Smoking Intensity Increases Diaphragm Muscle Injury: A Clinicopathologic Study

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dc.contributor.authorNucci, Ricardo Aparecido Baptista
dc.contributor.authorBusse, Alexandre Leopold
dc.contributor.authorde Souza, Romeu Rodrigues
dc.contributor.authorMaifrino, Laura Beatriz Mesiano
dc.contributor.authorPasqualucci, Carlos Augusto
dc.contributor.authorAnaruma, Carlos Alberto [UNESP]
dc.contributor.authorLeite, Renata Elaine Paraizo
dc.contributor.authorRodriguez, Roberta Diehl
dc.contributor.authorSuemoto, Claudia Kimie
dc.contributor.authorJacob-Filho, Wilson
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institution9 de Julho University—UNINOVE
dc.contributor.institutionFaculty of Medicine of the ABC District
dc.contributor.institutionDante Pazzanese Institute of Cardiology
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T16:16:26Z
dc.date.available2023-07-29T16:16:26Z
dc.date.issued2023-06-01
dc.description.abstractBackground: Studying the effects of smoking intensity is important to evaluate the risk of tobacco use on a range of illnesses, such as as sarcopenia among the elderly. Thus, this study aimed to analyze the effects of pack-years of cigarette smoking on the diaphragm muscle (DIAm) histopathology of postmortem samples. Methods: Subjects were divided into three groups: never-smoker (n = 46); less than 30 pack-years of smoking (n = 12); and more than 30 pack-years of smoking (n = 30). Diaphragm samples were stained with Picrosirius red and hematoxylin and eosin stain for general structure. Results: Participants with more than 30 pack-years of cigarette smoking had a significant increase in adipocytes, blood vessels and collagen deposit, as well as an increase in histopathological alterations. Conclusions: Pack-years of smoking was associated with DIAm injury. However, further clinicopathological studies are needed to confirm our findings.en
dc.description.affiliationDepartment of Pathology Faculty of Medicine University of São Paulo
dc.description.affiliationLaboratory of Medical Research in Aging (LIM-66) Division of Geriatrics Faculty of Medicine University of São Paulo
dc.description.affiliationDepartment of Anatomy Institute of Biomedical Sciences University of São Paulo
dc.description.affiliationDepartment of Anatomy 9 de Julho University—UNINOVE
dc.description.affiliationLaboratory of Clinical Analysis Faculty of Medicine of the ABC District
dc.description.affiliationDante Pazzanese Institute of Cardiology
dc.description.affiliationLaboratory of Morphology and Physical Activity Department of Physical Education São Paulo State University “Júlio de Mesquita Filho”
dc.description.affiliationLaboratory of Physiopathology in Aging (LIM-22) Department of Pathology Faculty of Medicine University of Sao Paulo
dc.description.affiliationUnespLaboratory of Morphology and Physical Activity Department of Physical Education São Paulo State University “Júlio de Mesquita Filho”
dc.identifierhttp://dx.doi.org/10.3390/jcm12113823
dc.identifier.citationJournal of Clinical Medicine, v. 12, n. 11, 2023.
dc.identifier.doi10.3390/jcm12113823
dc.identifier.issn2077-0383
dc.identifier.scopus2-s2.0-85161582690
dc.identifier.urihttp://hdl.handle.net/11449/250050
dc.language.isoeng
dc.relation.ispartofJournal of Clinical Medicine
dc.sourceScopus
dc.subjectautopsy
dc.subjectcigarette
dc.subjectdiaphragm
dc.subjecthistopathology
dc.titleSmoking Intensity Increases Diaphragm Muscle Injury: A Clinicopathologic Studyen
dc.typeArtigo
unesp.author.orcid0000-0001-5649-2145[1]
unesp.author.orcid0000-0002-6709-2216[2]

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