Serotonergic mechanisms of the lateral parabrachial nucleus in renal and hormonal responses to isotonic blood volume expansion

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dc.contributor.authorMargatho, Lisandra Oliveira
dc.contributor.authorGiusti-Paiva, Alexandre
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorElias, Lucila Leico Kagohara
dc.contributor.authorVivas, Laura M.
dc.contributor.authorAntunes-Rodrigues, Jose
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Invest Med M&M Ferreyra
dc.date.accessioned2014-05-20T15:20:27Z
dc.date.available2014-05-20T15:20:27Z
dc.date.issued2007-03-01
dc.description.abstractThis study investigated the involvement of serotonergic mechanisms of the lateral parabrachial nucleus (LPBN) in the control of sodium (Na+) excretion, potassium (K+) excretion, and urinary volume in unanesthetized rats subjected to acute isotonic blood volume expansion (0.15 M NaCl, 2 ml/100 g of body wt over 1 min) or control rats. Plasma oxytocin (OT), vasopressin (VP), and atrial natriuretic peptide (ANP) levels were also determined in the same protocol. Male Wistar rats with stainless steel cannulas implanted bilaterally into the LPBN were used. In rats treated with vehicle in the LPBN, blood volume expansion increased urinary volume, Na+ and K+ excretion, and also plasma ANP and OT. Bilateral injections of serotonergic receptor antagonist methysergide (1 or 4 mu g/200 eta 1) into the LPBN reduced the effects of blood volume expansion on increased Na+ and K+ excretion and urinary volume, while LPBN injections of serotonergic 5-HT2a/HT2c receptor agonist, 2.5-dimetoxi-4-iodoamphetamine hydrobromide (DOI;1 or 5 mu g/200 eta 1) enhanced the effects of blood volume expansion on Na+ and K+ excretion and urinary volume. Methysergide (4 mu g) into the LPBN decreased the effects of blood volume expansion on plasma ANP and OT, while DOI (5 mu g) increased them. The present results suggest the involvement of LPBN serotonergic mechanisms in the regulation of urinary sodium, potassium and water excretion, and hormonal responses to acute isotonic blood volume expansion.en
dc.description.affiliationUniv São Paulo, Dept Physiol, Sch Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationPaulista State Univ, Sch Dent, Dept Physiol & Pathol, São Paulo, Brazil
dc.description.affiliationInst Invest Med M&M Ferreyra, Cordoba, Argentina
dc.description.affiliationUnespPaulista State Univ, Sch Dent, Dept Physiol & Pathol, São Paulo, Brazil
dc.format.extentR1190-R1197
dc.identifierhttp://dx.doi.org/10.1152/ajpregu.00351.2006
dc.identifier.citationAmerican Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 292, n. 3, p. R1190-R1197, 2007.
dc.identifier.doi10.1152/ajpregu.00351.2006
dc.identifier.issn0363-6119
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/31750
dc.identifier.wosWOS:000244722100017
dc.language.isoeng
dc.publisherAmer Physiological Soc
dc.relation.ispartofAmerican Journal of Physiology: Regulatory Integrative and Comparative Physiology
dc.relation.ispartofjcr3.082
dc.relation.ispartofsjr1,550
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectserotoninpt
dc.subjectnatriuresispt
dc.subjectatrial natriuretic peptidept
dc.subjectoxytocinpt
dc.subjectvasopressinpt
dc.titleSerotonergic mechanisms of the lateral parabrachial nucleus in renal and hormonal responses to isotonic blood volume expansionen
dc.typeArtigo
dcterms.licensehttp://www.the-aps.org/mm/Publications/Info-For-Authors/Copyright
dcterms.rightsHolderAmer Physiological Soc
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0003-1167-4441[3]
unesp.author.orcid0000-0001-5059-9988[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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