Cytokeratin profile in exfoliative cytology of smokers

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dc.contributor.authorLima, Celina Faig [UNESP]
dc.contributor.authorLeite, Sabrina Ferreira Pinotti [UNESP]
dc.contributor.authorCarvalho, Yasmin Rodarte [UNESP]
dc.contributor.authorCabral, Luiz Antonio Guimarães [UNESP]
dc.contributor.authorBalducci, Ivan [UNESP]
dc.contributor.authorAlmeida, Janete Dias [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T22:02:12Z
dc.date.available2022-04-28T22:02:12Z
dc.date.issued2011-02-01
dc.description.abstractOBJECTIVE: To compare the expression of cytokeratins (CKs) 6, 16, 19 and pan-cytokeratin (PAN) in oral mucosa cells between smokers and nonsmokers to determine the proliferative activity and expression indicative of a potential for malignant transformation. STUDY DESIGN: Smears were obtained from the left lateral border of the tongue with a cytobrush from 25 smokers and 20 nonsmokers seen at the clinics of São José dos Campos Dental School, São Paulo State University, São José dos Campos, São Paulo, Brazil, and processed for immunohistochemistry. Conventional microscopy was used for qualitative analysis. Proportions were compared statistically by the z-test and Fisher's exact test. RESULTS: The expression of CK6 (p = 0.002), CK16 (p=0.003), CK19 (p=0.0001) and PAN (p = 0.008) was higher in oral mucosa smears from smokers compared to nonsmokers. CONCLUSION: The expression of CK6 and CK16 demonstrated increased epithelial proliferation in the oral mucosa of smokers, and expression of CK19 indicated alterations in epithelial maturation. The expression of PAN indicates the need for the investigation of other types of CK in further studies. © Science Printers and Publishers, Inc.en
dc.description.affiliationPostgraduation Program in Oral Biopathology São José Dos Campos Dental School São Paulo State University, São José dos Campos, São Paulo
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis São José Dos Campos Dental School São Paulo State University, São José dos Campos, São Paulo
dc.description.affiliationDepartment of Social Science and Pediatric Dentistry São José Dos Campos Dental School São Paulo State University, São José dos Campos, São Paulo
dc.description.affiliationUnespPostgraduation Program in Oral Biopathology São José Dos Campos Dental School São Paulo State University, São José dos Campos, São Paulo
dc.description.affiliationUnespDepartment of Biosciences and Oral Diagnosis São José Dos Campos Dental School São Paulo State University, São José dos Campos, São Paulo
dc.description.affiliationUnespDepartment of Social Science and Pediatric Dentistry São José Dos Campos Dental School São Paulo State University, São José dos Campos, São Paulo
dc.format.extent19-24
dc.identifier.citationAnalytical and Quantitative Cytology and Histology, v. 33, n. 1, p. 19-24, 2011.
dc.identifier.issn0884-6812
dc.identifier.scopus2-s2.0-79951610207
dc.identifier.urihttp://hdl.handle.net/11449/226222
dc.language.isoeng
dc.relation.ispartofAnalytical and Quantitative Cytology and Histology
dc.sourceScopus
dc.subjectCytodiagnosis
dc.subjectImmunohistochemistry
dc.subjectKeratins
dc.subjectOral mucosa
dc.subjectSmoking
dc.titleCytokeratin profile in exfoliative cytology of smokersen
dc.typeArtigo

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Artigos - Biociências e Diagnóstico Bucal - ICT
Artigos - Odontologia Social e Clínica Infantil - ICT