Biochemical and histopathological responses in peripubertal male rats exposed to agrochemicals isolated or in combination: A multivariate data analysis study

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dc.contributor.authorAranha, Maria Luiza Garcia
dc.contributor.authorGarcia, Mariana Simões
dc.contributor.authorde Carvalho Cavalcante, Deborah Navit
dc.contributor.authorSilva, Ana Priscila Gomes
dc.contributor.authorFontes, Mayana Karoline [UNESP]
dc.contributor.authorGusso-Choueri, Paloma Kachel [UNESP]
dc.contributor.authorChoueri, Rodrigo Brasil
dc.contributor.authorPerobelli, Juliana Elaine
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-06-25T10:46:14Z
dc.date.available2021-06-25T10:46:14Z
dc.date.issued2021-01-15
dc.description.abstractThe widespread use of agrochemicals results in the exposure of the general human population, including children, to several of these chemicals simultaneously. In the present preclinical study, it was investigated the hepatic damages caused by exposure to acephate, carbendazim and mancozeb when administered alone or in different combinations (binary and ternary). Juvenile male Wistar rats were exposed to agrochemicals from post-natal day 53, by gavage. The doses of agrochemicals applied here were determined from previous studies whose results showed no signs of systemic toxicity. All exposures provoked a significant increase in DNA damage (except for acephate alone) and activation of the xenobiotic biotransformation system (except for the ternary mixture). Interestingly, the ternary mixture did not exhibit an exacerbation in adverse effects caused by agrochemicals isolated or in binary combination, even though they are sharing genotoxicity damage induction as a common toxicity pathway. Conversely, some effects observed for isolated or binary combinations of agrochemicals were not observed for ternary combination, suggesting a chemical interaction that could imply antagonism character. Using a multivariate data analysis approach, exposure to isolated agrochemicals were related to a group of adverse effects characterized by hepatic lesion and the attempt of the tissue to mobilize defense cells and increase mitotic rates to minimize damages. Binary mixtures also share similarities in relation to the effects they exhibited, mainly a moderate to high increase in the GST activity and in histopathological alterations suggesting that binary combinations trigger an increased response of the mechanism of xenobiotics biotransformation. Together, obtained results bring important insights regarding adverse effects and possible interaction of the three agrochemicals whose residues are commonly detected in agro-food products.en
dc.description.affiliationExperimental Toxicology Laboratory Departamento de Ciências do Mar Universidade Federal de São Paulo – UNIFESP
dc.description.affiliationNúcleo de Estudos em Poluição e Ecotoxicologia Aquática Campus do Litoral Paulista Universidade Estadual Paulista – UNESP
dc.description.affiliationDepartamento de Ciências do Mar Universidade Federal de São Paulo – UNIFESP
dc.description.affiliationUnespNúcleo de Estudos em Poluição e Ecotoxicologia Aquática Campus do Litoral Paulista Universidade Estadual Paulista – UNESP
dc.identifierhttp://dx.doi.org/10.1016/j.tox.2020.152636
dc.identifier.citationToxicology, v. 447.
dc.identifier.doi10.1016/j.tox.2020.152636
dc.identifier.issn1879-3185
dc.identifier.issn0300-483X
dc.identifier.scopus2-s2.0-85097217244
dc.identifier.urihttp://hdl.handle.net/11449/206932
dc.language.isoeng
dc.relation.ispartofToxicology
dc.sourceScopus
dc.subjectBiochemical biomarkers
dc.subjectHistopathology
dc.subjectMixtures
dc.subjectOxidative stress
dc.subjectPesticides
dc.titleBiochemical and histopathological responses in peripubertal male rats exposed to agrochemicals isolated or in combination: A multivariate data analysis studyen
dc.typeArtigo
unesp.author.orcid0000-0001-6608-2502[1]
unesp.author.orcid0000-0001-6500-7930[2]

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