Analysis of the biocompatibility of a biocelulose and a poly L-lactic acid membrane

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dc.contributor.authorNeto, José Doval
dc.contributor.authorMarques, Rodrigo Fernando Costa [UNESP]
dc.contributor.authorMotta, Adriana Cristina
dc.contributor.authorde Rezende Duek, Eliana Aparecida
dc.contributor.authorde Oliveira, Guilherme José Pimentel Lopes
dc.contributor.authorMarcantonio, Cláudio
dc.contributor.institutionAraraquara University Center (UNIARA)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.date.accessioned2023-07-29T14:12:55Z
dc.date.available2023-07-29T14:12:55Z
dc.date.issued2021-01-01
dc.description.abstractThe use of selective barriers as resorbable membranes has become a routine clinical procedure for guided bone regeneration. Therefore, the production of membranes with a low inflammatory potential during their resorption process has become the goal of a considerable number of researches. Aim: The purpose of the present study was to evaluate the biocompatibility of poly (L-lactic acid) (PLLA) and biocelulose membranes (BC) inserted in the subcutaneous tissue on the dorsum of rats. Methods: Fifteen animals underwent surgical procedures for the insertion of 4 types of membranes: COL (Collagen membrane) – Control Group; BC (Biocellulose membrane); BCAg (Biocellulose membrane impregnated with Silver); PLLA (Poly (L-lactic acid) membrane). All membrane types were inserted into each animal. Animals were euthanized after 3, 7, and 15 days of the surgical procedure. Descriptive histological analyses were carried out to investigate host tissue reaction to membrane presence by assessing the anti-inflammatory process composition associated with the membrane resorption and the presence of foreign-body reaction or encapsulation. Results: The BC membranes showed a higher degree of inflammation and poor pattern of integration with the surrounding tissues than the PLLA and COL membranes. Conclusion: The PLLA and COL membranes present better biocompatibility than the BC membranes.en
dc.description.affiliationAraraquara Dental School Department of Postgraduate Studies in Implantology Araraquara University Center (UNIARA)
dc.description.affiliationInstitute of Chemistry Paulista State University
dc.description.affiliationBiomaterials Laboratory Faculty of Medical Sciences and Health Pontifical Catholic University of São Paulo
dc.description.affiliationDepartment of Periodontology/ Implantodontology School of Dentistry Federal University of Uberlândia (UFU)
dc.description.affiliationUnespInstitute of Chemistry Paulista State University
dc.identifierhttp://dx.doi.org/10.20396/BJOS.V21I00.8670616
dc.identifier.citationBrazilian Journal of Oral Sciences, v. 21.
dc.identifier.doi10.20396/BJOS.V21I00.8670616
dc.identifier.issn1677-3225
dc.identifier.issn1677-3217
dc.identifier.scopus2-s2.0-85138663425
dc.identifier.urihttp://hdl.handle.net/11449/249195
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Oral Sciences
dc.sourceScopus
dc.subjectBiocompatible materials
dc.subjectCelulose
dc.subjectInflammation
dc.subjectMembranes
dc.subjectPolyesters
dc.titleAnalysis of the biocompatibility of a biocelulose and a poly L-lactic acid membraneen
dc.typeArtigo
unesp.author.orcid0000-0001-5298-5452[1]
unesp.author.orcid0000-0003-0195-3885[2]
unesp.author.orcid0000-0002-6306-8577[3]
unesp.author.orcid0000-0001-6327-7363[4]
unesp.author.orcid0000-0001-8778-0115[5]
unesp.author.orcid0000-0003-2179-2273[6]

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