Assessment of Gastrointestinal Motility in Renal Transplant Recipients by Alternate Current Biosusceptometry

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dc.contributor.authorTeixeira, M. C. B.
dc.contributor.authorMagalhaes, I.
dc.contributor.authorGalvao, P. V. M.
dc.contributor.authorSouza, G. S.
dc.contributor.authorMiranda, J. R A [UNESP]
dc.contributor.authorOliveira, R. B.
dc.contributor.authorCora, L. A.
dc.contributor.institutionFAMED Univ Estadual Ciencias Saúde Alagoas UNCISA
dc.contributor.institutionUTR Ctr Hosp Manoel Andre CHAMA
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T15:32:40Z
dc.date.available2014-05-20T15:32:40Z
dc.date.issued2012-10-01
dc.description.abstractBackground. Gastrointestinal (GI) complications are common after renal transplantation, mainly owing to immunosuppressive therapy. Assessment of GI transit time can facilitate rational management of these disorders.Objective. We evaluate the GI transit parameters in renal transplant recipients taking tacrolimus, azathioprine, and prednisone with the use of the alternate current biosusceptometry (ACB) technique and compared them with healthy volunteers.Methods. Ten renal transplant recipients and 10 healthy volunteers were enrolled in this study. After an overnight fast, patients and volunteers ingested a standard meal containing magnetic markers. The biomagnetic monitoring was performed at 10-minute intervals for at least 8 hours to obtain gastric emptying as well as the colonic arrival time-intensity curves. Mean gastric emptying time (MGET), mean colon arrival time (MCAT), and mean small intestinal transit time (MSITT) were quantified and compared between control and patient groups with results expressed as mean +/- SD.Results. The MGET measured by the ACB technique was 48 +/- 31 minutes and 197 +/- 50 minutes for patients and healthy subjects, respectively. MSITT and MCAT values calculated for patients versus volunteers were 171 +/- 71 minutes versus 197 +/- 71 minutes and 219 +/- 83 minutes versus 373 +/- 52 minutes, respectively. Renal transplant recipients showed significantly faster; gastric emptying and colon arrival times (P < .001) compared with normal volunteers; however, small intestinal transit time was not significantly different (P = .44).Conclusions. In stable renal transplant recipients, the GI transit parameters were significantly faster than in normal healthy volunteers. ACB sensors are versatile technologies that can be used for clinical research, because they offer an excellent opportunity to evaluate GI transit in a noninvasive manner without the use of ionizing radiation.en
dc.description.affiliationFAMED Univ Estadual Ciencias Saúde Alagoas UNCISA, Maceio, Brazil
dc.description.affiliationUTR Ctr Hosp Manoel Andre CHAMA, Arapiraca, Brazil
dc.description.affiliationIBB Univ Estadual Paulista UNESP, Botucatu, SP, Brazil
dc.description.affiliationFMRP Univ São Paulo USP, Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespIBB Univ Estadual Paulista UNESP, Botucatu, SP, Brazil
dc.format.extent2384-2387
dc.identifierhttp://dx.doi.org/10.1016/j.transproceed.2012.07.048
dc.identifier.citationTransplantation Proceedings. New York: Elsevier B.V., v. 44, n. 8, p. 2384-2387, 2012.
dc.identifier.doi10.1016/j.transproceed.2012.07.048
dc.identifier.issn0041-1345
dc.identifier.urihttp://hdl.handle.net/11449/41509
dc.identifier.wosWOS:000309736900033
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofTransplantation Proceedings
dc.relation.ispartofjcr0.806
dc.relation.ispartofsjr0,422
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleAssessment of Gastrointestinal Motility in Renal Transplant Recipients by Alternate Current Biosusceptometryen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-8306-8056[5]

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