Ovariectomy increases the phenotypic plasticity of the female prostate epithelium in the Mongolian gerbil (Meriones unguiculatus)

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dc.contributor.authorZanatelli, Marianna
dc.contributor.authorCustodio, Ana M. G.
dc.contributor.authorBiancardi, Manoel F.
dc.contributor.authorSantos, Fernanda C. A.
dc.contributor.authorGóes, Rejane M. [UNESP]
dc.contributor.authorFalleiros-Jr, Luiz R. [UNESP]
dc.contributor.authorVilamaior, Patricia S. L. [UNESP]
dc.contributor.authorTaboga, Sebastião R. [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:14:00Z
dc.date.available2018-12-11T17:14:00Z
dc.date.issued2017-01-01
dc.description.abstractThe female prostate is a reproductive gland that typically presents a morphology similar to that of the male gland and is highly developed in female Mongolian gerbils. Two main cell populations compose the epithelium gland: basal and secretory luminal cells. However, during postnatal development, diverse secretory cell phenotypes are distributed among the typical ones. Prostate homeostasis is under the control of sexual hormones, such as oestrogen and progesterone. After hormonal deprivation the female gland undergoes several morphophysiological changes. The objective of this study was to identify and characterise, structurally and ultrastructurally, the cellular heterogeneity of the female prostate epithelium in normal conditions and after ovariectomy. Histological routine stains, such as haematoxylin-eosin, periodic acid-Schiff and silver impregnation, as well as immunocytochemical techniques were used to enable identification of the different cell types. Some secretory cells types were identified and characterised as mucinous, basophil, clear, ciliated, droplet, spumous and neuroendocrine cells. Population tally data showed that the hormonal suppression caused by ovariectomy resulted in a decrease in the proportions of basophil and clear cells and an increase in spumous cells. Thus, the secretory epithelial cells of the female gerbil prostate are not morphologically and functionally uniform, presenting a phenotypical plasticity according to the hormonal environment in which they operate.en
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biology State University of Campinas UNICAMP
dc.description.affiliationDepartment of Morphology Federal University of Goiás UFG
dc.description.affiliationLaboratory of Microscopy and Microanalysis Department of Biology São Paulo State University UNESP/IBILCE, R Cristovão Colombo, 2265
dc.description.affiliationUnespLaboratory of Microscopy and Microanalysis Department of Biology São Paulo State University UNESP/IBILCE, R Cristovão Colombo, 2265
dc.format.extent1751-1762
dc.identifierhttp://dx.doi.org/10.1071/RD16037
dc.identifier.citationReproduction, Fertility and Development, v. 29, n. 9, p. 1751-1762, 2017.
dc.identifier.doi10.1071/RD16037
dc.identifier.issn1448-5990
dc.identifier.issn1031-3613
dc.identifier.lattes7066358123790434
dc.identifier.orcid0000-0001-9559-5497
dc.identifier.scopus2-s2.0-85027512705
dc.identifier.urihttp://hdl.handle.net/11449/175049
dc.language.isoeng
dc.relation.ispartofReproduction, Fertility and Development
dc.relation.ispartofsjr0,681
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectcell types
dc.subjectelectron microscopy
dc.subjecthormonal deprivation
dc.subjectimmunocytochemistry
dc.subjectsecretory cells.
dc.titleOvariectomy increases the phenotypic plasticity of the female prostate epithelium in the Mongolian gerbil (Meriones unguiculatus)en
dc.typeArtigo
unesp.author.lattes7066358123790434[7]
unesp.author.orcid0000-0001-9559-5497[7]

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