Ultrastructural changes on the epithelial cells of uterine tubes of Wistar rats after chronic ethanol ingestion

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dc.contributor.authorMartinez, Marcelo
dc.contributor.authorBranco, A. C.
dc.contributor.authorCagnon, V. H. A.
dc.contributor.authorMello, W.
dc.contributor.authorGarcia, P. J.
dc.contributor.authorMartinez, F. E.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:19:43Z
dc.date.available2014-05-27T11:19:43Z
dc.date.issued1999-04-01
dc.description.abstractThe present paper describes the morphological alterations of the epithelial layer of the uterine tubes of rats submitted to experimental chronic alcoholism using anatomical, histological, ultrastructural and morphometric methods. Sixty adult rats (Rattus norvegicus albinus) at the same age (3 months) and with a mean body weight of 228 g were divided into two groups. The control group received solid diet (Purina rat chow) and tap water ad libitum. The alcoholic group received the same solid diet and was allowed to drink only sugar cane brandy dissolved in 30° Gay Lussac (v/v). After periods of 90, 180 and 270 days of treatment animals at normal estrus were anaesthetised with ethyl ether, weighed and sacrificed. Subsequently, the uterine tubes were dissected, weighed and prepared for TEM and SEM methods. The final mean body weights were similar in the control and alcoholic groups. The morphometric analysis showed no difference between control and alcoholic epithelial height. The alcoholic animals showed ultrastructural alterations: intense lipid droplet and lysosomes accumulation, dilated rough endoplasmic reticulum cisternae and vacuolization in both periods of treatment. It was concluded that alcohol acts as a toxin on the epithelial layer of the uterine tubes of rats.en
dc.description.affiliationDepartment of Anatomy State University of São Paulo, Botucatu, SP
dc.description.affiliationDepartamento de Anatomia Univ. do Estado de São; Paulo, Rubião Júnior s/n, CEP 18618000, Botucatu, SP
dc.format.extent273-278
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10457613
dc.identifier.citationJournal of Submicroscopic Cytology and Pathology, v. 31, n. 2, p. 273-278, 1999.
dc.identifier.issn1122-9497
dc.identifier.scopus2-s2.0-0033110081
dc.identifier.urihttp://hdl.handle.net/11449/65758
dc.language.isoeng
dc.relation.ispartofJournal of Submicroscopic Cytology and Pathology
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAlcoholism
dc.subjectEpithelium
dc.subjectSEM
dc.subjectUterine tubes
dc.subjectanimal
dc.subjectcomparative study
dc.subjectdrinking behavior
dc.subjectdrug effect
dc.subjectelectron microscopy
dc.subjectepithelium cell
dc.subjectfemale
dc.subjectpathology
dc.subjectrat
dc.subjecttime
dc.subjectultrastructure
dc.subjectuterine tube
dc.subjectWistar rat
dc.subjectAlcohol Drinking
dc.subjectAnimals
dc.subjectEpithelial Cells
dc.subjectFallopian Tubes
dc.subjectFemale
dc.subjectMicroscopy, Electron
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTime Factors
dc.titleUltrastructural changes on the epithelial cells of uterine tubes of Wistar rats after chronic ethanol ingestionen
dc.typeArtigo

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