Melatonin and ethanol intake exert opposite effects on circulating estradiol and progesterone and differentially regulate sex steroid receptors in the ovaries, oviducts, and uteri of adult rats

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dc.contributor.authorChuffa, Luiz Gustavo A. [UNESP]
dc.contributor.authorSeiva, Fábio R.F. [UNESP]
dc.contributor.authorFávaro, Wagner José [UNESP]
dc.contributor.authorAmorim, João Paulo A. [UNESP]
dc.contributor.authorTeixeira, Giovana R. [UNESP]
dc.contributor.authorMendes, Leonardo O. [UNESP]
dc.contributor.authorFioruci-Fontanelli, Beatriz A. [UNESP]
dc.contributor.authorPinheiro, Patricia Fernanda F. [UNESP]
dc.contributor.authorMartinez, Marcelo
dc.contributor.authorMartinez, Francisco Eduardo [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2014-05-27T11:30:05Z
dc.date.available2014-05-27T11:30:05Z
dc.date.issued2013-08-01
dc.description.abstractChronic ethanol intake is associated with sex hormone disturbances, and it is well known that melatonin plays a key role in regulating several reproductive processes. We report the effects of ethanol intake and melatonin treatment (at doses of 100. μg/100. g. BW/day) on sex hormones and steroid receptors in the ovaries, oviducts and uteri of ethanol-preferring rats. After 150 days of treatment, animals were euthanized, and tissue samples were harvested to evaluate androgen, estrogen, progesterone and melatonin receptor subunits (AR, ER-α and ER-β, PRA, PRB and MT1R, respectively). Melatonin decreased estradiol (E2) and increased progesterone (P4) and 6-sulfatoxymelatonin (6-STM), while an ethanol-melatonin combination reduced both P4 and E2. Ovarian AR was not influenced by either treatment, and oviduct AR was reduced after ethanol-melatonin combination. Oviduct ER-α, ER-β and uterine ER-β were down-regulated by either ethanol or melatonin. Conversely, ovarian PRA and PRB were positively regulated by ethanol and ethanol-melatonin combination, whereas PRA was down-regulated in the uterus and oviduct after ethanol consumption. MT1R was increased in ovaries and uteri of melatonin-treated rats. Ethanol and melatonin exert opposite effects on E2 and P4, and they differentially regulate the expression of sex steroid receptors in female reproductive tissues. © 2013 Elsevier Inc.en
dc.description.affiliationGraduação em Biologia Celular e Estrutural Instituto de Biologia Universidade Estadual de Campinas-UNICAMP, Campinas 13083-863, SP
dc.description.affiliationDepartamento de Anatomia Instituto de Biociências UNESP-Universidade Estadual Paulista, Botucatu 18618-000, SP
dc.description.affiliationDepartamento de Química e Bioquímica Instituto de Biociências UNESP-Universidade Estadual Paulista, Botucatu 18618-000, SP
dc.description.affiliationDepartamento de Morfologia e Patologia UFSCar-Universidade Federal de São Carlos, São Carlos 13565-905, SP
dc.description.affiliationUnespDepartamento de Anatomia Instituto de Biociências UNESP-Universidade Estadual Paulista, Botucatu 18618-000, SP
dc.description.affiliationUnespDepartamento de Química e Bioquímica Instituto de Biociências UNESP-Universidade Estadual Paulista, Botucatu 18618-000, SP
dc.format.extent40-49
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2013.04.001
dc.identifier.citationReproductive Toxicology, v. 39, p. 40-49.
dc.identifier.doi10.1016/j.reprotox.2013.04.001
dc.identifier.issn0890-6238
dc.identifier.issn1873-1708
dc.identifier.lattes1739564105219382
dc.identifier.lattes5760560970751598
dc.identifier.orcid0000-0003-1452-5708
dc.identifier.scopus2-s2.0-84877322452
dc.identifier.urihttp://hdl.handle.net/11449/76142
dc.identifier.wosWOS:000320678700006
dc.language.isoeng
dc.relation.ispartofReproductive Toxicology
dc.relation.ispartofjcr2.580
dc.relation.ispartofsjr0,846
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectEthanol
dc.subjectFemale reproductive tissue
dc.subjectMelatonin
dc.subjectSex hormone
dc.subjectSex steroid receptor
dc.subject6 hydroxymelatonin o sulfate
dc.subjectalcohol
dc.subjectandrogen receptor
dc.subjectbeta actin
dc.subjectdaidzein
dc.subjectestradiol
dc.subjectestrogen receptor alpha
dc.subjectestrogen receptor beta
dc.subjectgenistein
dc.subjectmelatonin
dc.subjectmelatonin 1 receptor
dc.subjectprogesterone
dc.subjectprogesterone receptor A
dc.subjectprogesterone receptor B
dc.subjectalcohol consumption
dc.subjectalcoholism
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectcontrolled study
dc.subjectdietary intake
dc.subjectenzyme activity
dc.subjectenzyme regulation
dc.subjectfemale
dc.subjectnonhuman
dc.subjectnutritional assessment
dc.subjectovary
dc.subjectoviduct
dc.subjectprotein expression
dc.subjectprotein function
dc.subjectrat
dc.subjectuterus
dc.titleMelatonin and ethanol intake exert opposite effects on circulating estradiol and progesterone and differentially regulate sex steroid receptors in the ovaries, oviducts, and uteri of adult ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes1739564105219382
unesp.author.lattes5760560970751598[8]
unesp.author.orcid0000-0001-5830-8938[1]
unesp.author.orcid0000-0002-9317-344X[10]
unesp.author.orcid0000-0002-7461-8773[2]
unesp.author.orcid0000-0002-0199-3396[1]
unesp.author.orcid0000-0002-0044-2939[5]
unesp.author.orcid0000-0003-1452-5708[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Anatomia - IBB
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