Influence of beta-cyclodextrin on the properties of norfloxacin form A

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dc.contributor.authorChierentin, Lucas [UNESP]
dc.contributor.authorGarnero, Claudia
dc.contributor.authorChattah, Ana Karina
dc.contributor.authorDelvadia, Poonam
dc.contributor.authorKarnes, Thomas
dc.contributor.authorLonghi, Marcela Raquel
dc.contributor.authorSalgado, Herida Regina Nunes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidad Nacional de Córdoba
dc.contributor.institutionVirginia Commonwealth University
dc.date.accessioned2015-10-21T20:59:20Z
dc.date.available2015-10-21T20:59:20Z
dc.date.issued2015-06-01
dc.description.abstractCyclodextrins are able to form host-guest complexes with hydrophobic molecules to result in the formation of inclusion complexes. The complex formation between norfloxacin form A and beta-cyclodextrin was studied by exploring its structure affinity relationship in an aqueous solution and in the solid state. Kneading, freeze-drying, and physical mixture methods were employed to prepare solid complexes of norfloxacin and beta-cyclodextrin. The solubility of norfloxacin significantly increased upon complexation with beta-cyclodextrin as demonstrated by a solubility isotherm of the AL type along with the results of an intrinsic dissolution study. The complexes were also characterized in the solid stated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffractometry, scanning electron microscopy (SEM), and solid-state nuclear magnetic resonance (ssNMR) spectrometry. The thermal analysis showed that the thermal stability of the drug is enhanced in the presence of beta-cyclodextrin. Finally, the microbiological studies showed that the complexes have better potency when compared with pure drug.en
dc.description.affiliationUniversidad Nacional Cordoba, Departamento de Farmacia, Faculdad Ciencias Químicas
dc.description.affiliationUniversidad Nacional Cordoba, Facultad de Matemática, Astronomía y Física
dc.description.affiliationVirginia Commonwealth University, Department of Pharmaceutics, School of Pharmacy
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas de Araraquara
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipConsejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
dc.description.sponsorshipSecretaria de Ciencia y Tecnica de la Universidad Nacional de Cordoba (SECyT-UNC)
dc.description.sponsorshipMinisterio de Ciencia y Tecnologia (MinCyT) de la Provincia de Cordoba
dc.description.sponsorshipIdFAPESP: 2010/13335-2
dc.format.extent683-691
dc.identifierhttp://link.springer.com/article/10.1208%2Fs12249-014-0259-8
dc.identifier.citationAaps Pharmscitech. New York: Springer, v. 16, n. 3, p. 683-691, 2015.
dc.identifier.doi10.1208/s12249-014-0259-8
dc.identifier.issn1530-9932
dc.identifier.urihttp://hdl.handle.net/11449/129388
dc.identifier.wosWOS:000357567600021
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofAaps Pharmscitech
dc.relation.ispartofjcr2.666
dc.relation.ispartofsjr0,752
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBioassayen
dc.subjectComplexationen
dc.subjectIntrinsic dissolutionen
dc.subjectNorfloxacinen
dc.subjectBeta-cyclodextrinen
dc.titleInfluence of beta-cyclodextrin on the properties of norfloxacin form Aen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas