COVID-19 (SARS-CoV-2) infection and thrombotic conditions: A systematic review and meta-analysis

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dc.contributor.authorGabbai-Armelin, Paulo Roberto [UNESP]
dc.contributor.authorde Oliveira, Analú Barros [UNESP]
dc.contributor.authorFerrisse, Túlio Morandin [UNESP]
dc.contributor.authorSales, Luciana Solera [UNESP]
dc.contributor.authorBarbosa, Elis Rodrigues Oliveira [UNESP]
dc.contributor.authorMiranda, Marina Lins [UNESP]
dc.contributor.authorSalomão, Karina Borges [UNESP]
dc.contributor.authorBrighenti, Fernanda Lourenção [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-06-25T10:28:20Z
dc.date.available2021-06-25T10:28:20Z
dc.date.issued2021-01-01
dc.description.abstractBackground: COVID-19 is an infectious disease caused by SARS-CoV-2 associated with haematological manifestations (thrombolytic events). Aims: Considering the high prevalence of the thrombotic scenarios associated with COVID-19, the aim of this study was to perform a systematic review of the available literature, concerning the relation of COVID-19 and the thrombotic events, and identify prognostic factors for these events. Materials & Methods: PubMed, Web of Science and Scopus databases were searched. Independent reviewers conducted all flow diagram steps. For qualitative analysis, Oxford level of evidence and Newcastle-Ottawa scale were used in the eligible articles. For the prognostic factors, a meta-analysis was conducted to age, number of neutrophils and platelets, and levels of ferritin, C-reactive protein, lactate dehydrogenase and D-dimer. Publication bias was accessed by funnel plot and by trim-and-fill test. Trim-and-fill test was also applied to evaluate meta-analysis bias. Results: Twenty articles were included in the qualitative analysis, and 6 articles were included in the meta-analysis. Case-control studies showed bias related to exposure, and the main bias in cohort studies were related to selection and outcome. All articles received score 4 for the level of evidence. Hypertension and diabetes were the comorbidities more frequently associated with thrombolytic events. Significant results were found regarding D-dimer (P <.0001) and age (P =.0202) for thrombotic events in patients diagnosed with COVID-19. Conclusion: Patients older than 60 years, with hypertension, diabetes and D-Dimer values above 3.17 µg/mL, can be considered prognostic factors for developing thrombotic events due to COVID-19.en
dc.description.affiliationSchool of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespSchool of Dentistry São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.1111/eci.13559
dc.identifier.citationEuropean Journal of Clinical Investigation.
dc.identifier.doi10.1111/eci.13559
dc.identifier.issn1365-2362
dc.identifier.issn0014-2972
dc.identifier.scopus2-s2.0-85104330871
dc.identifier.urihttp://hdl.handle.net/11449/206207
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Clinical Investigation
dc.sourceScopus
dc.subjectCOVID-19
dc.subjectD-dimer
dc.subjectmeta-analysis
dc.subjectprognostic factors
dc.subjectSARS-CoV-2
dc.subjectsystematic review
dc.subjectthrombosis
dc.titleCOVID-19 (SARS-CoV-2) infection and thrombotic conditions: A systematic review and meta-analysisen
dc.typeResenha
unesp.author.orcid0000-0003-4802-0062[1]
unesp.author.orcid0000-0002-7177-4519[2]
unesp.author.orcid0000-0002-9933-2819[3]
unesp.author.orcid0000-0002-4470-5171[8]

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