Evaluating the acute contributions of dopaminergic replacement to gait with obstacles in parkinson's disease

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dc.contributor.authorPieruccini-Faria, F.
dc.contributor.authorVitório, R.
dc.contributor.authorAlmeida, Q. J.
dc.contributor.authorSilveira, C. R.A.
dc.contributor.authorCaetano, M. J.D.
dc.contributor.authorStella, F.
dc.contributor.authorGobbi, S.
dc.contributor.authorGobbi, L. T.B.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionWilfrid Laurier University
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversity of Waterloo
dc.date.accessioned2022-04-28T18:58:52Z
dc.date.available2022-04-28T18:58:52Z
dc.date.issued2013-11-25
dc.description.abstractThe influence of dopaminergic replacement (DR) on gait in people with Parkinson's disease (PD) is well documented. However, little is known about the acute effects of dopamine on more complex locomotor tasks that require visual guidance to avoid obstacles during gait. The authors investigated the influence of DR on locomotor behavior in a task where movement planning and control might be challenged by the height of the obstacle. The PD group included patients diagnosed with idiopathic PD (n = 12), as well as healthy controls (n = 12). Patients walked and stepped over obstacles of different heights before (OFF) and after (ON) levodopa intake. Spatial adjustments were not modulated by DR, but the step time to perform these anticipatory gait adjustments was longer only in PD-OFF (compared with healthy controls) when approaching the highest obstacle, but not PD-ON. During the crossing phase, trail limb toe clearance of PD patients was shorter than healthy controls only during the OFF state. ON-OFF comparisons were significantly different only for the time to reach the lead foot clearance over the highest obstacle. In summary, DR partially improved movement slowness but did not directly affect movement amplitude of lower limb regulation in this gait task. Copyright © 2013 Taylor & Francis Group.en
dc.description.affiliationPhysical Education Department Posture and Gait Studies Lab University of Sao Paulo State
dc.description.affiliationSun Life Financial Movement Disorders Research and Rehabilitation Centre Wilfrid Laurier University, 66 Hickory Street West, Waterloo, ON N2L 3C5
dc.description.affiliationFaculty of Medical Sciences Campinas State University, Campinas
dc.description.affiliationKinesiology Department University of Waterloo, ON
dc.format.extent369-380
dc.identifierhttp://dx.doi.org/10.1080/00222895.2013.810139
dc.identifier.citationJournal of Motor Behavior, v. 45, n. 5, p. 369-380, 2013.
dc.identifier.doi10.1080/00222895.2013.810139
dc.identifier.issn0022-2895
dc.identifier.issn1940-1027
dc.identifier.scopus2-s2.0-84887970256
dc.identifier.urihttp://hdl.handle.net/11449/219976
dc.language.isoeng
dc.relation.ispartofJournal of Motor Behavior
dc.sourceScopus
dc.subjectAdaptive gait
dc.subjectDopaminergic replacement
dc.subjectLocomotion
dc.subjectObstacle crossing
dc.subjectObstacle heights
dc.subjectParkinson's disease
dc.titleEvaluating the acute contributions of dopaminergic replacement to gait with obstacles in parkinson's diseaseen
dc.typeArtigo

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