Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in rats

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dc.contributor.authorVieira, Jonas O. [UNESP]
dc.contributor.authorDuarte, Josiane O. [UNESP]
dc.contributor.authorCosta-Ferreira, Willian [UNESP]
dc.contributor.authorMorais-Silva, Gessynger [UNESP]
dc.contributor.authorMarin, Marcelo T. [UNESP]
dc.contributor.authorCrestani, Carlos C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:48:58Z
dc.date.available2018-12-11T16:48:58Z
dc.date.issued2018-02-02
dc.description.abstractThis study investigated the physiological, somatic and behavioral changes evoked by daily exposure to the same type of stressor (homotypic) or different aversive stressor stimuli (heterotypic) in male and female rats. For this, adult Wistar rats were subjected to a 10 days regimen of repeated restraint stress (RRS, homotypic stressor) or chronic variable stress (CVS, heterotypic stressor). Effects evoked by CVS included: (i) adrenal hypertrophy and decreased body weight gain in male animals, (ii) a sympathetically-mediated increase in basal heart rate in males, and (iii) a rise in plasma corticosterone concentration and anxiogenic effects in female animals. The homotypic stressor RRS also induced an increase in plasma corticosterone and anxiogenic effects in females, decreased body weight gain in males and evoked a sympathetically-mediated increase in heart rate in both sexes. Changes in cardiovascular function and autonomic activity evoked by both stressors were followed by impairment of baroreflex activity in males, but not female animals. Both chronic stressors evoked changes in blood pressure responsiveness to vasoconstrictor and vasodilator agents in both sexes. Taken together, these results indicate that regardless of chronic stress regimen males are more vulnerable to somatic effects of chronic stressors, while females appear to be more susceptible to neuroendocrine and behavioral changes. Present findings also indicate that females are selectively vulnerable to cardiovascular and autonomic changes evoked by homotypic stressors. Nevertheless, homotypic and heterotypic stressors similarly affect cardiovascular function and autonomic activity in males.en
dc.description.affiliationLaboratory of Pharmacology São Paulo State University (UNESP) School of Pharmaceutical Sciences
dc.description.affiliationJoint UFSCar-UNESP Graduate Program in Physiological Sciences
dc.description.affiliationUnespLaboratory of Pharmacology São Paulo State University (UNESP) School of Pharmaceutical Sciences
dc.description.affiliationUnespJoint UFSCar-UNESP Graduate Program in Physiological Sciences
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2012/14376-0
dc.description.sponsorshipIdFAPESP: 2015/05922-9
dc.description.sponsorshipIdCNPq: 305583/2015-8
dc.description.sponsorshipIdCNPq: 456405/2014-3
dc.format.extent426-437
dc.identifierhttp://dx.doi.org/10.1016/j.pnpbp.2017.08.014
dc.identifier.citationProgress in Neuro-Psychopharmacology and Biological Psychiatry, v. 81, p. 426-437.
dc.identifier.doi10.1016/j.pnpbp.2017.08.014
dc.identifier.file2-s2.0-85028337295.pdf
dc.identifier.issn1878-4216
dc.identifier.issn0278-5846
dc.identifier.scopus2-s2.0-85028337295
dc.identifier.urihttp://hdl.handle.net/11449/170064
dc.language.isoeng
dc.relation.ispartofProgress in Neuro-Psychopharmacology and Biological Psychiatry
dc.relation.ispartofsjr1,714
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAutonomic activity
dc.subjectBaroreflex
dc.subjectHPA axis
dc.subjectRestraint stress
dc.subjectUnpredictable stress
dc.subjectVascular
dc.titleSex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in ratsen
dc.typeArtigo
unesp.author.lattes1117432571971568[6]
unesp.author.orcid0000-0002-1942-858X[6]

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