Synergistic effect of fluoride and sodium hexametaphosphate in toothpaste on enamel demineralization in situ

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dc.contributor.authorCamara, Danielle Mendes da[UNESP]
dc.contributor.authorPessan, Juliano Pelim [UNESP]
dc.contributor.authorFrancati, Tamires Melo [UNESP]
dc.contributor.authorSantos Souza, José Antonio [UNESP]
dc.contributor.authorDanelon, Marcelle [UNESP]
dc.contributor.authorDelbem, Alberto Carlos Botazzo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:32:17Z
dc.date.available2015-12-07T15:32:17Z
dc.date.issued2015
dc.description.abstractTo evaluate the effect of a fluoride dentifrice containing sodium hexametaphosphate (HMP) on enamel demineralization in situ. This double-blind and cross-over study consisted of 3 phases (7 days each) in which 12 volunteers wore intraoral appliances containing four enamel bovine blocks. Specimens were treated (3×/day) with placebo (no F or HMP), 1100ppm F (1100F) and 1100F plus HMP1% (1100F-HMP1%) toothpastes, and the cariogenic challenge was performed using a 30% sucrose solution (6×/day). Final surface hardness, the percentage of surface hardness loss (%SH), the integrated loss of subsurface hardness (ΔKHN), as well as enamel calcium (Ca), phosphorus (P) and firmly-bound fluoride (F) were determined. Also, biofilm formed on the blocks were analyzed for F, Ca, P and insoluble extracellular polysaccharide (EPS) concentrations. Data were submitted 1-way ANOVA, followed by Student-Newman-Keuls' test (p<0.05). 1100F-HMP1% promoted the lowest %SH and ΔKHN among all groups (p<0.001). The addition of HMP1% to 1100F did not enhance enamel F uptake, but significantly increased enamel Ca concentrations (p<0.001). Similar EPS concentrations were seen for 1100F-HMP1% and 1100F groups (p>0.05). All the groups were supersaturated with respect to HA. However, only 1100F-HMP1% group was supersaturated with respect to CaF2 (p<0.05). The ionic activities of F(-), CaF(+) and HF(0) for the 1100F-HMP1% group were the highest among all groups (p<0.001). The addition of HMP1% to a conventional toothpaste significantly reduces enamel demineralization in situ when compared to 1100F. This dentifrice could be a viable alternative to patients at high risk of caries.en
dc.description.affiliationAraçatuba Dental School, UNESP-Univ. Estadual Paulista, Department of Pediatric Dentistry and Public Health, R. José Bonifácio 1193, 16015-050 Araçatuba, SP, Brazil.
dc.description.affiliationAraçatuba Dental School, UNESP-Univ. Estadual Paulista, Department of Pediatric Dentistry and Public Health, R. José Bonifácio 1193, 16015-050 Araçatuba, SP, Brazil. Electronic address: adelbem@foa.unesp.br.
dc.description.affiliationUnespAraçatuba Dental School, UNESP-Univ. Estadual Paulista, Department of Pediatric Dentistry and Public Health, R. José Bonifácio 1193, 16015-050 Araçatuba, SP, Brazil.
dc.description.affiliationUnespAraçatuba Dental School, UNESP-Univ. Estadual Paulista, Department of Pediatric Dentistry and Public Health, R. José Bonifácio 1193, 16015-050 Araçatuba, SP, Brazil. Electronic address: adelbem@foa.unesp.br.
dc.format.extent1249-1254
dc.identifierhttp://dx.doi.org/10.1016/j.jdent.2015.08.007
dc.identifier.citationJournal Of Dentistry, v. 43, n. 10, p. 1249-1254, 2015.
dc.identifier.doi10.1016/j.jdent.2015.08.007
dc.identifier.issn1879-176X
dc.identifier.orcid0000-0002-8159-4853
dc.identifier.pubmed26299931
dc.identifier.urihttp://hdl.handle.net/11449/131175
dc.language.isoeng
dc.publisherElsevier B. V.
dc.relation.ispartofJournal Of Dentistry
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectDemineralizationen
dc.subjectDental enamelen
dc.subjectDentifricesen
dc.subjectFluoridesen
dc.subjectPolyphosphatesen
dc.titleSynergistic effect of fluoride and sodium hexametaphosphate in toothpaste on enamel demineralization in situen
dc.typeArtigo
dcterms.rightsHolderElsevier B. V.
unesp.author.lattes0421571920582994[5]
unesp.author.orcid0000-0002-8159-4853[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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Artigos - Odontologia Infantil e Social - FOA