Involvement of the insular cortex in the consolidation and expression of contextual fear conditioning

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dc.contributor.authorAlves, Fernando H. F.
dc.contributor.authorGomes, Felipe V.
dc.contributor.authorReis, Daniel G.
dc.contributor.authorCrestani, Carlos Cesar [UNESP]
dc.contributor.authorCorrêa, Fernando M. A.
dc.contributor.authorGuimarães, Francisco S.
dc.contributor.authorResstel, Leonardo B. M.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:29:50Z
dc.date.available2014-05-27T11:29:50Z
dc.date.issued2013-07-01
dc.description.abstractThe insular cortex (IC) has been reported to be involved in the modulation of memory and autonomic and defensive responses. However, there is conflicting evidence about the role of the IC in fear conditioning. To explore the IC involvement in both behavioral and autonomic responses induced by contextual fear conditioning, we evaluated the effects of the reversible inhibition of the IC neurotransmission through bilateral microinjections of the non-selective synapse blocker CoCl2 (1 mm) 10 min before or immediately after the conditioning session or 10 min before re-exposure to the aversive context. In the conditioning session, rats were exposed to a footshock chamber (context) and footshocks were used as the unconditioned stimulus. Forty-eight hours later, the animals were re-exposed to the aversive context for 10 min, but no shock was given. Behavioral (freezing) as well as cardiovascular (arterial pressure and heart rate increases) responses induced by re-exposure to the aversive context were analysed. It was observed that the local IC neurotransmission inhibition attenuated freezing and the mean arterial pressure and heart rate increase of the groups that received the CoCl2 either immediately after conditioning or 10 min before re-exposure to the aversive context, but not when the CoCl2 was injected before the conditioning session. These findings suggest the involvement of the IC in the consolidation and expression of contextual aversive memory. However, the IC does not seem to be essential for the acquisition of memory associated with aversive context. © 2013 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.en
dc.description.affiliationDepartment of Pharmacology School of Medicine of Ribeirão Preto University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, São Paulo, 14049-900
dc.description.affiliationCenter for Interdisciplinary Research on Applied Neurosciences (NAPNA) University of São Paulo, São Paulo, São Paulo
dc.description.affiliationDepartment of Natural Active Principles and Toxicology School of Pharmaceutical Sciences São Paulo State University - UNESP, Araraquara, São Paulo
dc.description.affiliationUnespDepartment of Natural Active Principles and Toxicology School of Pharmaceutical Sciences São Paulo State University - UNESP, Araraquara, São Paulo
dc.format.extent2300-2307
dc.identifierhttp://dx.doi.org/10.1111/ejn.12210
dc.identifier.citationEuropean Journal of Neuroscience, v. 38, n. 2, p. 2300-2307, 2013.
dc.identifier.doi10.1111/ejn.12210
dc.identifier.issn0953-816X
dc.identifier.issn1460-9568
dc.identifier.lattes1117432571971568
dc.identifier.scopus2-s2.0-84880326143
dc.identifier.scopus2-s2.0-84876145116
dc.identifier.urihttp://hdl.handle.net/11449/75809
dc.identifier.wosWOS:000321704800011
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Neuroscience
dc.relation.ispartofjcr2.832
dc.relation.ispartofsjr1,757
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAutonomic system
dc.subjectBlood pressure
dc.subjectFreezing
dc.subjectHeart rate
dc.subjectPrefrontal cortex
dc.subjectRat
dc.subjectanimal behavior
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectarterial pressure
dc.subjectcardiovascular response
dc.subjectconditioning
dc.subjectcontextual fear conditioning
dc.subjectcontrolled study
dc.subjectdiscrimination learning
dc.subjectfear
dc.subjectfootshock
dc.subjectfunctional anatomy
dc.subjectheart rate
dc.subjectinsula
dc.subjectmale
dc.subjectmemory consolidation
dc.subjectneuroanatomy
dc.subjectnonhuman
dc.subjectpresynaptic inhibition
dc.subjectpriority journal
dc.subjectrat
dc.subjectresponse time
dc.subjectstimulus response
dc.titleInvolvement of the insular cortex in the consolidation and expression of contextual fear conditioningen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
unesp.author.lattes1117432571971568[4]
unesp.author.orcid0000-0002-1942-858X[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentPrincípios Ativos Naturais e Toxicologia - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas