Development of natural polymeric microcapsules for antimicrobial drug delivery: triclosan loaded chitosan and alginate-based microcapsules

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dc.contributor.authorAlves de Lima, Caroline Santos
dc.contributor.authorCosta Varca, Gustavo Henrique
dc.contributor.authorCosta, Sirlene Maria da
dc.contributor.authorFerraz, Humberto Gomes
dc.contributor.authorSilva Santos, Ana Carolina da [UNESP]
dc.contributor.authorLopes, Patricia Santos
dc.contributor.authorCosta, Silgia Aparecida da
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionIPEN CNEN SP
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2020-12-10T20:09:25Z
dc.date.available2020-12-10T20:09:25Z
dc.date.issued2020-08-20
dc.description.abstractThe goal of this work was the development of natural polymeric microcapsules for antimicrobial drug delivery - triclosan loaded alginate and chitosan-based microcapsules for potential coating applications in substrates such as textiles or plastics. Microcapsules containing 2.5% (w/w) or 3% (w/w) triclosan in both core and matrix were synthesized and evaluated by Fourier-transform infrared spectroscopy, scanning electron microscopy, confocal microscopy, differential scanning calorimetry, thermogravimetry, and antimicrobial activity. The microcapsules produced featured spherical and mostly irregularly-shaped surfaces composed by an alginate core in a chitosan outer matrix, as revealed by confocal microscopy, and antimicrobial activity againstS. aureusandE. coliwith inhibition halos up to 60 mm and 25 mm respectively, granted by a triclosan loading of 61.66%. The thermal analysis suggested that the polymers protected the active substance from temperature-induced degradation. In conclusion, these microcapsules may be applied toward antimicrobial functionalization of plastics, textiles and other materials.en
dc.description.affiliationUniv Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo, Brazil
dc.description.affiliationIPEN CNEN SP, Nucl & Energy Res Inst, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Sao Paulo, Brazil
dc.description.affiliationState Univ Sao Paulo, Dept Microbiol & Immunol, Botucatu, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Diadema, Brazil
dc.description.affiliationUnespState Univ Sao Paulo, Dept Microbiol & Immunol, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2015/08845-5
dc.format.extent1477-1486
dc.identifierhttp://dx.doi.org/10.1080/03639045.2020.1809445
dc.identifier.citationDrug Development And Industrial Pharmacy. Abingdon: Taylor & Francis Ltd, v. 46, n. 9, p. 1477-1486, 2020.
dc.identifier.doi10.1080/03639045.2020.1809445
dc.identifier.issn0363-9045
dc.identifier.urihttp://hdl.handle.net/11449/197204
dc.identifier.wosWOS:000561159600001
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofDrug Development And Industrial Pharmacy
dc.sourceWeb of Science
dc.subjectBiopolymers
dc.subjectmicroparticles
dc.subjectantibacterial
dc.subjectchitosan
dc.subjectsodium alginate
dc.subjecttriclosan
dc.titleDevelopment of natural polymeric microcapsules for antimicrobial drug delivery: triclosan loaded chitosan and alginate-based microcapsulesen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Ltd

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