Development of natural polymeric microcapsules for antimicrobial drug delivery: triclosan loaded chitosan and alginate-based microcapsules


The goal of this work was the development of natural polymeric microcapsules for antimicrobial drug delivery - triclosan loaded alginate and chitosan-based microcapsules for potential coating applications in substrates such as textiles or plastics. Microcapsules containing 2.5% (w/w) or 3% (w/w) triclosan in both core and matrix were synthesized and evaluated by Fourier-transform infrared spectroscopy, scanning electron microscopy, confocal microscopy, differential scanning calorimetry, thermogravimetry, and antimicrobial activity. The microcapsules produced featured spherical and mostly irregularly-shaped surfaces composed by an alginate core in a chitosan outer matrix, as revealed by confocal microscopy, and antimicrobial activity againstS. aureusandE. coliwith inhibition halos up to 60 mm and 25 mm respectively, granted by a triclosan loading of 61.66%. The thermal analysis suggested that the polymers protected the active substance from temperature-induced degradation. In conclusion, these microcapsules may be applied toward antimicrobial functionalization of plastics, textiles and other materials.



Biopolymers, microparticles, antibacterial, chitosan, sodium alginate, triclosan

Como citar

Drug Development And Industrial Pharmacy. Abingdon: Taylor & Francis Ltd, v. 46, n. 9, p. 1477-1486, 2020.