In vitro and in vivo investigation of the biological and mechanical behaviour of resin-modified glass-ionomer cement containing chlorhexidine

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dc.contributor.authorDe Castilho, Aline Rogéria Freire
dc.contributor.authorDuque, Cristiane [UNESP]
dc.contributor.authorNegrini, Thaís de Cássia [UNESP]
dc.contributor.authorSacono, Nancy Tomoko [UNESP]
dc.contributor.authorDe Paula, Andréia Bolzan
dc.contributor.authorCosta, Carlos Alberto de Souza [UNESP]
dc.contributor.authorSpolidório, Denise Madalena Palomari [UNESP]
dc.contributor.authorPuppin-Rontani, Regina Maria
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:28:18Z
dc.date.available2014-05-27T11:28:18Z
dc.date.issued2013-02-01
dc.description.abstractObjectives: To evaluate: (1) the in vitro antibacterial, cytotoxic and mechanical properties of a resin-modified glass ionomer cement (RMGIC) containing different concentrations of chlorhexidine (CHX) and (2) the in vivo microbiologic action of the best concentration of CHX associated with the RMGIC applied on remaining dentine after indirect pulp treatment (IPT). Methods: For the in vitro studies, RMGIC was associated with 0.2, 0.5, 1.25 and 2.5% CHX. Microbiologic evaluation consisted of an agar diffusion test on cariogenic bacteria for 24 h. Odontoblast-like cell metabolism and morphology analyses measured the cytotoxic effects of the RMGIC groups after 24 h. The same groups were submitted to compressive and diametral tensile strength. The in vivo treatment consisted of IPT using an RMGIC associated with the best CHX concentration. Clinical and microbiologic evaluations were performed before and after 3 months. Results: The use of 1.25% CHX significantly improved the antibacterial effects of the evaluated RMGIC, without causing any detrimental effects to the odontoblast-like cells and on the mechanical properties. This RMGIC and CHX combination completely eliminated mutans streptococci after 3 months of IPT. Conclusion: The RMGIC and 1.25% CHX mixture showed great biological and mechanical behaviour and could be a good treatment against caries progression. Clinical significance: The association of CHX with a liner RMGIC opens a new perspective for arresting residual caries after IPT. © 2012 Elsevier Ltd. All rights reserved.en
dc.description.affiliationDepartment of Pediatric Dentistry Piracicaba Dental School University of Campinas (UNICAMP), P.O. Box 52, 13414-903 Piracicaba, SP
dc.description.affiliationDepartment of Pediatric Dentistry Araçatuba School of Dentistry University of São Paulo State (UNESP), Araçatuba, São Paulo
dc.description.affiliationDepartment of Clinical Analysis Araraquara School of Pharmacy University of São Paulo State (UNESP), Araraquara, São Paulo
dc.description.affiliationDepartment of Physiology and Pathology Araraquara School of Dentistry University of São Paulo State (UNESP), Araraquara, São Paulo
dc.description.affiliationDepartment of Dental Materials Piracicaba Dental School University of Campinas (UNICAMP), Piracicaba, São Paulo
dc.description.affiliationUnespDepartment of Pediatric Dentistry Araçatuba School of Dentistry University of São Paulo State (UNESP), Araçatuba, São Paulo
dc.description.affiliationUnespDepartment of Clinical Analysis Araraquara School of Pharmacy University of São Paulo State (UNESP), Araraquara, São Paulo
dc.description.affiliationUnespDepartment of Physiology and Pathology Araraquara School of Dentistry University of São Paulo State (UNESP), Araraquara, São Paulo
dc.format.extent155-163
dc.identifierhttp://dx.doi.org/10.1016/j.jdent.2012.10.014
dc.identifier.citationJournal of Dentistry, v. 41, n. 2, p. 155-163, 2013.
dc.identifier.doi10.1016/j.jdent.2012.10.014
dc.identifier.file2-s2.0-84873741284.pdf
dc.identifier.issn0300-5712
dc.identifier.lattes5651874509493617
dc.identifier.orcid0000-0002-2575-279X
dc.identifier.scopus2-s2.0-84873741284
dc.identifier.urihttp://hdl.handle.net/11449/74472
dc.identifier.wosWOS:000314876000009
dc.language.isoeng
dc.relation.ispartofJournal of Dentistry
dc.relation.ispartofjcr3.770
dc.relation.ispartofsjr1,919
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntibacterial activity
dc.subjectCell culture
dc.subjectChlorhexidine digluconate
dc.subjectGlass ionomer cement
dc.subjectIndirect pulp therapy
dc.subjectMechanical properties
dc.titleIn vitro and in vivo investigation of the biological and mechanical behaviour of resin-modified glass-ionomer cement containing chlorhexidineen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes4517484241515548[6]
unesp.author.lattes5651874509493617[2]
unesp.author.orcid0000-0003-2376-1024[7]
unesp.author.orcid0000-0002-7455-6867[6]
unesp.author.orcid0000-0002-2575-279X[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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Artigos - Odontologia Infantil e Social - FOA
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