Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp

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dc.contributor.authorSandoval Pacheco, Carmen M.
dc.contributor.authorAraujo Flores, Gabriela V.
dc.contributor.authorGonzalez, Kadir
dc.contributor.authorDe Castro Gomes, Claudia M.
dc.contributor.authorPassero, Luiz F. D. [UNESP]
dc.contributor.authorTomokane, Thaise Y.
dc.contributor.authorSosa-Ochoa, Wilfredo
dc.contributor.authorZúniga, Concepción
dc.contributor.authorCalzada, Jose
dc.contributor.authorSaldaña, Azael
dc.contributor.authorCorbett, Carlos E. P.
dc.contributor.authorSilveira, Fernando T.
dc.contributor.authorLaurenti, Marcia D.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionInstituto Conmemorativo Gorgas de Estudios de la Salud
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidad Nacional Autónoma de Honduras
dc.contributor.institutionHospital Escuela
dc.contributor.institutionUniversidad de Panamá
dc.contributor.institutionInstituto Evandro Chagas
dc.contributor.institutionUniversidade Federal do Pará (UFPA)
dc.date.accessioned2021-06-25T10:29:12Z
dc.date.available2021-06-25T10:29:12Z
dc.date.issued2021-01-01
dc.description.abstractMacrophages play important roles in the innate and acquired immune responses against Leishmania parasites. Depending on the subset and activation status, macrophages may eliminate intracellular parasites; however, these host cells also can offer a safe environment for Leishmania replication. In this sense, the fate of the parasite may be influenced by the phenotype of the infected macrophage, linked to the subtype of classically activated (M1) or alternatively activated (M2) macrophages. In the present study, M1 and M2 macrophage subsets were analyzed by double-staining immunohistochemistry in skin biopsies from patients with American cutaneous leishmaniasis (ACL) caused by L. (L.) amazonensis, L. (V.) braziliensis, L. (V.) panamensis,and L. (L.) infantum chagasi. High number of M1 macrophages was detected in nonulcerated cutaneous leishmaniasis (NUCL) caused by L. (L.) infantum chagasi (M1=112±12, M2=43±12 cells/mm2). On the other side, high density of M2 macrophages was observed in the skin lesions of patients with anergic diffuse cutaneous leishmaniasis (ADCL) (M1=195±25, M2=616±114), followed by cases of localized cutaneous leishmaniasis (LCL) caused by L. (L.) amazonensis (M1=97±24, M2=219±29), L. (V.) panamensis (M1=71±14, M2=164±14), and L. (V.) braziliensis (M1=50±13, M2=53±10); however, low density of M2 macrophages was observed in NUCL. The data presented herein show the polarization of macrophages in skin lesions caused by different Leishmania species that may be related with the outcome of the disease.en
dc.description.affiliationDepartamento de Patologia Laboratório de Patologia de Moléstias Infecciosas Faculdade de Medicina Universidade de São Paulo, Av. Doutor Arnaldo 455
dc.description.affiliationDepartamento de Parasitología Molecular Instituto Conmemorativo Gorgas de Estudios de la Salud, Ave. Justo Arosemena
dc.description.affiliationSão Paulo State University (UNESP) Institute of Biosciences Institute for Advanced Studies of Ocean
dc.description.affiliationInstituto de Investigación en Microbiología Universidad Nacional Autónoma de Honduras
dc.description.affiliationDepartamento de Vigilancia de la Salud Hospital Escuela
dc.description.affiliationFacultad de Medicina Veterinaria Universidad de Panamá Campus Harmodio Arias Madrid, Av. Juan Pablo II
dc.description.affiliationCentro de Investigación y Diagnóstico de Enfermedades Parasitarias Facultad de Medicina Universidad de Panamá, Ave. Octavio Méndez Pereira
dc.description.affiliationDepartamento de Parasitologia Instituto Evandro Chagas
dc.description.affiliationNúcleo de Medicina Tropical Universidade Federal de Pará
dc.description.affiliationUnespSão Paulo State University (UNESP) Institute of Biosciences Institute for Advanced Studies of Ocean
dc.identifierhttp://dx.doi.org/10.1155/2021/5596876
dc.identifier.citationJournal of Immunology Research, v. 2021.
dc.identifier.doi10.1155/2021/5596876
dc.identifier.issn2314-7156
dc.identifier.issn2314-8861
dc.identifier.scopus2-s2.0-85105017740
dc.identifier.urihttp://hdl.handle.net/11449/206262
dc.language.isoeng
dc.relation.ispartofJournal of Immunology Research
dc.sourceScopus
dc.titleMacrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania spen
dc.typeArtigo
unesp.author.orcid0000-0001-6566-4869[1]
unesp.author.orcid0000-0001-8560-7298[2]
unesp.author.orcid0000-0001-7297-1322[3]
unesp.author.orcid0000-0001-9909-9466[4]
unesp.author.orcid0000-0002-5986-6381[5]
unesp.author.orcid0000-0002-1431-6829[6]
unesp.author.orcid0000-0002-2622-792X[8]
unesp.author.orcid0000-0002-6669-4290 0000-0002-6669-4290[9]
unesp.author.orcid0000-0002-5653-1332 0000-0002-5653-1332[10]
unesp.author.orcid0000-0002-1080-2440[13]

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