Effectiveness of low-dose diuretics for blood pressure reduction to optimal values in prehypertension: A randomizedclinical trial
dc.contributor.author | Fuchs, Flávio D. | |
dc.contributor.author | Fuchs, Sandra C. | |
dc.contributor.author | Poli-de-Figueiredo, Carlos E. | |
dc.contributor.author | Figueiredo Neto, José A. | |
dc.contributor.author | Scala, Luiz César N. | |
dc.contributor.author | Vilela-Martin, José F. | |
dc.contributor.author | Moreira, Leila B. | |
dc.contributor.author | Chaves, Hilton | |
dc.contributor.author | Gomes, Marco Mota | |
dc.contributor.author | De Sousa, Marcos R. | |
dc.contributor.author | E Silva, Ricardo Pereira | |
dc.contributor.author | Castro, Iran | |
dc.contributor.author | Cesarino, Evandro José | |
dc.contributor.author | Sousa, Ana Luiza Lima | |
dc.contributor.author | Alves, João Guilherme | |
dc.contributor.author | Steffens, André Avelino | |
dc.contributor.author | Brandão, Andréa Araujo | |
dc.contributor.author | Bortolotto, Luiz Aparecido | |
dc.contributor.author | Neto, Abrahão Afiune | |
dc.contributor.author | Nóbrega, Antônio C. | |
dc.contributor.author | Franco, Roberto Silva [UNESP] | |
dc.contributor.author | Filho, Dario C. Sobral | |
dc.contributor.author | Nobre, Fernando | |
dc.contributor.author | Schlatter, Rosane | |
dc.contributor.author | Gus, Miguel | |
dc.contributor.author | De David, Caroline Nespolo | |
dc.contributor.author | Rafaelli, Leticia | |
dc.contributor.author | Sesin, Guilhermo Prates | |
dc.contributor.author | Berwanger, Otávio | |
dc.contributor.author | Whelton, Paul K. | |
dc.contributor.institution | Universidade Federal do Rio Grande do Sul | |
dc.contributor.institution | PUCRS | |
dc.contributor.institution | Universidade Federal do Maranhão | |
dc.contributor.institution | Universidade Federal de Mato Grosso | |
dc.contributor.institution | Hospital de Base | |
dc.contributor.institution | Universidade Federal de Pernambuco (UFPE) | |
dc.contributor.institution | Hospital do Coração | |
dc.contributor.institution | Universidade Federal de Minas Gerais (UFMG) | |
dc.contributor.institution | Universidade Federal do Ceará | |
dc.contributor.institution | Instituto de Cardiologia | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Universidade Federal de Goiás (UFG) | |
dc.contributor.institution | Instituto de Medicina Integral Prof. Fernando Figueira | |
dc.contributor.institution | Universidade Federal de Pelotas | |
dc.contributor.institution | Universidade do Estado do Rio de Janeiro (UERJ) | |
dc.contributor.institution | Hospital do Coração Anis Rassi | |
dc.contributor.institution | Universidade Federal Fluminense (UFF) | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | Hospital Universitário PROCAPE | |
dc.contributor.institution | Tulane University School of Public Health and Tropical Medicine | |
dc.contributor.institution | Research Institute HC or Hospital do Coração | |
dc.date.accessioned | 2022-04-28T19:09:40Z | |
dc.date.available | 2022-04-28T19:09:40Z | |
dc.date.issued | 2018-04-01 | |
dc.description.abstract | Background: To determine the effectiveness of low-dose diuretic therapy to achieve an optimal level of blood pressure (BP) in adults with prehypertension. Methods: The PREVER-prevention trial was a randomized, parallel, double-blinded, placebo-controlled trial, with 18 months of follow-up, conducted at 21 academic medical centers in Brazil. Of 1772 individuals evaluated for eligibility, 730 volunteers with prehypertension who were aged 30-70 years, and who did not reach optimal blood pressure after 3 months of lifestyle intervention, were randomized to a fixed association of chlorthalidone 12.5mg and amiloride 2.5mg or placebo once a day. The main outcomes were the percentage of participants who achieved an optimal level of BP. Results: A total of 372 participants were randomly allocated to diuretics and 358 to placebo. After 18 months of treatment, optimal BP was noted in 25.6% of the diuretic group and 19.3% in the placebo group (P<0.05). The mean net reduction in SBP and DBP for the diuretic group compared with placebo was 2.8mmHg (95% CI 1.1 to 4.5) and 1.1mmHg (95% CI -0.09 to 2.4), respectively. Most participants in the active treatment group (74.5%) and in the placebo group (80.7%) continued to have BP in the prehypertension range or progressed to hypertension. Conclusion: Low-dose diuretic therapy increased the probability of individuals with prehypertension to achieve optimal BP but most of those treated continued to have a BP in the prehypertension range or progressed to having overt hypertension. | en |
dc.description.affiliation | Serviço de Cardiologia Hospital de Clínicas de Porto Alegre Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2350 | |
dc.description.affiliation | Faculdade deMedicina Hospital São Lucas PUCRS | |
dc.description.affiliation | Hospital Universitário Universidade Federal do Maranhão | |
dc.description.affiliation | Hospital Universitário Júlio Müller Universidade Federal de Mato Grosso | |
dc.description.affiliation | Faculdade de Medicina de São José do Rio Preto Hospital de Base | |
dc.description.affiliation | Universidade Federal de Pernambuco | |
dc.description.affiliation | Hospital do Coração | |
dc.description.affiliation | Hospital das Clínicas da Universidade Federal de Minas Gerais | |
dc.description.affiliation | Hospital Universitário Walter Cantídio Universidade Federal do Ceará | |
dc.description.affiliation | Instituto de Cardiologia | |
dc.description.affiliation | Faculdade de Ciências Farmacêuticas USP Ribeirão Preto | |
dc.description.affiliation | Hospital das Clínicas da Universidade Federal de Goiás | |
dc.description.affiliation | Instituto de Medicina Integral Prof. Fernando Figueira | |
dc.description.affiliation | Universidade Federal de Pelotas | |
dc.description.affiliation | Universidade do Estado do Rio de Janeiro | |
dc.description.affiliation | Instituto do Coração Faculdade deMedicina Universidade de São Paulo | |
dc.description.affiliation | Hospital do Coração Anis Rassi | |
dc.description.affiliation | Hospital Universitário Antônio Pedro Universidade Federal Fluminense | |
dc.description.affiliation | Faculdade de Medicina de Botucatu | |
dc.description.affiliation | Hospital Universitário PROCAPE | |
dc.description.affiliation | Faculdade deMedicina de Ribeirão Preto USP Ribeirão Preto | |
dc.description.affiliation | Department of Epidemiology Tulane University School of Public Health and Tropical Medicine | |
dc.description.affiliation | Research Institute HC or Hospital do Coração | |
dc.description.affiliationUnesp | Faculdade de Medicina de Botucatu | |
dc.description.sponsorship | Ministry of Science and Technology | |
dc.format.extent | 933-938 | |
dc.identifier | http://dx.doi.org/10.1097/HJH.0000000000001624 | |
dc.identifier.citation | Journal of Hypertension, v. 36, n. 4, p. 933-938, 2018. | |
dc.identifier.doi | 10.1097/HJH.0000000000001624 | |
dc.identifier.issn | 1473-5598 | |
dc.identifier.issn | 0263-6352 | |
dc.identifier.scopus | 2-s2.0-85049680825 | |
dc.identifier.uri | http://hdl.handle.net/11449/221112 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Hypertension | |
dc.source | Scopus | |
dc.subject | Chlorthalidone and amiloride | |
dc.subject | Clinical trials | |
dc.subject | Hypertension | |
dc.subject | Optimal blood pressure | |
dc.subject | Prehypertension | |
dc.title | Effectiveness of low-dose diuretics for blood pressure reduction to optimal values in prehypertension: A randomizedclinical trial | en |
dc.type | Artigo |