Antimutagenic effect of Agaricus blazei Murrill mushroom on the genotoxicity induced by cyclophosphamide

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dc.contributor.authorDelmanto, R. D.
dc.contributor.authorde Lima, PLA
dc.contributor.authorSugui, M. M.
dc.contributor.authorda Eira, A. F.
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.authorSpeit, G.
dc.contributor.authorRibeiro, L. R.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Ulm Klinikum
dc.date.accessioned2014-05-20T13:37:03Z
dc.date.available2014-05-20T13:37:03Z
dc.date.issued2001-09-20
dc.description.abstractAgaricus blazei Murrill extracts have previously been shown to have anticarcinogenic and antimutagenic proper-ties. These results suggest that antimutagenic activity, besides the modulation of the immune system, might be involved in the anticarcinogenic action of A. blazei. To investigate the possible antimutagenic effect of A. blazei in vivo, we evaluated its effect on clastogenicity induced by cyclophosphamide (CP) in mice, using the micronucleus test in bone marrow (MNPCE) and in peripheral blood (MNRET). Male Swiss mice were treated with CP (25 or 50 mg/kg i.p.) or with CP plus mushroom solution at three different temperatures: 4, 21, and 60 degreesC. Aqueous solution of a mixture from various lineages of the mushroom inhibited induction of micronuclei by CP in bone marrow and in peripheral blood of mice. In contrast to the mixture of lineages, a single isolated lineage did not lead to a reduction of CP-induced MN frequencies in either bone marrow or blood cells of mice. The results suggest that under certain circumstances these mushrooms exhibit antimutagenic activities that might contribute to an anticarcinogenic effect. (C) 2001 Elsevier B.V. B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Med, Dept Patol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Ciências Agron, Dept Prod Vegetal Modulo Cogumelos, BR-18603970 Botucatu, SP, Brazil
dc.description.affiliationUniv Ulm Klinikum, Abt Humangenet, Ulm, Germany
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Med, Dept Patol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Ciências Agron, Dept Prod Vegetal Modulo Cogumelos, BR-18603970 Botucatu, SP, Brazil
dc.format.extent15-21
dc.identifierhttp://dx.doi.org/10.1016/S1383-5718(01)00228-5
dc.identifier.citationMutation Research-genetic Toxicology and Environmental Mutagenesis. Amsterdam: Elsevier B.V., v. 496, n. 1-2, p. 15-21, 2001.
dc.identifier.doi10.1016/S1383-5718(01)00228-5
dc.identifier.issn1383-5718
dc.identifier.lattes5051118752980903
dc.identifier.urihttp://hdl.handle.net/11449/12781
dc.identifier.wosWOS:000170481900003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMutation Research: Genetic Toxicology and Environmental Mutagenesis
dc.relation.ispartofjcr1.996
dc.relation.ispartofsjr0,747
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectantimutagenicitypt
dc.subjectAgaricus blazei Murrillpt
dc.subjectmicronucleus testpt
dc.subjectcyclophosphamidept
dc.titleAntimutagenic effect of Agaricus blazei Murrill mushroom on the genotoxicity induced by cyclophosphamideen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0001-9323-3134[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agronômicas, Botucatupt
unesp.departmentProdução e Melhoramento Vegetal - FCApt

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Botucatu - FCA - Faculdade de Ciências Agronômicas