Effects of Chamomilla recutita (L.) on oral wound healing in rats

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dc.contributor.authorDuarte, Carina-Magalhaes-Esteves
dc.contributor.authorQuirino, Maria-Rozelide-Souza
dc.contributor.authorPatrocinio, Monica-Cesar
dc.contributor.authorAnbinder, Ana-Lia [UNESP]
dc.contributor.institutionUniv Taubate
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:04:30Z
dc.date.available2014-05-20T14:04:30Z
dc.date.issued2011-09-01
dc.description.abstractObjectives. The purpose of this study was to evaluate the effect of Chamomilla recutita on the healing of ulcers in rats.Study Design. A 5-mm wound was inflicted on the tongue of 36 rats. Treatment group animals were treated topically with 0.04 mL/day of chamomile ointment, whereas control group animals were not treated. Animals were sacrificed after 3, 7 or 10 days. Semi-quantitative analysis of the degree of inflammation, fibroblast count and wound size was performed, as well as histometric analysis of re-epithelialization and percentage of collagen fibers of the lesion.Results. Animals treated with chamomile showed the best results regarding epithelialization and percentage of collagen fibers after 10 days. As expected, time had a statistically significant effect (p<0.05) on fibroblast count, epithelialization, inflammation and wound size; animals sacrificed at 3 days showed the worst results.Conclusions. Chamomile stimulated re-epithelialization and the formation of collagen fibers after 10 days of treatment; it did not, however, influence inflammation or fibroblast count.en
dc.description.affiliationUniv Taubate, Dept Dent, Taubate, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Sch Dent Sao Jose dos Campos, Dept Biosci & Oral Diag, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Sch Dent Sao Jose dos Campos, Dept Biosci & Oral Diag, Sao Jose Dos Campos, SP, Brazil
dc.format.extentE716-E721
dc.identifierhttp://dx.doi.org/10.4317/medoral.17029
dc.identifier.citationMedicina Oral Patologia Oral Y Cirugia Bucal. Valencia: Medicina Oral S L, v. 16, n. 6, p. E716-E721, 2011.
dc.identifier.doi10.4317/medoral.17029
dc.identifier.issn1698-4447
dc.identifier.orcid0000-0003-3930-4274
dc.identifier.urihttp://hdl.handle.net/11449/22633
dc.identifier.wosWOS:000298086400005
dc.language.isoeng
dc.publisherMedicina Oral S L
dc.relation.ispartofMedicina Oral Patologia Oral y Cirugia Bucal
dc.relation.ispartofsjr0,841
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectChamomileen
dc.subjectwound repairen
dc.subjectoral ulceren
dc.titleEffects of Chamomilla recutita (L.) on oral wound healing in ratsen
dc.typeArtigo
dcterms.licensehttp://scielo.isciii.es/revistas/medicor/eaboutj.htm
dcterms.rightsHolderMedicina Oral S L
unesp.author.lattes6097967943008273[4]
unesp.author.orcid0000-0003-3930-4274[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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Artigos - Biociências e Diagnóstico Bucal - ICT