Reaction of the Phytochemistry Community to Green Chemistry: Insights Obtained Since 1990

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dc.contributor.authorFunari, Cristiano S. [UNESP]
dc.contributor.authorRinaldo, Daniel [UNESP]
dc.contributor.authorBolzani, Vanderlan S. [UNESP]
dc.contributor.authorVerpoorte, Robert
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionLeiden University
dc.date.accessioned2023-07-29T16:03:06Z
dc.date.available2023-07-29T16:03:06Z
dc.date.issued2023-02-24
dc.description.abstractThis review article aims to study how phytochemists have reacted to green chemistry insights since 1990, the year when the U.S. Environmental Protection Agency launched the “Pollution Prevention Act”. For each year in the period 1990 to 2019, three highly cited phytochemistry papers that provided enough information about the experimental procedures utilized were sampled. The “greenness” of these procedures was assessed, particularly for the use of solvents. The highly hazardous diethyl ether, benzene, and carbon tetrachloride did not appear in the papers sampled after 2010. Advances in terms of sustainability were observed mainly in the extraction stage. Similar progress was not observed in purification procedures, where chloroform, dichloromethane, and hexane regularly have been employed. Since replacing such solvents in purification procedures should be a major goal, potential alternative approaches are discussed. Moreover, some current initiatives toward a more sustainable phytochemical research considering aspects other than only solvents are highlighted. Although some advances have been achieved, it is believed that natural products chemists can play a major role in developing a novel ecological paradigm in chemistry. To contribute to this objective, six principles for performing natural products chemistry consistent with the guidelines of green chemistry are proposed.en
dc.description.affiliationGreen Biotech Network School of Agricultural Sciences São Paulo State University (UNESP)
dc.description.affiliationGreen Biotech Network School of Sciences São Paulo State University (UNESP)
dc.description.affiliationNuBBE Institute of Chemistry São Paulo State University (UNESP)
dc.description.affiliationNatural Products Laboratory Institute of Biology Leiden University
dc.description.affiliationUnespGreen Biotech Network School of Agricultural Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespGreen Biotech Network School of Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespNuBBE Institute of Chemistry São Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUniversity of South Alabama
dc.format.extent440-459
dc.identifierhttp://dx.doi.org/10.1021/acs.jnatprod.2c00501
dc.identifier.citationJournal of Natural Products, v. 86, n. 2, p. 440-459, 2023.
dc.identifier.doi10.1021/acs.jnatprod.2c00501
dc.identifier.issn1520-6025
dc.identifier.issn0163-3864
dc.identifier.scopus2-s2.0-85146381957
dc.identifier.urihttp://hdl.handle.net/11449/249560
dc.language.isoeng
dc.relation.ispartofJournal of Natural Products
dc.sourceScopus
dc.titleReaction of the Phytochemistry Community to Green Chemistry: Insights Obtained Since 1990en
dc.typeResenha
unesp.author.orcid0000-0003-0143-9448[1]
unesp.author.orcid0000-0001-7019-5825[3]
unesp.author.orcid0000-0001-6180-1424[4]

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