Hypertension modifies OPG, RANK, and RANKL expression during the dental socket bone healing process in spontaneously hypertensive rats
dc.contributor.author | Manrique, Natalia [UNESP] | |
dc.contributor.author | Silva Pereira, Cassiano Costa [UNESP] | |
dc.contributor.author | Luvizuto, Eloa Rodrigues [UNESP] | |
dc.contributor.author | Rodriguez Sanchez, Maria Del Pilar [UNESP] | |
dc.contributor.author | Okamoto, Tetuo | |
dc.contributor.author | Okamoto, Roberta [UNESP] | |
dc.contributor.author | Sumida, Doris H. [UNESP] | |
dc.contributor.author | Antoniali, Cristina [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.date.accessioned | 2015-10-21T13:10:31Z | |
dc.date.available | 2015-10-21T13:10:31Z | |
dc.date.issued | 2015-07-01 | |
dc.description.abstract | Objective The aim of this study was to evaluate the dental socket bone healing process by histomorphometric and immunohistochemical analysis of osteoprotegerin (OPG), receptor activator of nuclear factor-kappa beta (RANK), and receptor activator of nuclear factor-kappa beta ligand (RANKL) proteins in spontaneously hypertensive rats (SHR).Materials and methods Under general anesthesia, 25 Wistar rats and 25 SHRs underwent upper right incisor extraction. Rats were euthanized after 7, 14, 21, 28, or 42 days of dental extractions. Histomorphometric and immunohistochemical analyses of OPG, RANK, and RANKL proteins were performed.Results Histomorphometric results showed decreased bone healing and reduced bone trabecular thickness in SHRs. Immunohistochemical reactions showed intense RANKL and RANK immunolabeling at 14 and 28 postoperative days and mild OPG immunolabeling at 7, 14, and 21 days after surgery in SHRs.Conclusion The results of this study show that RANK, RANKL, and OPG immunolabeling was altered in SHRs, and these results are associated with bone healing delay and decreased trabecular thickness in SHRs.Clinical relevance Hypertension alters the expression of RANK, RANKL, and OPG and delays the socket bone healing process. These alterations could influence some dental procedures such as orthodontic treatment and implant placement. | en |
dc.description.affiliation | Sacred Heart Univ USC, Grad Res Dept, Bauru, SP, Brazil | |
dc.description.affiliationUnesp | Universidade Estadual Paulista, Sch Dent Aracatuba, Dept Pediat &Social Dent, BR-16015050 Aracatuba, SP, Brazil | |
dc.description.affiliationUnesp | UNESP Univ Estadual Paulista, Sch Dent Aracatuba, Dept Surg, BR-16015050 Aracatuba, SP, Brazil | |
dc.description.affiliationUnesp | UNESP Univ Estadual Paulista, Sch Dent Aracatuba, Integrated Clin, BR-16015050 Aracatuba, SP, Brazil | |
dc.description.affiliationUnesp | UNESP Univ Estadual Paulista, Sch Dent Aracatuba, Dept Basic Sci, BR-16015050 Aracatuba, SP, Brazil | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorship | UNESP Research Internationalization Program (PROINTER/PROPe-UNESP) | |
dc.description.sponsorshipId | FAPESP: 2008/01893-0 | |
dc.format.extent | 1319-1327 | |
dc.identifier | http://link.springer.com/article/10.1007%2Fs00784-014-1369-0 | |
dc.identifier.citation | Clinical Oral Investigations. Heidelberg: Springer Heidelberg, v. 19, n. 6, p. 1319-1327, 2015. | |
dc.identifier.doi | 10.1007/s00784-014-1369-0 | |
dc.identifier.issn | 1432-6981 | |
dc.identifier.lattes | 0169955363968097 | |
dc.identifier.lattes | 1566928219828056 | |
dc.identifier.uri | http://hdl.handle.net/11449/128511 | |
dc.identifier.wos | WOS:000356774100016 | |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.relation.ispartof | Clinical Oral Investigations | |
dc.relation.ispartofjcr | 2.386 | |
dc.relation.ispartofsjr | 0,986 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Extraction socket healing | en |
dc.subject | Histomorphometry | en |
dc.subject | Spontaneously hypertensive rats | en |
dc.subject | OPG | en |
dc.subject | RANK | en |
dc.subject | RANKL | en |
dc.title | Hypertension modifies OPG, RANK, and RANKL expression during the dental socket bone healing process in spontaneously hypertensive rats | en |
dc.type | Artigo | |
dcterms.license | http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0 | |
dcterms.rightsHolder | Springer | |
unesp.author.lattes | 0169955363968097 | |
unesp.author.lattes | 1566928219828056 | |
unesp.author.orcid | 0000-0002-4169-2918[4] | |
unesp.author.orcid | 0000-0002-0315-6161[8] | |
unesp.author.orcid | 0000-0002-6773-6966[6] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba | pt |
unesp.department | Cirurgia e Clínica Integrada - FOA | pt |
unesp.department | Ciências Básicas - FOA | pt |
unesp.department | Odontologia Infantil e Social - FOA | pt |