International Consensus for the Dosing of Corticosteroids in Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis

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dc.contributor.authorChalhoub, Nathalie E.
dc.contributor.authorWenderfer, Scott E.
dc.contributor.authorLevy, Deborah M.
dc.contributor.authorRouster-Stevens, Kelly
dc.contributor.authorAggarwal, Amita
dc.contributor.authorSavani, Sonia I.
dc.contributor.authorRuth, Natasha M.
dc.contributor.authorArkachaisri, Thaschawee
dc.contributor.authorQiu, Tingting
dc.contributor.authorMerritt, Angela
dc.contributor.authorOnel, Karen
dc.contributor.authorGoilav, Beatrice
dc.contributor.authorKhubchandani, Raju P.
dc.contributor.authorDeng, Jianghong
dc.contributor.authorFonseca, Adriana R.
dc.contributor.authorArdoin, Stacy P.
dc.contributor.authorCiurtin, Coziana
dc.contributor.authorKasapcopur, Ozgur
dc.contributor.authorJelusic, Marija
dc.contributor.authorHuber, Adam M.
dc.contributor.authorOzen, Seza
dc.contributor.authorKlein-Gitelman, Marisa S.
dc.contributor.authorAppenzeller, Simone
dc.contributor.authorCavalcanti, André
dc.contributor.authorFotis, Lampros
dc.contributor.authorLim, Sern Chin
dc.contributor.authorSilva, Rodrigo M.
dc.contributor.authorMiramontes, Julia Ramírez-
dc.contributor.authorRosenwasser, Natalie L.
dc.contributor.authorSaad-Magalhaes, Claudia [UNESP]
dc.contributor.authorSchonenberg-Meinema, Dieneke
dc.contributor.authorScott, Christiaan
dc.contributor.authorSilva, Clovis A.
dc.contributor.authorEnciso, Sandra
dc.contributor.authorTerreri, Maria T.
dc.contributor.authorTorres-Jimenez, Alfonso-Ragnar
dc.contributor.authorTrachana, Maria
dc.contributor.authorAl-Mayouf, Sulaiman M.
dc.contributor.authorDevarajan, Prasad
dc.contributor.authorHuang, Bin
dc.contributor.authorBrunner, Hermine I.
dc.contributor.authorAbulaban, Khalid
dc.contributor.authorAguiar, Cassyanne
dc.contributor.authorAhn, Sun-Young
dc.contributor.authorAkoghlanian, Shoghik
dc.contributor.authorAl-Abrawi, Safiya
dc.contributor.authorAljaberi, Najla
dc.contributor.authorAlperin, Risa
dc.contributor.authorAngeles-Han, Sheila
dc.contributor.authorArdalan, Kaveh
dc.contributor.authorBader-Meunier, Brigitte
dc.contributor.authorBalboni, Imelda
dc.contributor.authorBarbar-Smiley, Fatima
dc.contributor.authorBaxter, Sarah
dc.contributor.authorBeary, John
dc.contributor.authorBoneparth, Alexis
dc.contributor.authorBrakeman, Paul
dc.contributor.authorBridges, John
dc.contributor.authorBurgos-Vargas, Ruben
dc.contributor.authorCabral, David A.
dc.contributor.authorCameto, Juan
dc.contributor.authorCarter, Caitlin
dc.contributor.authorChang, Joyce
dc.contributor.authorChédeville, Gaëlle
dc.contributor.authorChhakchhuak, Christine
dc.contributor.authorChiraseveenuprapund, Peter
dc.contributor.authorCifuentes Alvarado, Mayra
dc.contributor.authorConcannon, Anthony
dc.contributor.authorCooper, Jennifer
dc.contributor.authorCron, Randy
dc.contributor.authorDe Carvalho, Luciana Martins
dc.contributor.authorDe Quattro, Kimberly
dc.contributor.authorDe Ranieri, Deirdre
dc.contributor.authorDizon, Brian
dc.contributor.authorDonnelly Wrigley, Catherine
dc.contributor.authorDuong, Minh Dien
dc.contributor.authorEberhard, Anne
dc.contributor.authorEde, Kaleo
dc.contributor.authorEdelheit, Barbara
dc.contributor.authorEdens, Cuoghi
dc.contributor.authorEspada, Graciela
dc.contributor.authorFarhey, Yolanda
dc.contributor.authorFlores, Francisco
dc.contributor.authorFritz, Deborah
dc.contributor.authorGanguli, Suhas
dc.contributor.authorGilbert, Mileka
dc.contributor.authorGittar, Patsy
dc.contributor.authorGreenbaum, Larry
dc.contributor.authorGrom, Alexei
dc.contributor.authorGulati, Gaurav
dc.contributor.authorHarry, Onengiya
dc.contributor.authorHayward, Kristen
dc.contributor.authorHenrickson, Michael
dc.contributor.authorHersh, Aimee
dc.contributor.authorHiraki, Linda
dc.contributor.authorHiskey, Megan
dc.contributor.authorHoffmann, Sarah
dc.contributor.authorHollander, Matthew
dc.contributor.authorHom, Christine
dc.contributor.authorHouk, Lawrence
dc.contributor.authorHouk, J. Brian
dc.contributor.authorHsieh, Elena W.Y.
dc.contributor.authorHsu, Joyce
dc.contributor.authorJensen, Paul
dc.contributor.authorJoos, Rik
dc.contributor.authorJurado, Rosario
dc.contributor.authorJusan Fiorot, Fernanda
dc.contributor.authorKallash, Mahmoud
dc.contributor.authorKamphuis, Sylvia
dc.contributor.authorKeltsev, Vladimir
dc.contributor.authorKhanna, Surabhi
dc.contributor.authorKim, Susan
dc.contributor.authorKimseng, Karen Joy
dc.contributor.authorKnight, Andrea
dc.contributor.authorKunder, Rebecca
dc.contributor.authorLai, Jamie
dc.contributor.authorLaskin, Benjamin
dc.contributor.authorLewandowski, Laura
dc.contributor.authorLim, Lily
dc.contributor.authorLinda, Wagner-Weiner
dc.contributor.authorLo, Mindy
dc.contributor.authorLovell, Daniel
dc.contributor.authorLuggen, Michael
dc.contributor.authorMadison, Jacqueline
dc.contributor.authorMansuri, Asif
dc.contributor.authorMartin, Lorena
dc.contributor.authorMason, Sherene
dc.contributor.authorMiller, Michael
dc.contributor.authorMina, Rina
dc.contributor.authorMohammed, Abdul
dc.contributor.authorMoncrieffe, Halima
dc.contributor.authorMoorthy, Lakshmi
dc.contributor.authorMorgan, Esi
dc.contributor.authorMosquera, Angela
dc.contributor.authorMuntel, Emily
dc.contributor.authorMuscal, Eyal
dc.contributor.authorMyones, Barry
dc.contributor.authorNocton, James
dc.contributor.authorOgbu, Ekemini
dc.contributor.authorOkamura, Daryl
dc.contributor.authorOlson, Judyann
dc.contributor.authorOrrock, Janet
dc.contributor.authorPaim-Marques, Luciana
dc.contributor.authorPain, Clare
dc.contributor.authorPark, Catherine
dc.contributor.authorPatel, Pooja
dc.contributor.authorPereira, Maria
dc.contributor.authorPrado, Rogerio do
dc.contributor.authorRadhakrishna, Suhas
dc.contributor.authorRheault, Michelle
dc.contributor.authorRidgway, William
dc.contributor.authorRiskalla, Mona
dc.contributor.authorRonis, Tova
dc.contributor.authorSadun, Rebecca
dc.contributor.authorSagcal-Gironella, Anna Carmela
dc.contributor.authorSantos, Maria carolina
dc.contributor.authorSchikler, Kenneth
dc.contributor.authorAL Suwairi, Wafaa
dc.contributor.authorSiddiqi, Nabeela
dc.contributor.authorSilva, Marco Felipe
dc.contributor.authorSingh-Grewal, Davinder
dc.contributor.authorSmitherman, Emily
dc.contributor.authorSmolewska, Elzbieta
dc.contributor.authorSon, Mary Beth
dc.contributor.authorSrinivasalu, Hemalatha
dc.contributor.authorSule, Sangeeta
dc.contributor.authorSusic, Gordana
dc.contributor.authorSyed, Reema
dc.contributor.authorThatayatikom, Akaluck
dc.contributor.authorTing, Tracy
dc.contributor.authorToth, Mary
dc.contributor.authorTurnier, Jessica
dc.contributor.authorVashisht, Priyanka
dc.contributor.authorVega Fernandez, Patricia
dc.contributor.authorVelasquez, Monica
dc.contributor.authorvon Scheven, Emily
dc.contributor.authorWahezi, Dawn
dc.contributor.authorWare, Avis
dc.contributor.authorWu, Eveline
dc.contributor.authorYan, Jacqueline
dc.contributor.authorYildirim-Toruner, Cagri
dc.contributor.authorZamparo, Celso
dc.contributor.authorZhang, Yujuan
dc.contributor.authorLawson, Erica
dc.contributor.institutionUniversity of Cincinnati College of Medicine
dc.contributor.institutionBaylor College of Medicine
dc.contributor.institutionThe Hospital for Sick Children and The University of Toronto
dc.contributor.institutionEmory University and Children's Healthcare of Atlanta
dc.contributor.institutionSanjay Gandhi Postgraduate Institute of Medical Sciences
dc.contributor.institutionMedical University of South Carolina
dc.contributor.institutionKK Women's and Children's Hospital
dc.contributor.institutionCincinnati Children's Hospital Medical Center
dc.contributor.institutionHospital for Special Surgery
dc.contributor.institutionAlbert Einstein College of Medicine
dc.contributor.institutionSRCC Children's Hospital
dc.contributor.institutionCapital Medical University and National Center for Children's Health
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionNationwide Children's Hospital
dc.contributor.institutionUniversity College London
dc.contributor.institutionIstanbul University-Cerrahpasa
dc.contributor.institutionUniversity of Zagreb School of Medicine
dc.contributor.institutionIWK Health Centre and Dalhousie University
dc.contributor.institutionHacettepe University
dc.contributor.institutionNorthwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.contributor.institutionNational and Kapodistian University of Athens
dc.contributor.institutionUniversity Teknologi MARA
dc.contributor.institutionInstituto Mexicano del Seguro Social
dc.contributor.institutionUniversity of Washington and Seattle Children's Hospital
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionAmsterdam University Medical Center
dc.contributor.institutionRed Cross War Memorial Children's Hospital and University of Cape Town
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionHospital de la Beneficencia Española
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionNational Medical Center La Raza
dc.contributor.institutionAristotle University of Thessaloniki
dc.contributor.institutionKing Faisal Specialist Hospital and Research Center and Alfaisal University
dc.contributor.institutionUniversity of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center
dc.date.accessioned2022-04-28T19:49:00Z
dc.date.available2022-04-28T19:49:00Z
dc.date.issued2022-02-01
dc.description.abstractObjective: To develop a standardized steroid dosing regimen (SSR) for physicians treating childhood-onset systemic lupus erythematosus (SLE) complicated by lupus nephritis (LN), using consensus formation methodology. Methods: Parameters influencing corticosteroid (CS) dosing were identified (step 1). Data from children with proliferative LN were used to generate patient profiles (step 2). Physicians rated changes in renal and extrarenal childhood-onset SLE activity between 2 consecutive visits and proposed CS dosing (step 3). The SSR was developed using patient profile ratings (step 4), with refinements achieved in a physician focus group (step 5). A second type of patient profile describing the course of childhood-onset SLE for ≥4 months since kidney biopsy was rated to validate the SSR-recommended oral and intravenous (IV) CS dosages (step 6). Patient profile adjudication was based on majority ratings for both renal and extrarenal disease courses, and consensus level was set at 80%. Results: Degree of proteinuria, estimated glomerular filtration rate, changes in renal and extrarenal disease activity, and time since kidney biopsy influenced CS dosing (steps 1 and 2). Considering these parameters in 5,056 patient profile ratings from 103 raters, and renal and extrarenal course definitions, CS dosing rules of the SSR were developed (steps 3–5). Validation of the SSR for up to 6 months post–kidney biopsy was achieved with 1,838 patient profile ratings from 60 raters who achieved consensus for oral and IV CS dosage in accordance with the SSR (step 6). Conclusion: The SSR represents an international consensus on CS dosing for use in patients with childhood-onset SLE and proliferative LN. The SSR is anticipated to be used for clinical care and to standardize CS dosage during clinical trials.en
dc.description.affiliationUniversity of Cincinnati College of Medicine
dc.description.affiliationBaylor College of Medicine
dc.description.affiliationThe Hospital for Sick Children and The University of Toronto
dc.description.affiliationEmory University and Children's Healthcare of Atlanta
dc.description.affiliationSanjay Gandhi Postgraduate Institute of Medical Sciences
dc.description.affiliationMedical University of South Carolina
dc.description.affiliationKK Women's and Children's Hospital
dc.description.affiliationCincinnati Children's Hospital Medical Center
dc.description.affiliationHospital for Special Surgery
dc.description.affiliationAlbert Einstein College of Medicine
dc.description.affiliationSRCC Children's Hospital
dc.description.affiliationCapital Medical University and National Center for Children's Health
dc.description.affiliationUniversidade Federal do Rio de Janeiro
dc.description.affiliationNationwide Children's Hospital
dc.description.affiliationUniversity College London
dc.description.affiliationCerrahpasa Medical School Istanbul University-Cerrahpasa
dc.description.affiliationUniversity of Zagreb School of Medicine
dc.description.affiliationIWK Health Centre and Dalhousie University
dc.description.affiliationHacettepe University
dc.description.affiliationNorthwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago
dc.description.affiliationUniversity of Campinas
dc.description.affiliationHospital das Clínicas da Universidade Federal de Pernambuco
dc.description.affiliationNational and Kapodistian University of Athens
dc.description.affiliationUniversity Teknologi MARA
dc.description.affiliationInstituto Mexicano del Seguro Social
dc.description.affiliationUniversity of Washington and Seattle Children's Hospital
dc.description.affiliationSão Paulo State University
dc.description.affiliationAmsterdam University Medical Center
dc.description.affiliationRed Cross War Memorial Children's Hospital and University of Cape Town
dc.description.affiliationUniversidade de São Paulo
dc.description.affiliationHospital de la Beneficencia Española
dc.description.affiliationUniversidade Federal de São Paulo
dc.description.affiliationNational Medical Center La Raza
dc.description.affiliationAristotle University of Thessaloniki
dc.description.affiliationKing Faisal Specialist Hospital and Research Center and Alfaisal University
dc.description.affiliationUniversity of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center
dc.description.affiliationUnespSão Paulo State University
dc.description.sponsorshipArthritis Foundation
dc.description.sponsorshipInstitute of Clinical and Translational Sciences
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipNational Institute of Arthritis and Musculoskeletal and Skin Diseases
dc.description.sponsorshipNational Institute of Diabetes and Digestive and Kidney Diseases
dc.description.sponsorshipNational Center for Advancing Translational Sciences
dc.description.sponsorshipIdCNPq: 303422/2015-7
dc.description.sponsorshipIdFAPESP: FAPESP 2015/03756-4
dc.description.sponsorshipIdNational Institute of Arthritis and Musculoskeletal and Skin Diseases: P30-AR-076316
dc.description.sponsorshipIdNational Institute of Diabetes and Digestive and Kidney Diseases: P50-DK-096418
dc.description.sponsorshipIdNational Institute of Arthritis and Musculoskeletal and Skin Diseases: R34-AR-071651
dc.description.sponsorshipIdNational Center for Advancing Translational Sciences: T32-AR-050958
dc.format.extent263-273
dc.identifierhttp://dx.doi.org/10.1002/art.41930
dc.identifier.citationArthritis and Rheumatology, v. 74, n. 2, p. 263-273, 2022.
dc.identifier.doi10.1002/art.41930
dc.identifier.issn2326-5205
dc.identifier.issn2326-5191
dc.identifier.scopus2-s2.0-85122264560
dc.identifier.urihttp://hdl.handle.net/11449/223171
dc.language.isoeng
dc.relation.ispartofArthritis and Rheumatology
dc.sourceScopus
dc.titleInternational Consensus for the Dosing of Corticosteroids in Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritisen
dc.typeArtigo

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