Reproductive evaluations in female rat offspring exposed to metformin during intrauterine and intrauterine/lactational periods

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dc.contributor.authorForcato, Simone
dc.contributor.authorMontagnini, Bruno Garcia
dc.contributor.authorMarino de Goes, Maria Luiza
dc.contributor.authorBarrionuevo da Silva Novi, Daniella Regina
dc.contributor.authorInhasz Kiss, Ana Carolina
dc.contributor.authorCeravolo, Graziela Scalianti
dc.contributor.authorCeccatto Gerardin, Daniela Cristina
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionSeo Paulo State Univ
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-04T13:15:54Z
dc.date.available2019-10-04T13:15:54Z
dc.date.issued2019-08-01
dc.description.abstractMetformin (MET) is a widely-used drug for the treatment of type 2 diabetes mellitus and gestational diabetes. It is known that metformin crosses the placenta and can to be transferred through milk. In vitro studies show that MET decreases gonadotropin-releasing hormone and gonadotropins release in rat neurons, and decreases progesterone and estradiol in rat granulosa cells and androstenedione synthesis in human theca cells. This study evaluated whether MET maternal exposure might interfere with reproductive parameters of female offspring. Wistar female rats were treated with MET 293 mg/kg/day, by gavage, from gestational day (GD) 0 to GD 21 (METG) or GD 0 until lactation day (LD) 21 (METGL). Controls groups received water. An increase in plasmatic estradiol levels was observed during the estrus stage in the METGL group. This result suggests that exposure to MET during gestational and lactational periods might be related to programming in theca and/or granulosa cells during development.en
dc.description.affiliationUniv Estadual Londrina, Ctr Biol Sci, Dept Physiol Sci, Londrina, PR, Brazil
dc.description.affiliationSeo Paulo State Univ, Dept Physiol, Botucatu, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1-7
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2019.04.009
dc.identifier.citationReproductive Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 87, p. 1-7, 2019.
dc.identifier.doi10.1016/j.reprotox.2019.04.009
dc.identifier.issn0890-6238
dc.identifier.urihttp://hdl.handle.net/11449/186223
dc.identifier.wosWOS:000476575000001
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofReproductive Toxicology
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectAntidiabetic drug
dc.subjectMaternal exposure
dc.subjectEstrous cycle
dc.titleReproductive evaluations in female rat offspring exposed to metformin during intrauterine and intrauterine/lactational periodsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1490222400024738[5]
unesp.author.orcid0000-0002-8558-0141[5]

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