Time between symptom and testing in relation to familial transmission of severe acute respiratory syndrome coronavirus 2

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dc.contributor.authorMenezes, Daiane Cabrera [UNESP]
dc.contributor.authorPerico, Jonatas [UNESP]
dc.contributor.authorMartins, Bruna Letícia [UNESP]
dc.contributor.authorBelone, Andrea de Faria Fernandes
dc.contributor.authorFortaleza, Carlos Magno Castelo Branco [UNESP]
dc.contributor.authorSantana, Fabiana Covolo de Souza
dc.contributor.authorLatini, Ana Carla Pereira [UNESP]
dc.contributor.authorde Souza, Vania Nieto Brito [UNESP]
dc.contributor.institutionSecretaria de Estado da Saúde
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:57:09Z
dc.date.available2023-07-29T13:57:09Z
dc.date.issued2023-01-01
dc.description.abstractBrazil has a huge number of cases and deaths due to coronavirus disease 2019 (COVID-19); however, few studies have dealt with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among familial contacts in Brazil. Here, we report our findings on transmission in a family-based study in Bauru, São Paulo, Brazil. The study, conducted from July to November 2020, comprised 974 individuals with 233 index patients and 741 familial contacts. Familial contacts were evaluated using the rapid COVID-19 Ag ECO and reverse transcription-polymerase chain reaction (RT-PCR) tests immediately after the index patient diagnosis. The antigen-based rapid test was validated in 121 individuals using RT-PCR as the gold standard. Additionally, 30 days later, familial contacts were evaluated for IgM and IgG antibodies against SARS-CoV-2. We found 333 cases of COVID-19 among familial contacts (44.9%). A positive correlation was observed between the time elapsed from the onset of symptoms until the index patient’s COVID-19 testing and the number of family contacts infected by SARS-CoV-2. Early SARSCoV-2 testing and familial contact evaluation are relevant strategies to contain transmission.en
dc.description.affiliationInstituto Lauro de Souza Lima Secretaria de Estado da Saúde, Rod. Cmte. João Ribeiro de Barros s/n, Distrito Industrial Marcus Vinícius Feliz Machado, SP
dc.description.affiliationPrograma de PósGraduação em Doenças Tropicais Faculdade de Medicina de Botucatu Universidade Estadual Paulista “Julio de Mesquita Filho” (Unesp), SP
dc.description.affiliationDepartamento de Infectologia Faculdade de Medicina de Botucatu Unesp, SP
dc.description.affiliationUnespPrograma de PósGraduação em Doenças Tropicais Faculdade de Medicina de Botucatu Universidade Estadual Paulista “Julio de Mesquita Filho” (Unesp), SP
dc.description.affiliationUnespDepartamento de Infectologia Faculdade de Medicina de Botucatu Unesp, SP
dc.format.extent1751-1756
dc.identifierhttp://dx.doi.org/10.1590/1413-81232023286.16112022
dc.identifier.citationCiencia e Saude Coletiva, v. 28, n. 6, p. 1751-1756, 2023.
dc.identifier.doi10.1590/1413-81232023286.16112022
dc.identifier.issn1678-4561
dc.identifier.issn1413-8123
dc.identifier.scopus2-s2.0-85160617116
dc.identifier.urihttp://hdl.handle.net/11449/248912
dc.language.isoeng
dc.relation.ispartofCiencia e Saude Coletiva
dc.sourceScopus
dc.subjectCOVID-19
dc.subjectPandemic
dc.subjectSARS-CoV-2
dc.titleTime between symptom and testing in relation to familial transmission of severe acute respiratory syndrome coronavirus 2en
dc.titleTempo entre o início dos sintomas e a testagem está relacionado à maior transmissão de SARS-CoV-2 entre contatos familiarespt
dc.typeArtigo
unesp.author.orcid0000-0003-0375-0977[1]
unesp.author.orcid0000-0001-9586-3885[2]
unesp.author.orcid0000-0001-9986-7699[3]
unesp.author.orcid0000-0001-5218-3863[4]
unesp.author.orcid0000-0003-4120-1258[5]
unesp.author.orcid0000-0001-7955-4310[6]
unesp.author.orcid0000-0002-5784-9959[7]
unesp.author.orcid0000-0002-4963-769X[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentDoenças Tropicais e Diagnósticos por Imagem - FMBpt

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Botucatu - FMB - Faculdade de Medicina