The osteogenic effects of swimming on bone mass, strength, and microarchitecture in rats with unloading-induced bone loss

Página do item simplificado
dc.contributor.authorVolpon, Jose Batista
dc.contributor.authorSilva, Adriana Valadares
dc.contributor.authorFalcai, Mauricio Jose
dc.contributor.authorLouzada, Mario Jefferson Quirino
dc.contributor.authorZamarioli, Ariane
dc.contributor.authorKotake, Bruna Gabriela Dos Santos
dc.contributor.authorIssa, João Paulo Mardegan
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-28T19:01:31Z
dc.date.available2022-04-28T19:01:31Z
dc.date.issued2015-01-01
dc.description.abstractThe effect of nonweight-bearing exercise on osteoporotic bones remains controversial and inconclusive. The purpose of this study was to evaluate the effects of swimming on osteoporotic tibias of rats submitted to hindlimb suspension. Initially, 20 Wistar rats were used to confirm a significant bone loss following 21 days of unloading. Thirty rats were then divided into 3 groups and followed during 51 days: CON (nonsuspended rats), S+WB (suspended rats for 21 days and then released for regular weight-bearing) and, S+Swim (suspended rats for 21 days and then released from suspension and submitted to swimming exercise). We observed that swimming exercise was effective at fully recovering the bone deterioration caused by suspension, with significant increments in BMD, bone strength and bone volume. On the other hand, regular weight-bearing failed at fully restoring the bone loss induced by unloading. These results indicate that swimming exercise may be a potential tool to improve bone density, strength, and trabecular volume in tibias with bone loss induced by mechanical unloading in suspended rats. We conclude that this modality of activity could be beneficial in improving bone mass, strength, and architecture in osteoporotic individuals induced by disuse, such as bed rest or those exposed to microgravity, who may not be able to perform weight-bearing exercises.en
dc.description.affiliationDepartment of Biomechanics, Medicine and Rehabilitation, School of Medicine of Ribeirão Preto, University of São Paulo
dc.description.affiliationDepartment of Production and Health Animal, University of São Paulo State
dc.description.affiliationDepartment of Morphology, Physiology and Basic Pathology, University of São Paulo
dc.format.extent784-791
dc.identifierhttp://dx.doi.org/10.1002/jemt.22541
dc.identifier.citationMicroscopy Research and Technique, v. 78, n. 9, p. 784-791, 2015.
dc.identifier.doi10.1002/jemt.22541
dc.identifier.issn1097-0029
dc.identifier.issn1059-910X
dc.identifier.scopus2-s2.0-84939651742
dc.identifier.urihttp://hdl.handle.net/11449/220437
dc.language.isoeng
dc.relation.ispartofMicroscopy Research and Technique
dc.sourceScopus
dc.subjectBone tissue
dc.subjectHindlimb suspension
dc.subjectNonweight-bearing exercise
dc.subjectOsteoporosis
dc.titleThe osteogenic effects of swimming on bone mass, strength, and microarchitecture in rats with unloading-induced bone lossen
dc.typeArtigo

Arquivos

Coleções

Artigos