Biology of bone tissue: structure, function, and factors that influence bone cells

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dc.contributor.authorFlorencio-Silva, Rinaldo
dc.contributor.authorSasso, Gisela Rodrigues da Silva
dc.contributor.authorSasso-Cerri, Estela [UNESP]
dc.contributor.authorSimões, Manuel Jesus
dc.contributor.authorCerri, Paulo Sérgio [UNESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:32:34Z
dc.date.available2015-12-07T15:32:34Z
dc.date.issued2015
dc.description.abstractBone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process. This process is under the control of local (e.g., growth factors and cytokines) and systemic (e.g., calcitonin and estrogens) factors that all together contribute for bone homeostasis. An imbalance between bone resorption and formation can result in bone diseases including osteoporosis. Recently, it has been recognized that, during bone remodeling, there are an intricate communication among bone cells. For instance, the coupling from bone resorption to bone formation is achieved by interaction between osteoclasts and osteoblasts. Moreover, osteocytes produce factors that influence osteoblast and osteoclast activities, whereas osteocyte apoptosis is followed by osteoclastic bone resorption. The increasing knowledge about the structure and functions of bone cells contributed to a better understanding of bone biology. It has been suggested that there is a complex communication between bone cells and other organs, indicating the dynamic nature of bone tissue. In this review, we discuss the current data about the structure and functions of bone cells and the factors that influence bone remodeling.en
dc.description.affiliationDepartamento de Morfologia e Genética, Laboratório de Histologia e Biologia Estrutural, Universidade Federal de São Paulo, 04023-900 São Paulo, SP, Brasil
dc.description.affiliationDepartamento de Morfologia, Laboratório de Histologia e Embriologia, Faculdade de Odontologia, Universidade Estadual Paulista (UNESP), 14801-903 Araraquara, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Morfologia, Faculdade de Odontologia de Araraquara
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2010/10391-9
dc.description.sponsorshipIdFAPESP: 2012/19428-8
dc.description.sponsorshipIdFAPESP: 2012/22666-8
dc.format.extent1-18
dc.identifierhttp://dx.doi.org/10.1155/2015/421746
dc.identifier.citationBioMed Research International, v. 2015, p. 1-18, 2015.
dc.identifier.doi10.1155/2015/421746
dc.identifier.filePMC4515490.pdf
dc.identifier.issn2314-6141
dc.identifier.lattes4455630076841302
dc.identifier.lattes3278495911207882
dc.identifier.lattes3278495911207882
dc.identifier.orcid0000-0001-5756-5828
dc.identifier.pmcPMC4515490
dc.identifier.pubmed26247020
dc.identifier.urihttp://hdl.handle.net/11449/131203
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofBioMed Research International
dc.relation.ispartofsjr0,935
dc.rights.accessRightsAcesso aberto
dc.sourcePubMed
dc.titleBiology of bone tissue: structure, function, and factors that influence bone cellsen
dc.typeArtigo
dcterms.rightsHolderHindawi Publishing Corporation
unesp.author.lattes4455630076841302
unesp.author.lattes3278495911207882
unesp.author.lattes3278495911207882[5]
unesp.author.orcid0000-0001-5756-5828[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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