Antineoplastic properties and pharmacological applications of Crotalus durissus terrificus snake venom

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dc.contributor.authorAlves, Brunna Fernanda Arraez
dc.contributor.authorFerreira, Rui Seabra [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:33:49Z
dc.date.available2023-07-29T13:33:49Z
dc.date.issued2022-01-01
dc.description.abstractSnake toxins are widely studied owing to their importance in snakebite accidents, a serious public health issue in tropical countries, and their broad therapeutic potential. Isolated fractions from venom produced by snakes of the genus Crotalus sp. present a wide variety of pharmacological uses such as antifungal, antiviral, antibacterial, and antitumor properties, among other therapeutic potentialities. Given the direct effect of this venom on tumor cells, isolation of its compounds is important for the characterization of its anticarcinogenic actions. Crotalus durissus terrificus venom and its toxins have been widely evaluated as potential candidates for the development of new antineoplastic therapies that are efficient against different tumor lines and cellular targets. This review highlights the venom toxins of this species, with a focus on their antineoplastic properties.en
dc.description.affiliationFaculty of Animal Science and Food Engineering University of São Paulo, SP
dc.description.affiliationCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (UNESP), SP
dc.description.affiliationUnespCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (UNESP), SP
dc.identifierhttp://dx.doi.org/10.1590/0037-8682-0323-2022
dc.identifier.citationRevista da Sociedade Brasileira de Medicina Tropical, v. 55.
dc.identifier.doi10.1590/0037-8682-0323-2022
dc.identifier.issn0037-8682
dc.identifier.scopus2-s2.0-85144598448
dc.identifier.urihttp://hdl.handle.net/11449/248075
dc.language.isoeng
dc.relation.ispartofRevista da Sociedade Brasileira de Medicina Tropical
dc.sourceScopus
dc.subjectAntitumor
dc.subjectCancer
dc.subjectCrotalid Venoms
dc.subjectCrotalus
dc.subjectSnake Venom
dc.titleAntineoplastic properties and pharmacological applications of Crotalus durissus terrificus snake venomen
dc.typeResenha

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Botucatu - CEVAP - Centro de Estudos de Venenos e Animais Peçonhentos