Doxycycline and Autogenous Bone in Repair of Critical-Size Defects

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dc.contributor.authorLucateli, Ribamar Lazanha
dc.contributor.authorMarciano, Marina Angelica
dc.contributor.authorFerreira, Sabrina [UNESP]
dc.contributor.authorGarcia Junior, Idelmo Rangel [UNESP]
dc.contributor.authorCamilleri, Josette
dc.contributor.authorMariano, Ronaldo Celio
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Malta UM
dc.contributor.institutionFed Univ Alfenas UNIFAL
dc.date.accessioned2018-11-26T17:54:46Z
dc.date.available2018-11-26T17:54:46Z
dc.date.issued2018-08-01
dc.description.abstractPurpose: The association of doxycycline (DOX) and autogenous bone on repair of critical-size defects was evaluated. Materials and Methods: Fifty albino rats were divided into 5 groups (n = 10). A 5-mm diameter defect was treated with: control (CO)-blood clot; DOX in Natrosol (NAT)-10% gel; NAT-gel; particulate autogenous bone (PAB); and PAB + DOX - PAB associated with 10% DOX gel. The animals were euthanized at 4 and 8 weeks postoperatively. Histomorphometric analysis was performed to assess the percentage of new bone in the defect area. Statistical analysis of the results was performed using analysis of variance and the Tukey test (P < 0.05). Results: The results showed that new bone formation was limited to the margins of the defect. At 4 and 8 weeks, the group PAB + DOX showed higher bone formation (38.59% and 47.86%, respectively), with statistical difference in comparison with the CO (19.52%) at 4 weeks and CO (18.80%), DOX (22.05%), and NAT (15.89%) at 8 weeks (P < 0.05). Conclusions: The association of 10% DOX with autogenous bone significantly improved bone healing in critical-size defects.en
dc.description.affiliationUniv Sao Paulo, Ribeirao Preto Sch Dent, Dept Surg & Periodontol, Sao Paulo, Brazil
dc.description.affiliationState Univ Campinas UNICAMP, Piracicaba Sch Dent, Dept Restorat Dent, Sao Paulo, Brazil
dc.description.affiliationUniv State Sao Paulo UNESP, Aracatuba Sch Dent, Dept Integrated Clin & Surg, Sao Paulo, Brazil
dc.description.affiliationUniv Malta UM, Fac Dent Surg, Dept Operat Dent, Msida, Malta
dc.description.affiliationFed Univ Alfenas UNIFAL, Dept Surg, Alfenas Sch Dent, Alfenas, MG, Brazil
dc.description.affiliationUnespUniv State Sao Paulo UNESP, Aracatuba Sch Dent, Dept Integrated Clin & Surg, Sao Paulo, Brazil
dc.description.sponsorshipState of Sao Paulo University (UNESP - Aracatuba)
dc.format.extent461-466
dc.identifierhttp://dx.doi.org/10.1097/ID.0000000000000783
dc.identifier.citationImplant Dentistry. Philadelphia: Lippincott Williams & Wilkins, v. 27, n. 4, p. 461-466, 2018.
dc.identifier.doi10.1097/ID.0000000000000783
dc.identifier.issn1056-6163
dc.identifier.urihttp://hdl.handle.net/11449/164493
dc.identifier.wosWOS:000440895700010
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofImplant Dentistry
dc.relation.ispartofsjr0,712
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbone regeneration
dc.subjectbone graft
dc.subjectosseous defects
dc.titleDoxycycline and Autogenous Bone in Repair of Critical-Size Defectsen
dc.typeArtigo
dcterms.rightsHolderLippincott Williams & Wilkins

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Artigos - Cirurgia e Clínica Integrada - FOA