Research of new mixed-chelate copper complexes with quinoxaline N 1,N 4,-dioxide derivatives and alanine as ligands, potential antimycobacterial agents

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dc.contributor.authorBelén Tarallo, M.
dc.contributor.authorCosta-Filho, A. J.
dc.contributor.authorVieira, Ernanni D.
dc.contributor.authorMonge, Antonio
dc.contributor.authorLeite, Clarice Q. [UNESP]
dc.contributor.authorPavan, Fernando Rogério [UNESP]
dc.contributor.authorBorthagaray, Graciela
dc.contributor.authorGambino, Dinorah
dc.contributor.authorTorre, María H.
dc.contributor.institutionCátedra de Química Inorgánica
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidad de Navarra
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidad de la República, Gral
dc.date.accessioned2014-05-27T11:23:51Z
dc.date.available2014-05-27T11:23:51Z
dc.date.issued2009-01-01
dc.description.abstractThree new mixed-chelate copper complexes with 3-aminoquinoxaline-2-carbonitrile N 1,N 4-dioxide derivatives and alanine as ligands were synthesized in solid state. The spectroscopic characterization (FTIR, EPR, UV-Vis) showed that copper coordinated through the amine and the N-oxide groups of the quinoxaline derivatives and the amine and carboxylate moieties from alanine forming a dimeric species. The tree complexes showed in vitro activity against M. tuberculosis H 37Rv (ATCC 27294) similar to that of ethambutol while they are inactive against E. coli and S. aureus.en
dc.description.affiliationCátedra de Química Inorgánica, Gral Flores 2124, C. C. 1157, 11800 Montevideo
dc.description.affiliationInstituto de Física de São Carlos Universidade de São Paulo, C.P. 369, 13560, São Carlos
dc.description.affiliationCIFA Universidad de Navarra, Pamplona, España
dc.description.affiliationFaculdade de Ciencias Farmacêuticas Unesp, C.P. 582, 14801-902-Araquara(SP)
dc.description.affiliationCátedra de Microbiología Facultad de Química Universidad de la República, Gral, Flores 2124, C. C. 1157, 11800 Montevideo
dc.description.affiliationUnespFaculdade de Ciencias Farmacêuticas Unesp, C.P. 582, 14801-902-Araquara(SP)
dc.format.extent80-89
dc.identifierhttp://www.aqa.org.ar/pdf9701/9701art8.pdf
dc.identifier.citationJournal of the Argentine Chemical Society, v. 97, n. 1, p. 80-89, 2009.
dc.identifier.issn0365-0375
dc.identifier.scopus2-s2.0-79959608363
dc.identifier.urihttp://hdl.handle.net/11449/70908
dc.language.isoeng
dc.relation.ispartofJournal of the Argentine Chemical Society
dc.relation.ispartofsjr0,123
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAntimycobacterial agents
dc.subjectCopper complexes
dc.subjectQuinoxaline derivatives
dc.titleResearch of new mixed-chelate copper complexes with quinoxaline N 1,N 4,-dioxide derivatives and alanine as ligands, potential antimycobacterial agentsen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt

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