Antimycobacterial activity of lichen substances

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dc.contributor.authorHonda, N. K.
dc.contributor.authorPavan, Fernando Rogério [UNESP]
dc.contributor.authorCoelho, R. G.
dc.contributor.authorde Andrade Leite, S. R. [UNESP]
dc.contributor.authorMicheletti, A. C.
dc.contributor.authorLopes, T. I. B.
dc.contributor.authorMisutsu, M. Y.
dc.contributor.authorBeatriz, A.
dc.contributor.authorBrum, R. L.
dc.contributor.authorLeite, Clarice Queico Fujimura [UNESP]
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:12Z
dc.date.available2014-05-20T13:24:12Z
dc.date.issued2010-04-01
dc.description.abstractWe describe here the extraction and identification of several classes of phenolic compounds from the lichens Parmotrema dilatatum (Vain.) Hale, Parmotrema tinctorum (Nyl.) Hale, Pseudoparmelia sphaerospora (Nyl.) Hale and Usnea subcavata (Motyka) and determined their anti-tubercular activity. The depsides (atranorin, diffractaic and lecanoric acids), depsidones (protocetraric, salazinic, hypostictic and norstictic acids), xanthones (lichexanthone and secalonic acid), and usnic acid, as well seven orsellinic acid esters, five salazinic acid 8',9'-O-alkyl derivatives and four lichexanthone derivatives, were evaluated for their activity against Mycobacterium tuberculosis. Diffractaic acid was the most active compound (MIC value 15.6 mu g/ml, 41.6 mu M), followed by norstictic acid (MIC value 62.5 mu g/ml, 168 mu M) and usnic acid (MIC value 62.5 mu g/ml, 182 mu M). Hypostictic acid (MIC value 94.0 mu g/ml, 251 mu M) and protocetraric acid (MIC value 125 mu g/ml, 334 mu M) showed moderate inhibitory activity. The other compounds showed lower inhibitory activity on the growth of M. tuberculosis, varying from MIC values of 250 to 1370 mu M. (C) 2009 Elsevier GmbH. All rights reserved.en
dc.description.affiliationUniversidade Federal de Mato Grosso do Sul (UFMS), Dept Quim, BR-79070900 Campo Grande, MS, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Quim, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Quim, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT)
dc.description.sponsorshipCPq-PROPP-UFMS
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCientific Iniciation-PET
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent328-332
dc.identifierhttp://dx.doi.org/10.1016/j.phymed.2009.07.018
dc.identifier.citationPhytomedicine. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 17, n. 5, p. 328-332, 2010.
dc.identifier.doi10.1016/j.phymed.2009.07.018
dc.identifier.issn0944-7113
dc.identifier.lattes2114570774349859
dc.identifier.urihttp://hdl.handle.net/11449/7438
dc.identifier.wosWOS:000276832000005
dc.language.isoeng
dc.publisherElsevier Gmbh, Urban & Fischer Verlag
dc.relation.ispartofPhytomedicine
dc.relation.ispartofjcr3.610
dc.relation.ispartofsjr1,087
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMycobacterium tuberculosisen
dc.subjectLichensen
dc.subjectPhenolic products derivativesen
dc.subjectTuberculostatic activityen
dc.subjectDiffractaic aciden
dc.titleAntimycobacterial activity of lichen substancesen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier Gmbh, Urban & Fischer Verlag
unesp.author.lattes2114570774349859
unesp.author.orcid0000-0002-6969-3963[2]
unesp.author.orcid0000-0001-6864-6092[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas