Eosinophilia and elevated IgE serum levels: a red flag: when your diagnosis is not a common atopic eczema or common allergy

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dc.contributor.authorCriado, Paulo Ricardo [UNESP]
dc.contributor.authorMiot, Hélio Amante [UNESP]
dc.contributor.authorIanhez, Mayra
dc.contributor.institutionFull Researcher
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2023-07-29T16:02:51Z
dc.date.available2023-07-29T16:02:51Z
dc.date.issued2023-03-01
dc.description.abstractObjective and design: The hallmark of type 2 inflammation is eosinophilia and/or high IgE serum levels, mostly in atopic dermatitis. Nevertheless, many dermatoses may present similar findings. Our aim is to explore the biological and clinical spectrum of cutaneous manifestations involving tissue and/or systemic eosinophilia, and distinct serum levels of IgE, where atopic dermatitis or other primary allergic eczema, not always is the definitive diagnosis. Materials/methods: A total of 37 scientific papers were enrolled in this narrative review. Results: A diagnostic approach for patients with elevated serum IgE level and a list of conditions not related to atopic dermatitis that runs through inborn errors of immunity, inflammatory disorders, lung disorders, malignancy, infections/infestations are displayed. Regarding to peripheral eosinophilia, differential diagnosis is also explored and clinical patterns of skin diseases associated with tissue eosinophilia are listed, to facilitate our diagnosis. Conclusions: We should maintain a high level of suspicion about other differential diagnosis involving eosinophilia and IgE dysregulation, especially in patients very young (when innate errors of the immunity may present) and in middle to elderly patients classified as having atopic dermatitis, due to the possibility of cutaneous hematological malignancies, paraneoplasia or autoimmune blistering diseases.en
dc.description.affiliationFaculdade de Medicina do ABC Post-Graduation Program Full Researcher, Rua Carneiro Leão 33, Vila Scarpelli, Santo André
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Botucatu
dc.description.affiliationUniversidade Federal de Goiás (UFG) e Hospital de Doenças Tropicais (HDT-GO), Goiás
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Botucatu
dc.format.extent541-551
dc.identifierhttp://dx.doi.org/10.1007/s00011-023-01690-7
dc.identifier.citationInflammation Research, v. 72, n. 3, p. 541-551, 2023.
dc.identifier.doi10.1007/s00011-023-01690-7
dc.identifier.issn1420-908X
dc.identifier.issn1023-3830
dc.identifier.scopus2-s2.0-85146233184
dc.identifier.urihttp://hdl.handle.net/11449/249553
dc.language.isoeng
dc.relation.ispartofInflammation Research
dc.sourceScopus
dc.subjectAtopic
dc.subjectAutoimmunity
dc.subjectDermatitis
dc.subjectEosinophilia
dc.subjectHematological malignancy
dc.subjectImmunoglobulin E
dc.subjectImmunologic deficiency syndromes
dc.titleEosinophilia and elevated IgE serum levels: a red flag: when your diagnosis is not a common atopic eczema or common allergyen
dc.typeResenha
unesp.author.orcid0000-0001-9785-6099[1]
unesp.author.orcid0000-0002-2596-9294[2]
unesp.author.orcid0000-0003-3604-3128[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentDermatologia e Radioterapia - FMBpt

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Botucatu - FMB - Faculdade de Medicina