Development of natural polymeric microcapsules for antimicrobial drug delivery: triclosan loaded chitosan and alginate-based microcapsules
dc.contributor.author | Alves de Lima, Caroline Santos | |
dc.contributor.author | Costa Varca, Gustavo Henrique | |
dc.contributor.author | Costa, Sirlene Maria da | |
dc.contributor.author | Ferraz, Humberto Gomes | |
dc.contributor.author | Silva Santos, Ana Carolina da [UNESP] | |
dc.contributor.author | Lopes, Patricia Santos | |
dc.contributor.author | Costa, Silgia Aparecida da | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | IPEN CNEN SP | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
dc.date.accessioned | 2020-12-10T20:09:25Z | |
dc.date.available | 2020-12-10T20:09:25Z | |
dc.date.issued | 2020-08-20 | |
dc.description.abstract | The goal of this work was the development of natural polymeric microcapsules for antimicrobial drug delivery - triclosan loaded alginate and chitosan-based microcapsules for potential coating applications in substrates such as textiles or plastics. Microcapsules containing 2.5% (w/w) or 3% (w/w) triclosan in both core and matrix were synthesized and evaluated by Fourier-transform infrared spectroscopy, scanning electron microscopy, confocal microscopy, differential scanning calorimetry, thermogravimetry, and antimicrobial activity. The microcapsules produced featured spherical and mostly irregularly-shaped surfaces composed by an alginate core in a chitosan outer matrix, as revealed by confocal microscopy, and antimicrobial activity againstS. aureusandE. coliwith inhibition halos up to 60 mm and 25 mm respectively, granted by a triclosan loading of 61.66%. The thermal analysis suggested that the polymers protected the active substance from temperature-induced degradation. In conclusion, these microcapsules may be applied toward antimicrobial functionalization of plastics, textiles and other materials. | en |
dc.description.affiliation | Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo, Brazil | |
dc.description.affiliation | IPEN CNEN SP, Nucl & Energy Res Inst, Sao Paulo, Brazil | |
dc.description.affiliation | Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Sao Paulo, Brazil | |
dc.description.affiliation | State Univ Sao Paulo, Dept Microbiol & Immunol, Botucatu, SP, Brazil | |
dc.description.affiliation | Univ Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Diadema, Brazil | |
dc.description.affiliationUnesp | State Univ Sao Paulo, Dept Microbiol & Immunol, Botucatu, SP, Brazil | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorshipId | FAPESP: 2015/08845-5 | |
dc.format.extent | 1477-1486 | |
dc.identifier | http://dx.doi.org/10.1080/03639045.2020.1809445 | |
dc.identifier.citation | Drug Development And Industrial Pharmacy. Abingdon: Taylor & Francis Ltd, v. 46, n. 9, p. 1477-1486, 2020. | |
dc.identifier.doi | 10.1080/03639045.2020.1809445 | |
dc.identifier.issn | 0363-9045 | |
dc.identifier.uri | http://hdl.handle.net/11449/197204 | |
dc.identifier.wos | WOS:000561159600001 | |
dc.language.iso | eng | |
dc.publisher | Taylor & Francis Ltd | |
dc.relation.ispartof | Drug Development And Industrial Pharmacy | |
dc.source | Web of Science | |
dc.subject | Biopolymers | |
dc.subject | microparticles | |
dc.subject | antibacterial | |
dc.subject | chitosan | |
dc.subject | sodium alginate | |
dc.subject | triclosan | |
dc.title | Development of natural polymeric microcapsules for antimicrobial drug delivery: triclosan loaded chitosan and alginate-based microcapsules | en |
dc.type | Artigo | |
dcterms.license | http://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp | |
dcterms.rightsHolder | Taylor & Francis Ltd |