The Ultrastructural Study of Tumorigenic Cells Using Nanobiomarkers

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dc.contributor.authorPavon, Lorena Favaro
dc.contributor.authorMarti, Luciana Cavalheiro
dc.contributor.authorSibov, Tatiana Tais
dc.contributor.authorMalheiros, Suzana M. F.
dc.contributor.authorOliveira, Daniela Mara
dc.contributor.authorGuilhen, Daiane Donna
dc.contributor.authorCamargo-Mathias, Maria Izabel [UNESP]
dc.contributor.authorAmaro Junior, Edson
dc.contributor.authorGamarra, Lionel Fernel
dc.contributor.institutionSBIBHAE
dc.contributor.institutionIIEPAE
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de São João del-Rei (UFSJ)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:55:49Z
dc.date.available2014-05-20T13:55:49Z
dc.date.issued2010-06-01
dc.description.abstractDespite recent advances, patients with malignant brain tumors still have a poor prognosis. Glioblastoma (WHO grade 4 astrocytoma), the most malignant brain tumor, represents 50% of all astrocytomas, with a median survival rate of <1 year. It is, therefore, extremely important to search for new diagnostic and therapeutic approaches for patients with glioblastoma. This study describes the application of superparamagnetic nano-particles of iron oxide, as well as monoclonal antibodies, of immunophenotypic significance, conjoined to quantum dots for the ultrastructural assessment of glioblastoma cells. For this proposal, an immunophenotypic study by flow cytometry was carried out, followed by transmission electron microscopy analysis. The process of tumor cell labeling using nanoparticles can successfully contribute to the identification of tumorigenic cells and consequently for better understanding of glioblastoma genesis and recurrence. In addition, this method may help further studies in tumor imaging, diagnosis, and prognostic markers detection.en
dc.description.affiliationSBIBHAE, INCE, IIEPAE, BR-05651901 São Paulo, Brazil
dc.description.affiliationIIEPAE, Ctr Pesquisa Expt, São Paulo, Brazil
dc.description.affiliationUniv Fed São Paulo, Dept Neurol & Neurochirurg, São Paulo, Brazil
dc.description.affiliationUniv Fed Sao Joao Del Rei, Sao Joao Del Rei, Brazil
dc.description.affiliationUNESP, Dept Biol, Inst Biociencias, Rio Claro, Brazil
dc.description.affiliationUniv São Paulo, Dept Radiol, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Dept Biol, Inst Biociencias, Rio Claro, Brazil
dc.description.sponsorshipInstituto Israelita de Ensino e Pesquisa Albert Einstein
dc.description.sponsorshipSociedade Beneficente Israelita Brasileira Hospital Albert Einstein (SBIBHAE)
dc.description.sponsorshipIdInstituto Israelita de Ensino e Pesquisa Albert Einstein: IIEP/278-07
dc.format.extent289-298
dc.identifierhttp://dx.doi.org/10.1089/cbr.2009.0697
dc.identifier.citationCancer Biotherapy and Radiopharmaceuticals. New Rochelle: Mary Ann Liebert Inc., v. 25, n. 3, p. 289-298, 2010.
dc.identifier.doi10.1089/cbr.2009.0697
dc.identifier.fileWOS000279177300005.pdf
dc.identifier.issn1084-9785
dc.identifier.urihttp://hdl.handle.net/11449/19996
dc.identifier.wosWOS:000279177300005
dc.language.isoeng
dc.publisherMary Ann Liebert, Inc.
dc.relation.ispartofCancer Biotherapy and Radiopharmaceuticals
dc.relation.ispartofjcr1.682
dc.relation.ispartofsjr0,567
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcancer diagnosisen
dc.subjectglioblastomaen
dc.subjectimmunolocalizationen
dc.subjectmarkersen
dc.subjectnanoparticlesen
dc.subjectultrastructuralen
dc.titleThe Ultrastructural Study of Tumorigenic Cells Using Nanobiomarkersen
dc.typeArtigo
dcterms.licensehttp://www.liebertpub.com/openaccess/cancer-biotherapy-and-radiopharmaceuticals/8/
dcterms.rightsHolderMary Ann Liebert Inc.
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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Artigos - Biologia - IBRC