Rosmarinus officinalis extract-loaded emulgel prevents UVB irradiation damage to the skin

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dc.contributor.authorTakayama, Kátia S.
dc.contributor.authorMonteiro, Mariana C.
dc.contributor.authorSaito, Priscila
dc.contributor.authorPinto, Ingrid C.
dc.contributor.authorNakano, Claudia T.
dc.contributor.authorMartinez, Renata M.
dc.contributor.authorThomaz, Douglas V.
dc.contributor.authorVerri, Waldiceu A.
dc.contributor.authorBaracat, Marcela M.
dc.contributor.authorArakawa, Nilton S.
dc.contributor.authorRusso, Helena M. [UNESP]
dc.contributor.authorZeraik, Maria L.
dc.contributor.authorCasagrande, Rubia
dc.contributor.authorDo Couto, Renê O.
dc.contributor.authorGeorgetti, Sandra Regina
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionLaboratório de Desenvolvimento Farmacotécnico-LADEF
dc.date.accessioned2023-07-29T13:31:44Z
dc.date.available2023-07-29T13:31:44Z
dc.date.issued2022-01-01
dc.description.abstractUVB-irradiation increases the risk of various skin disorders, therefore leading to inflammation and oxidative stress. In this sense, antioxidant-rich herbs such as Rosmarinus officinalis may be useful in minimizing the damage promoted by reactive oxygen species. In this work, we report the efficacy of a R. officinalis hydroethanolic extract (ROe)-loaded emulgel in preventing UVB-related skin damage. Total phenols were determined using Folin-Ciocalteu assay, and the main phytocomponents in the extract were identified by UHPLC-HRMS. Moreover, in vitro sun protection factor (SPF) value of ROe was also assessed, and we investigated the in vivo protective effect of an emulgel containing ROe against UVB-induced damage in an animal model. The ROe exhibited commercially viable SPF activity (7.56 ± 0.16) and remarkable polyphenolic content (24.15 ± 0.11 mg (Eq.GA)/g). HPLC-MS and UHPLC-HRMS results showcased that the main compounds in ROe were: rosmarinic acid, carnosic acid and carnosol. The evaluation of the in vitro antioxidant activity demonstrated a dose-dependent effect of ROe against several radicals and the capacity to reduce iron. Therefore, we demonstrated that topical application of the formulation containing ROe inhibited edema formation, myeloperoxidase activity, GSH depletion and maintained ferric reducing (FRAP) and ABTS scavenging abilities of the skin after UVB exposure.en
dc.description.affiliationUniversidade Estadual de Londrina-UEL Departamento de Ciências Farmacêuticas, Avenida Robert Koch, 60, Hospital Universitário, PR
dc.description.affiliationUniversidade Federal de Goiás Faculdade de Farmácia, Rua 240, s/n, Setor Leste Universitário, GO
dc.description.affiliationUniversidade Estadual de Londrina-UEL Departamento de Patologia, Rodovia Celso Garcia Cid, Km 380, PR 445, Caixa Postal 10011, PR
dc.description.affiliationUniversidade Estadual Paulista-UNESP Instituto de Química Núcleos de Bioensaios Biossíntese e Ecofisiologia de Produtos Naturais-NuBBE Departamento de Química Orgânica, Avenida Prof. Francisco Degni, 55, SP
dc.description.affiliationUniversidade Estadual de Londrina – UEL Laboratório de Fitoquímica e Biomoléculas-LabFitoBio Departamento de Química, Rodovia Celso Garcia Cid, Km 380, PR
dc.description.affiliationUniversidade Federal de São João del-Rei Laboratório de Desenvolvimento Farmacotécnico-LADEF, Campus Centro-Oeste Dona Lindu, Rua Sebastião Gonçalves Coelho, MG
dc.description.affiliationUnespUniversidade Estadual Paulista-UNESP Instituto de Química Núcleos de Bioensaios Biossíntese e Ecofisiologia de Produtos Naturais-NuBBE Departamento de Química Orgânica, Avenida Prof. Francisco Degni, 55, SP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdCNPq: 307186/2017-2
dc.description.sponsorshipIdCNPq: 307852/2019-9
dc.identifierhttp://dx.doi.org/10.1590/0001-3765202220201058
dc.identifier.citationAnais da Academia Brasileira de Ciencias, v. 94, n. 4, 2022.
dc.identifier.doi10.1590/0001-3765202220201058
dc.identifier.issn1678-2690
dc.identifier.issn0001-3765
dc.identifier.scopus2-s2.0-85143569527
dc.identifier.urihttp://hdl.handle.net/11449/248003
dc.language.isoeng
dc.relation.ispartofAnais da Academia Brasileira de Ciencias
dc.sourceScopus
dc.subjectAntioxidants
dc.subjectcosmeceuticals
dc.subjectdermatology
dc.subjectphytochemicals
dc.subjectsunscreens
dc.titleRosmarinus officinalis extract-loaded emulgel prevents UVB irradiation damage to the skinen
dc.typeArtigo
unesp.author.orcid0000-0003-2602-6930[1]
unesp.author.orcid0000-0002-2171-4200[2]
unesp.author.orcid0000-0002-8002-0559[3]
unesp.author.orcid0000-0002-5983-0960[4]
unesp.author.orcid0000-0003-1689-6932[5]
unesp.author.orcid0000-0003-1096-0876[6]
unesp.author.orcid0000-0003-0000-3466[7]
unesp.author.orcid0000-0003-2756-9283[8]
unesp.author.orcid0000-0002-7109-7191[9]
unesp.author.orcid0000-0002-0325-1660[10]
unesp.author.orcid0000-0002-4961-2353[11]
unesp.author.orcid0000-0002-0559-8502[12]
unesp.author.orcid0000-0002-2296-1668[13]
unesp.author.orcid0000-0002-3748-3427[14]
unesp.author.orcid0000-0003-2580-8762[15]

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