Expression of metallothionein in pleomorphic adenoma

dc.contributor.authorRibeiro Ribeiro, André Luis
dc.contributor.authorDe Melo Alves, Sérgio
dc.contributor.authorMonteiro Carneiro, Nayara Cristina
dc.contributor.authorMarques, Yonara Maria Freire Soares [UNESP]
dc.contributor.authorde Jesus Viana Pinheiro, João
dc.contributor.authorDos Santos Pinto, Décio
dc.contributor.institutionUniversidade Federal do Pará (UFPA)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T16:39:17Z
dc.date.available2018-12-11T16:39:17Z
dc.date.issued2015-01-01
dc.description.abstractPurpose: Pleomorphic adenoma (PA) is a benign salivary gland tumor (SGT) containing different cell types, including myoepithelial cells. Metallothionein (MT) is a protein that has multiple functions in various neoplasm and it is associated with a worse prognosis in cancer. This study aimed to evaluate the immunoexpression of MT in PA. Methods: The expression of MT was assessed by immunohistochemistry in 13 cases of PA. The labeled cells were counted and analyzed. Results: All PA samples showed MT expression with an average rate of positive cells of 12.29%. A higher expression of MT was observed in myoepithelial cells, with both cytoplasmic and nuclear labeling. These results drove us the conclusion that PA expresses MT at low levels. MT was present in the nucleus and cytoplasm of neoplasticen
dc.description.affiliationDepartment of Oral and Maxillofacial Surgery, School of Dentistry, University Center of Pará-CESUPA
dc.description.affiliationDepartment of Oral Pathology, School of Dentistry, Federal University of Pará-UFPA
dc.description.affiliationDepartment of Oral Pathology, School of Dentistry, São Paulo State University Julio de Mesquita Filho - UNESP
dc.description.affiliationDepartment of Oral Pathology, School of Dentistry, University of Sao Paulo
dc.description.affiliationUnespDepartment of Oral Pathology, School of Dentistry, São Paulo State University Julio de Mesquita Filho - UNESP
dc.format.extent21-31
dc.identifier.citationInternational Journal of Clinical Dentistry, v. 8, n. 1, p. 21-31, 2015.
dc.identifier.issn1939-5833
dc.identifier.scopus2-s2.0-84942052082
dc.identifier.urihttp://hdl.handle.net/11449/168028
dc.language.isoeng
dc.relation.ispartofInternational Journal of Clinical Dentistry
dc.relation.ispartofsjr0,107
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectMetallothionein
dc.subjectMyoepithelial cell
dc.subjectPleomorphic adenoma
dc.subjectSalivary gland tumor
dc.titleExpression of metallothionein in pleomorphic adenomaen
dc.typeArtigo

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