Comparative study of disk diffusion and microdilution methods for evaluation of antifungal activity of natural compounds against medical yeasts Candida spp and Cryptococcus sp

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dc.contributor.authorScorzoni, L. [UNESP]
dc.contributor.authorBenaducci, T. [UNESP]
dc.contributor.authorAlmeida, A. M F [UNESP]
dc.contributor.authorSilva, Dulce Helena Siqueira [UNESP]
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorMendes-Giannini, Maria José Soares [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:43Z
dc.date.available2014-05-27T11:22:43Z
dc.date.issued2007-12-01
dc.description.abstractAntifungal activity of natural products has been tested by adapting methods designed for synthetic drugs. In this study, two methods for the determination of antifungal activity of natural products, agar diffusion and broth microdilution, the CLSI reference methods for synthetic drugs, are compared and discussed. The microdilution method was more sensitive. The minimal inhibitory concentrations (MIC) of crude extracts, fractions and pure substances from different species of the plant families Piperaceae, Rubiaceae, Clusiaceae, Fabaceae and Lauraceae, from the Biota project, were determined. Antifungal activities against Candida albicans, C.krusei, C.parapsilosis and Cryptococcus neoformans were produced by several samples.en
dc.description.affiliationDisciplina de Micologia Clínica Departemente de Análises Clínicas Universidade Estadual Paulista, UNESP, Araraquara, SP
dc.description.affiliationNuBBe - Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais Departamento de Química Orgânica Universidade Estadual Paulista, UNESP, Araraquara, SP
dc.description.affiliationLaboratório de Micologia Clínica Departamento de Análises Clínicas Universidade Estadual Paulista - UNESP, Rua Expedicionários do Brasil, 1602, CEP: 14801-902 - Araraquara - SP
dc.description.affiliationUnespDisciplina de Micologia Clínica Departemente de Análises Clínicas Universidade Estadual Paulista, UNESP, Araraquara, SP
dc.description.affiliationUnespNuBBe - Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais Departamento de Química Orgânica Universidade Estadual Paulista, UNESP, Araraquara, SP
dc.description.affiliationUnespLaboratório de Micologia Clínica Departamento de Análises Clínicas Universidade Estadual Paulista - UNESP, Rua Expedicionários do Brasil, 1602, CEP: 14801-902 - Araraquara - SP
dc.format.extent25-34
dc.identifierhttp://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/341
dc.identifier.citationRevista de Ciencias Farmaceuticas Basica e Aplicada, v. 28, n. 1, p. 25-34, 2007.
dc.identifier.file2-s2.0-39549090162.pdf
dc.identifier.issn1808-4532
dc.identifier.issn2179-443X
dc.identifier.lattes4702004904231248
dc.identifier.lattes4484083685251673
dc.identifier.orcid0000-0002-8059-0826
dc.identifier.orcid0000-0002-1516-7765
dc.identifier.scopus2-s2.0-39549090162
dc.identifier.urihttp://hdl.handle.net/11449/70145
dc.language.isoeng
dc.relation.ispartofRevista de Ciências Farmacêuticas Básica e Aplicada
dc.relation.ispartofsjr0,131
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntifungal activity
dc.subjectCandida sp
dc.subjectCryptococcus sp
dc.subjectNatural products
dc.subjectantifungal agent
dc.subjectclusiaceae extract
dc.subjectfabaceae extract
dc.subjectlauraceae extract
dc.subjectpiperaceae extract
dc.subjectplant extract
dc.subjectrubiaceae extract
dc.subjectunclassified drug
dc.subjectangiosperm
dc.subjectantibiotic sensitivity
dc.subjectantifungal activity
dc.subjectbroth dilution
dc.subjectCandida albicans
dc.subjectCandida krusei
dc.subjectCandida parapsilosis
dc.subjectcomparative study
dc.subjectCryptococcus neoformans
dc.subjectdisk diffusion
dc.subjectdrug activity
dc.subjectdrug determination
dc.subjectdrug screening
dc.subjectGuttiferae
dc.subjectlegume
dc.subjectminimum inhibitory concentration
dc.subjectnonhuman
dc.subjectPiperaceae
dc.subjectRubiaceae
dc.subjectsensitivity and sensibility
dc.subjectyeast
dc.titleComparative study of disk diffusion and microdilution methods for evaluation of antifungal activity of natural compounds against medical yeasts Candida spp and Cryptococcus spen
dc.typeArtigo
dcterms.licensehttp://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/about
unesp.author.lattes4702004904231248[4]
unesp.author.lattes4484083685251673
unesp.author.orcid0000-0002-8059-0826[6]
unesp.author.orcid0000-0002-1516-7765[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas
Artigos - Química Orgânica - IQ