Transcranial doppler as screening method for sickling crises in children with sickle cell anemia: a latin America cohort study
dc.contributor.author | Modolo, Gabriel Pinheiro [UNESP] | |
dc.contributor.author | Luvizutto, Gustavo José | |
dc.contributor.author | Hamamoto Filho, Pedro Tadao [UNESP] | |
dc.contributor.author | Braga, Gabriel Pereira | |
dc.contributor.author | Bazan, Silmeia Garcia Zanati [UNESP] | |
dc.contributor.author | Ferreira, Natalia Cristina [UNESP] | |
dc.contributor.author | de Souza, Juli Thomaz [UNESP] | |
dc.contributor.author | Winckler, Fernanda Cristina [UNESP] | |
dc.contributor.author | Macedo de Freitas, Carlos Clayton [UNESP] | |
dc.contributor.author | Hokama, Newton Key [UNESP] | |
dc.contributor.author | Vidal, Edison Iglesias de Oliveira [UNESP] | |
dc.contributor.author | Bazan, Rodrigo [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | Universidade Federal Do Triângulo Mineiro (UFTM) | |
dc.contributor.institution | Universidade Federal de Mato Grosso do Sul (UFMS) | |
dc.date.accessioned | 2023-03-01T20:53:12Z | |
dc.date.available | 2023-03-01T20:53:12Z | |
dc.date.issued | 2022-12-01 | |
dc.description.abstract | Background: Sickle cell anemia (SCA) is the leading cause of childhood stroke. We aimed to evaluate whether altered cerebral flow velocities, as measured by transcranial Doppler (TCD), are associated with vaso-occlusive complications in addition to stroke in pediatric SCA patients. Methods: We evaluated 37 children aged between 2 and 16 years with SCA who underwent screening for TCD between January 2012 and October 2018. Genotypic profiles and demographic data were collected, TCD examinations were performed during follow-up, and the presence of sickling crises was compared. Survival analyses were performed using simple frailty models, in which each predictor variable was analyzed separately in relation to the occurrence of a sickling crisis. Results: The variables related to sickle cell crises in the univariate analysis were peak systolic velocity (PSV) in the middle cerebral artery (MCA), hazard ratio (HR) 1.01 (1.00—1.02) p = 0.04; end-diastolic velocity (EDV) in the MCA, HR 1.02 (1.01—1.04) p = 0.01; time average mean maximum velocity (TAMMV) in the basilar artery (BA), HR 1.02 (1.00—1.04) p = 0.04; hemoglobin, HR 0.49 (0.38—0.65) p < 0.001; hematocrit, HR 0.78 (0.71—0.85) p < 0.001; leukocyte counts, HR 1.1 (1.05—1.15) p < 0.001; platelets counts, HR 0.997 (0.994—0.999) p = 0.02; and reticulocyte numbers, HR 1.14 (1.06—1.23) p < 0.001. Conclusions: Our results indicate PSV and EDV in the MCA and TAMMV in the BA as markers of risk for the occurrence of sickling crises in SCA. | en |
dc.description.affiliation | Departmento de Neurologia Psicologia e Psiquiatria Universidade Estadual Paulista (UNESP) | |
dc.description.affiliation | Departmento de Fisioterapia Aplicada Universidade Federal Do Triângulo Mineiro (UFTM), Minas Gerais | |
dc.description.affiliation | Faculdade de Medicina Universidade Federal de Mato Grosso Do Sul (UFMS), Mato Grosso Do Sul | |
dc.description.affiliation | Departamento de Clínica Médica Universidade Estadual Paulista (UNESP) | |
dc.description.affiliationUnesp | Departmento de Neurologia Psicologia e Psiquiatria Universidade Estadual Paulista (UNESP) | |
dc.description.affiliationUnesp | Departamento de Clínica Médica Universidade Estadual Paulista (UNESP) | |
dc.identifier | http://dx.doi.org/10.1186/s12887-022-03429-5 | |
dc.identifier.citation | BMC Pediatrics, v. 22, n. 1, 2022. | |
dc.identifier.doi | 10.1186/s12887-022-03429-5 | |
dc.identifier.issn | 1471-2431 | |
dc.identifier.scopus | 2-s2.0-85132963852 | |
dc.identifier.uri | http://hdl.handle.net/11449/241243 | |
dc.language.iso | eng | |
dc.relation.ispartof | BMC Pediatrics | |
dc.source | Scopus | |
dc.subject | Sickle cell anemia | |
dc.subject | Stroke | |
dc.subject | Transcranial Doppler | |
dc.title | Transcranial doppler as screening method for sickling crises in children with sickle cell anemia: a latin America cohort study | en |
dc.type | Artigo | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatu | pt |
unesp.department | Neurologia, Psicologia e Psiquiatria - FMB | pt |