Screening of Formulation Variables for the Preparation of Poly(epsilon-caprolactone) Nanocapsules Containing the Local Anesthetic Benzocaine

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dc.contributor.authorMoraes, Carolina Morales
dc.contributor.authorde Matos, Angelica Prado
dc.contributor.authorGrillo, Renato [UNESP]
dc.contributor.authorde Melo, Nathalie F. S. [UNESP]
dc.contributor.authorde Paula, Eneida
dc.contributor.authorDias Filho, Newton Luiz [UNESP]
dc.contributor.authorRosa, Andre Henrique [UNESP]
dc.contributor.authorFraceto, Leonardo Fernandes [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:29:52Z
dc.date.available2014-05-20T13:29:52Z
dc.date.issued2011-03-01
dc.description.abstractIn this work we describe the screening of four parameters in the preparation, by nanoprecipitation, of poly(epsilon-caprolactone) nanocapsules, used as a drug carrier system for the local anesthetic, benzocaine. A 2(4-1) factorial experimental design was used to study the influence of four different independent variables (polymer, oily phase, Span 60 and Tween 80) on nanocapsule characteristics (size, polydispersion index, zeta potential) and drug loading capability. Best results were obtained using an aqueous formulation comprising 100 mg of polymer, 200 mg of oily phase, 40 mg of Span 60 and 60 mg of Tween 80 in a final volume of 10 mL which produced a colloidal system with particle size of 188 nm, zeta potential -32 mV, polydispersion index 0.07, and benzocaine association efficiency > 87%. These findings open the way for future clinical studies using such formulations.en
dc.description.affiliationState Univ Campinas UNICAMP, Dept Biochem, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUnesp Univ Estadual Paulista, Dept Environm Engn, BR-18087180 São Paulo, Brazil
dc.description.affiliationUnesp Univ Estadual Paulista, Dept Phys & Chem, BR-15385000 São Paulo, Brazil
dc.description.affiliationUnespUnesp Univ Estadual Paulista, Dept Environm Engn, BR-18087180 São Paulo, Brazil
dc.description.affiliationUnespUnesp Univ Estadual Paulista, Dept Phys & Chem, BR-15385000 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipIdFAPESP: 06-00121-9
dc.description.sponsorshipIdFAPESP: 07/00127-0
dc.format.extent2450-2457
dc.identifierhttp://dx.doi.org/10.1166/jnn.2011.3547
dc.identifier.citationJournal of Nanoscience and Nanotechnology. Stevenson Ranch: Amer Scientific Publishers, v. 11, n. 3, p. 2450-2457, 2011.
dc.identifier.doi10.1166/jnn.2011.3547
dc.identifier.issn1533-4880
dc.identifier.lattes1509480515046572
dc.identifier.lattes2188736885721242
dc.identifier.orcid0000-0002-2042-018X
dc.identifier.orcid0000-0002-0284-5782
dc.identifier.urihttp://hdl.handle.net/11449/10130
dc.identifier.wosWOS:000288102300090
dc.language.isoeng
dc.publisherAmer Scientific Publishers
dc.relation.ispartofJournal of Nanoscience and Nanotechnology
dc.relation.ispartofjcr1.354
dc.relation.ispartofsjr0,326
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectExperimental Designen
dc.subject2(4-1) Factorial Experimentalen
dc.subjectNanoparticlesen
dc.subjectPolymeric Nanocapsulesen
dc.subjectLocal Anestheticen
dc.titleScreening of Formulation Variables for the Preparation of Poly(epsilon-caprolactone) Nanocapsules Containing the Local Anesthetic Benzocaineen
dc.typeArtigo
dcterms.licensehttp://www.aspbs.com/jnn/JNN%20Copyright%20Transfer%20Form.pdf
dcterms.rightsHolderAmer Scientific Publishers
unesp.author.lattes1509480515046572
unesp.author.lattes5228846314663888[7]
unesp.author.lattes2188736885721242[3]
unesp.author.orcid0000-0002-2042-018X[7]
unesp.author.orcid0000-0002-0284-5782[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, Sorocabapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Engenharia, Ilha Solteirapt
unesp.departmentFísica e Química - FEISpt

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Ilha Solteira - FEIS - Faculdade de Engenharia
Artigos - Engenharia Ambiental - Sorocaba