The Plastic Glial-Synaptic Dynamics within the Neuropil: A Self-Organizing System Composed of Polyelectrolytes in Phase Transition

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dc.contributor.authorDe Lima, Vera Maura Fernandes
dc.contributor.authorPereira, Alfredo [UNESP]
dc.contributor.institutionIPEN-CNEN/SP
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:50:09Z
dc.date.available2018-12-11T16:50:09Z
dc.date.issued2016-01-01
dc.description.abstractSeveral explanations have been proposed to account for the mechanisms of neuroglial interactions involved in neural plasticity. We review experimental results addressing plastic nonlinear interactions between glial membranes and synaptic terminals. These results indicate the necessity of elaborating on a model based on the dynamics of hydroionic waves within the neuropil. These waves have been detected in a small scale experimental model of the central nervous system, the in vitro retina. We suggest that the brain, as the heart and kidney, is a system for which the state of water is functional. The use of nonlinear thermodynamics supports experiments at convenient biological spatiotemporal scales, while an understanding of the properties of ions and their interactions with water requires explanations based on quantum theories. In our approach, neural plasticity is seen as part of a larger process that encompasses higher brain functions; in this regard, hydroionic waves within the neuropil are considered to carry both physiological and cognitive functions.en
dc.description.affiliationCentro de Biotecnologia IPEN-CNEN/SP, Avenida Prof. Lineu Prestes 2242
dc.description.affiliationInstitute of Biosciences of Botucatu São Paulo State University (UNESP), Campus Rubião Jr.
dc.description.affiliationUnespInstitute of Biosciences of Botucatu São Paulo State University (UNESP), Campus Rubião Jr.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.identifierhttp://dx.doi.org/10.1155/2016/7192427
dc.identifier.citationNeural Plasticity, v. 2016.
dc.identifier.doi10.1155/2016/7192427
dc.identifier.file2-s2.0-85031978851.pdf
dc.identifier.issn1687-5443
dc.identifier.issn2090-5904
dc.identifier.scopus2-s2.0-85031978851
dc.identifier.urihttp://hdl.handle.net/11449/170296
dc.language.isoeng
dc.relation.ispartofNeural Plasticity
dc.relation.ispartofsjr1,348
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleThe Plastic Glial-Synaptic Dynamics within the Neuropil: A Self-Organizing System Composed of Polyelectrolytes in Phase Transitionen
dc.typeResenha

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