Chitosan and collagen composite for potential application as bone substitute

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dc.contributor.authorde Castro, Karine Cappuccio
dc.contributor.authorvan de Graaf, Guilherme Maia Mulder
dc.contributor.authorMarques, Rodrigo Fernando Costa [UNESP]
dc.contributor.authorCampos, Maria Gabriela Nogueira
dc.contributor.institutionFederal University of Alfenas
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Central Florida
dc.date.accessioned2022-04-30T18:37:00Z
dc.date.available2022-04-30T18:37:00Z
dc.date.issued2019-03-01
dc.description.abstractPurpose: Biopolymers, such as chitosan and collagen, have excellent biocompatibility and can be used for bone remodeling. Chitosan and collagen can be crosslinked by glutaraldehyde. The aim of this study was to formulate a chitosan, collagen, and calcium phosphate-based device for potential application as bone substitutes. Methods: The device was synthesized, molded, dried, and characterized. Results: By FTIR, it was possible to observe a characteristic peak relating to the crosslinking of chitosan and collagen. The images of SEM and BET/BJH results showed the presence of apparent and interconnected pores. TG-DSC have shown two temperature ranges for weight loss. Mechanical tests provided an elastic modulus equal to 239.25 ± 78.37 MPa and maximum tension of 4.33 ± 0.95 MPa, which are comparable to some commercial bone substitutes and other similar synthetic devices. Conclusion: The synthesized device showed interconnected pores and surficial porosity, besides thermal stability at physiological temperature, and mechanical properties comparable to spongy bones.en
dc.description.affiliationInstitute of Science and Technology Federal University of Alfenas, Rodovia José Aurélio Vilela, 11999, Cidade Universitária
dc.description.affiliationSchool of Chemical Engineering State University of Campinas
dc.description.affiliationFaculty of Animal Science and Veterinary Medicine University of São Paulo
dc.description.affiliationInstitute of Chemistry São Paulo State University “Julio de Mesquita Filho”
dc.description.affiliationNanoScience Technology Center University of Central Florida
dc.description.affiliationUnespInstitute of Chemistry São Paulo State University “Julio de Mesquita Filho”
dc.format.extent65-70
dc.identifierhttp://dx.doi.org/10.1007/s42600-019-00002-5
dc.identifier.citationResearch on Biomedical Engineering, v. 35, n. 1, p. 65-70, 2019.
dc.identifier.doi10.1007/s42600-019-00002-5
dc.identifier.issn2446-4740
dc.identifier.issn2446-4732
dc.identifier.scopus2-s2.0-85066948672
dc.identifier.urihttp://hdl.handle.net/11449/232884
dc.language.isoeng
dc.relation.ispartofResearch on Biomedical Engineering
dc.sourceScopus
dc.subjectBone tissue
dc.subjectCalcium phosphate
dc.subjectChitosan
dc.subjectCollagen
dc.subjectRegeneration
dc.titleChitosan and collagen composite for potential application as bone substituteen
dc.typeArtigo

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Artigos - Físico Química - IQ