Influence of the estrous cycle on the sensitivity to catecholamines in right atria from rats submitted to foot-shock stress

Página do item simplificado
dc.contributor.authorVanderlei, L. C M [UNESP]
dc.contributor.authorMarcondes, F. K.
dc.contributor.authorLanza, L. L B
dc.contributor.authorSpadari-Bratfisch, R. C.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-27T11:18:07Z
dc.date.available2014-05-27T11:18:07Z
dc.date.issued1996-11-23
dc.description.abstractWe investigated the mechanisms of the alterations in sensitivity to catecholamines in right atria from female rats exhibiting regular 4-day estrous cycles after three foot-shock sessions at estrus, metestrus, and diestrus or at diestrus, proestrus, and estrus. Right atria from stressed rats sacrificed at diestrus showed subsensitivity to noradrenaline and adrenaline. After in vitro sympathetic denervation (38 μM 6-hydroxydopamine) plus inhibition of neuronal reuptake (0.1 μM desipramine) subsensitivity to noradrenaline was abolished, but it was again evident when extraneuronal uptake was also inhibited (10 μM phenoxybenzamine and 30 μM corticosterone). The same pretreatment abolished the subsensitivity to adrenaline. After addition of 1 μM butoxamine, a β2-adrenoceptor antagonist, the tissues from stressed rats were subsensitive to adrenaline. Right atria from stressed rats sacrificed at estrus did not show any alteration in sensitivity to catecholamines. We conclude that after foot-shock stress, right atria from female rats sacrificed at diestrus showed subsensitivity of the chronotropic response to catecholamines as a result of a conformational alteration of β1-adrenoceptors, simultaneously with an increase in β2-adrenoceptor-mediated response. The mechanisms seem to be similar to those which underlie stress-induced alterations in catecholamine sensitivity in right atria from male rats. However, during estrus there are some protective factors that prevent the effects of stress on right atria.en
dc.description.affiliationDepartamento de Fisioterapia Faculdade de Cie. e Tecnologia Universidade Estadual Paulista, Presidente Prudente, São Paulo
dc.description.affiliationDepto. de Fisiol. e Biofísica Instituto de Biologia Universidade Estadual de Campinas, Campinas, São Paulo
dc.description.affiliationDentistry Graduate Program Faculdade de Odontol. de Piracicaba Universidade Estadual de Campinas, Piracicaba, São Paulo
dc.description.affiliationDepto. de Fisiol. e Biofísica Instituto de Biologia UNICAMP, 13081-970, Campinas, São Paulo
dc.description.affiliationUnespDepartamento de Fisioterapia Faculdade de Cie. e Tecnologia Universidade Estadual Paulista, Presidente Prudente, São Paulo
dc.format.extent670-678
dc.identifierhttp://dx.doi.org/10.1139/cjpp-74-6-670
dc.identifier.citationCanadian Journal of Physiology and Pharmacology, v. 74, n. 6, p. 670-678, 1996.
dc.identifier.doi10.1139/cjpp-74-6-670
dc.identifier.issn0008-4212
dc.identifier.lattes5860525135106995
dc.identifier.scopus2-s2.0-0029819914
dc.identifier.urihttp://hdl.handle.net/11449/64878
dc.identifier.wosWOS:A1996VP80100008
dc.language.isoeng
dc.relation.ispartofCanadian Journal of Physiology and Pharmacology
dc.relation.ispartofjcr2.210
dc.relation.ispartofsjr0,724
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAdrenaline
dc.subjectDiestrus
dc.subjectEstrus
dc.subjectFemale rats
dc.subjectFoot-shock stress
dc.subjectNoradrenaline
dc.subjectSubsensitivity
dc.subjectadrenalin
dc.subjectbutoxamine
dc.subjectcatecholamine derivative
dc.subjectcorticosterone
dc.subjectdesipramine
dc.subjectnoradrenalin
dc.subjectoxidopamine
dc.subjectphenoxybenzamine
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectchronotropism
dc.subjectcontrolled study
dc.subjectdenervation
dc.subjectdiestrus
dc.subjectdrug sensitivity
dc.subjectestrus cycle
dc.subjectfemale
dc.subjectheart right atrium
dc.subjectin vitro study
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectstress
dc.subjectAdrenergic beta-Antagonists
dc.subjectAnimals
dc.subjectAtrial Function
dc.subjectButoxamine
dc.subjectElectroshock
dc.subjectEpinephrine
dc.subjectFemale
dc.subjectHeart Atria
dc.subjectHeart Rate
dc.subjectNorepinephrine
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectStress
dc.titleInfluence of the estrous cycle on the sensitivity to catecholamines in right atria from rats submitted to foot-shock stressen
dc.typeArtigo
dcterms.licensehttp://www.nrcresearchpress.com/page/authors/information/rights
unesp.author.lattes5860525135106995
unesp.author.orcid0000-0002-1891-3153[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências e Tecnologia, Presidente Prudentept
unesp.departmentFisioterapia - FCTpt

Arquivos

Coleções

Presidente Prudente - FCT - Faculdade de Ciências e Tecnologia