Metabolomic- and Molecular Networking-Based Exploration of the Chemical Responses Induced in Citrus sinensis Leaves Inoculated with Xanthomonas citri

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dc.contributor.authorSaldanha, Luiz Leonardo
dc.contributor.authorAllard, Pierre-Marie
dc.contributor.authorDilarri, Guilherme
dc.contributor.authorCodesido, Santiago
dc.contributor.authorGonzález-Ruiz, Víctor
dc.contributor.authorQueiroz, Emerson Ferreira
dc.contributor.authorFerreira, Henrique
dc.contributor.authorWolfender, Jean-Luc
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversity of Geneva
dc.contributor.institutionUniversity of Fribourg
dc.date.accessioned2023-07-29T13:59:40Z
dc.date.available2023-07-29T13:59:40Z
dc.date.issued2022-11-23
dc.description.abstractCitrus canker, caused by the bacterium Xanthomonas citri subsp. citri (X. citri), is a plant disease affecting Citrus crops worldwide. However, little is known about defense compounds in Citrus. Here, we conducted a mass spectrometry-based metabolomic approach to obtain an overview of the chemical responses of Citrus leaves to X. citri infection. To facilitate result interpretation, the multivariate analyses were combined with molecular networking to identify biomarkers. Metabolite variations among untreated and X. citri-inoculated Citrus samples under greenhouse conditions highlighted induced defense biomarkers. Notably, the plant tryptophan metabolism pathway was activated, leading to the accumulation of N-methylated tryptamine derivatives. This finding was subsequently confirmed in symptomatic leaves in the field. Several tryptamine derivatives showed inhibitory effects in vitro against X. citri. This approach has enabled the identification of new chemically related biomarker groups and their dynamics in the response of Citrus leaves to Xanthomonas infection.en
dc.description.affiliationBiochemistry Building Department of General and Applied Biology Institute of Biosciences State University of São Paulo, Rio Claro
dc.description.affiliationInstitute of Pharmaceutical Sciences of Western Switzerland University of Geneva
dc.description.affiliationSchool of Pharmaceutical Sciences University of Geneva
dc.description.affiliationDepartement of Biology University of Fribourg
dc.format.extent14693-14705
dc.identifierhttp://dx.doi.org/10.1021/acs.jafc.2c05156
dc.identifier.citationJournal of Agricultural and Food Chemistry, v. 70, n. 46, p. 14693-14705, 2022.
dc.identifier.doi10.1021/acs.jafc.2c05156
dc.identifier.issn1520-5118
dc.identifier.issn0021-8561
dc.identifier.scopus2-s2.0-85141941548
dc.identifier.urihttp://hdl.handle.net/11449/249001
dc.language.isoeng
dc.relation.ispartofJournal of Agricultural and Food Chemistry
dc.sourceScopus
dc.subjectbiotic stress
dc.subjectcitrus canker
dc.subjectpathogen-induced metabolites
dc.subjectsweet orange
dc.subjecttryptamines
dc.titleMetabolomic- and Molecular Networking-Based Exploration of the Chemical Responses Induced in Citrus sinensis Leaves Inoculated with Xanthomonas citrien
dc.typeArtigo
unesp.author.orcid0000-0003-2454-067X 0000-0003-2454-067X 0000-0003-2454-067X[1]
unesp.author.orcid0000-0003-3389-2191 0000-0003-3389-2191 0000-0003-3389-2191[2]
unesp.author.orcid0000-0001-7204-2363 0000-0001-7204-2363[5]
unesp.author.orcid0000-0001-9567-1664 0000-0001-9567-1664[6]
unesp.author.orcid0000-0002-9183-9420[7]
unesp.author.orcid0000-0002-0125-952X 0000-0002-0125-952X[8]

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