 and 2008. Clinical and demographic data were collected by treating rheumatologists and by patient self-report. Distributions of Disease Activity Scores (DAS28), BMI, age, and disease duration were assessed for each country and for the entire dataset; mean values between genders were compared using Student's t-tests. An association between BMI and DAS28 was investigated using linear regression, adjusting for age, disease duration and country. Results: A total of 5,161 RA patients (4,082 women and 1,079 men) were included in the analyses. Overall, women were younger, had longer disease duration, and higher DAS28 scores than men, but BMI was similar between genders. The mean DAS28 scores increased with increasing BMI from normal to overweight and obese, among women, whereas the opposite trend was observed among men. Regression results showed BMI (continuous or categorical) to be associated with DAS28. Compared to the normal BMI range, being obese was associated with a larger difference in mean DAS28 (0.23, 95% CI: 0.11, 0.34) than being overweight (0.12, 95% CI: 0.03, 0.21); being underweight was not associated with disease activity. These associations were more pronounced among women, and were not explained by any single component of the DAS28. Conclusion: BMI appears to be associated with RA disease activity in women, but not in men. © Copyright Clinical and Experimental Rheumatology 2010.en
dc.description.affiliationUniversity of California Los Angeles, Los Angeles, CA
dc.description.affiliationUniversity of California Berkeley, Berkeley, CA
dc.description.affiliationNorth Karelia Central Hospital, Joensuu
dc.description.affiliationPontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre
dc.description.affiliationUniversidade Federal do Ceará, Fortaleza
dc.description.affiliationUniversidade Estadual de São Paulo, São Paulo
dc.description.affiliationHospital Universitário de Brasília, Brasilia
dc.description.affiliationUniversity of Ioannina Ioannina
dc.description.affiliationWaterford Regional Hospital, Waterford
dc.description.affiliationConnolly Hospital, Dublin
dc.description.affiliationUniversity of Genova, Genova
dc.description.affiliationRheumatology Department, Pristine
dc.description.affiliationInstitute of Experimental and Clinical Medicine Vilnius University, Vilnius
dc.description.affiliationUniversity Medical Centre Utrecht, Utrecht
dc.description.affiliationJyväskylä Central Hospital, Jyväskylä
dc.description.affiliationMedcare Oy, Äänekoski
dc.description.affiliationHospital Oakland Research Institute, Oakland, CA
dc.description.affiliationHospital San Juan Bautista, Catamarca
dc.description.affiliationHospital of Cordoba, Cordoba
dc.description.affiliationUniversidade do Estado do Rio de Janeiro, Rio de Janeiro
dc.description.affiliationRiverside Professional Centre, Sydney, NS
dc.description.affiliationCopenhagen University Hospital at Hvidovre, Hvidovre
dc.description.affiliationKing Christian the Xth Hospital, Gråsten
dc.description.affiliationCopenhagen University Hospital at Herlev, Herlev
dc.description.affiliationAl-Azhar University, Cairo
dc.description.affiliationAssiut University Hospital, Assiut
dc.description.affiliationAbo Sohage University Hospital, Sohage
dc.description.affiliationTartu University Hospital, Tartu
dc.description.affiliationEast-Tallinn Central Hospital, Tallinn
dc.description.affiliationCentre for Clinical and Basic Research, Tallinn
dc.description.affiliationSatakunta Central Hospital, Rauma
dc.description.affiliationUniversity René Descartes Hôpital Cochin, Paris
dc.description.affiliationDijon University Hospital University of Burgundy INSERM U887, Dijon
dc.description.affiliationHôpital Lapeyronie, Montpellier
dc.description.affiliationHôpital Hautepierre, Strasbourg
dc.description.affiliationSchool of Medicine National University of Athens, Athens
dc.description.affiliationEuroclinic Hospital, Athens
dc.description.affiliationEvangelisches Fachkrankenhaus, Ratingen
dc.description.affiliationSchlosspark-Klinik, Berlin
dc.description.affiliationUniversity Medicine Berlin, Berlin
dc.description.affiliationSemmelweis University of Medical Sciences, Budapest
dc.description.affiliationIlona Újfalussy Polyclinic of the Hospitaller Brothers of St. John of God in Budapest, Budapest
dc.description.affiliationSt. Vincent University Hospital, Dublin
dc.description.affiliationOur Lady's Hospice, Dublin
dc.description.affiliationDepartment of Immunology, Lucknow
dc.description.affiliationVedanta Institiute of Medical Sciences, Ahmedabad
dc.description.affiliationDepartment of Immunology Jaipur Hospital
dc.description.affiliationSanta Chiara Hospital, Pisa
dc.description.affiliationCatholic University of Sacred Heart, Rome
dc.description.affiliationUniversity of Ancona, Ancona
dc.description.affiliationInstitute of Rheumatology Tokyo Women's Medical University, Tokyo
dc.description.affiliationDepartment of Rheumatology Kyoto First Red Cross Hospital, Kyoto
dc.description.affiliationShono Rheumatism Clinic, Fukuoka
dc.description.affiliationKenyatta Hospital, Nairobi
dc.description.affiliationPauls Stradina Clinical University Hospital, Riga
dc.description.affiliationKaunas University Hospital, Kaunas
dc.description.affiliationEl Ayachi Hospital Mohamed Vth Souissi University, Rabat
dc.description.affiliationSint Franciscus Gasthuis Hospital, Rotterdam
dc.description.affiliationMedisch Spectrum Twente, Enschede
dc.description.affiliationSørlandet Hospital, Kristiansand
dc.description.affiliationMedical University in Bialystok, Bialystok
dc.description.affiliationMedical University of Lublin, Lublin
dc.description.affiliationPoznan Rheumatology Centre in Srem, Srem
dc.description.affiliationMilitary Institute of Medicine, Warsaw
dc.description.affiliationSilesian Hospital for Rheumatology and Rehabilitation in Ustron Slaski, Ustroñ Slaski
dc.description.affiliationSzpital Wojewodzki im. Jana Biziela, Bydgoszcz
dc.description.affiliationWojewodzki Zespol Reumatologiczny im. dr Jadwigi Titz-Kosko, Sopot
dc.description.affiliationSpitalul Clinic Sf Maria, Bucharest
dc.description.affiliationInstitute of Rheumatology of Russian Academy of Medical Sciences, Moscow
dc.description.affiliationMoscow Medical Academy, Moscow
dc.description.affiliationRussian Medical Academy of Postgraduate Education, Moscow
dc.description.affiliationRheumatology Institut, Niska Banja
dc.description.affiliationHospital de Gran Canaria Dr. Negrin, Las Palmas
dc.description.affiliationHospital Sierrallana Ganzo, Torrelavega
dc.description.affiliationHospital General de Castellón, Castellón
dc.description.affiliationUppsala University Hospital, Uppsala
dc.description.affiliationCentrallasarettet, Västerås
dc.description.affiliationHudiksvall Medical Clinic, Hudiksvall
dc.description.affiliationGazi University Medical Faculty, Ankara
dc.description.affiliationMeram Medical Faculty, Konya
dc.description.affiliationCerrahpasa Medic Faculty, Istanbul
dc.description.affiliationDubai Bone and Joint Centre, Dubai
dc.description.affiliationAmerican Hospital Dubai, Dubai
dc.description.affiliationCharing Cross Hospital, London
dc.description.affiliationRoyal Cornwall Hospital, Truro
dc.description.affiliationKings College Hospital, London
dc.description.affiliationVanderbilt University, Nashville, TN
dc.description.affiliationNYU Hospital for Joint Diseases, New York, NY
dc.description.affiliationTaylor Hospital, Ridley Park, PA
dc.description.affiliationCentra Care Clinic, St. Cloud, MN
dc.description.affiliationUniversity of Arkansas for Medical Sciences, Little Rock, AR
dc.description.affiliationNew York University Hospital for Joint Diseases, New York, NY
dc.description.affiliationUnespUniversidade Estadual de São Paulo, São Paulo
dc.format.extent454-461
dc.identifier.citationClinical and Experimental Rheumatology, v. 28, n. 4, p. 454-461, 2010.
dc.identifier.issn0392-856X
dc.identifier.issn1593-098X
dc.identifier.scopus2-s2.0-79952056556
dc.identifier.urihttp://hdl.handle.net/11449/219633
dc.language.isoeng
dc.relation.ispartofClinical and Experimental Rheumatology
dc.sourceScopus
dc.subjectBmi
dc.subjectDisease activity
dc.subjectGender
dc.subjectRheumatoid arthritis
dc.titleGender, body mass index and rheumatoid arthritis disease activity: Results from the QUEST-RA studyen
dc.typeArtigo

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