Study of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames test

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dc.contributor.authorde Morandim-Giannetti, Andreia A. [UNESP]
dc.contributor.authorCotinguiba, Fernando [UNESP]
dc.contributor.authorRegasini, Luis O. [UNESP]
dc.contributor.authorFrigieri, Mariana C. [UNESP]
dc.contributor.authorVaranda, Eliana A. [UNESP]
dc.contributor.authorCoqueiro, Aline [UNESP]
dc.contributor.authorKato, Massuo J.
dc.contributor.authorBolzani, Vanderlan S. [UNESP]
dc.contributor.authorFurlan, Maysa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionCentro Universitário da FEI
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-28T22:48:46Z
dc.date.available2022-04-28T22:48:46Z
dc.date.issued2011-06-15
dc.description.abstractPhytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (Z)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound. © 2011 Academic Journals.en
dc.description.affiliationDepartamento de Química Orgânica Instituto de Química Universidade Estadual de São Paulo, Rua Francisco Degni, s/n, 14800-900 Araraquara-SP
dc.description.affiliationDepartamento de Engenharia Química Centro Universitário da FEI, Av. Humberto de Alencar Castelo Branco, 3972, 09850-901 São Bernardo do Campo-SP
dc.description.affiliationDepartamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, Rodovia Araraquara/Jaú Km 1, 14801-902 Araraquara-SP
dc.description.affiliationDepartamento de Química Fundamental Instituto de Química Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, 05508-000, São Paulo-SP
dc.description.affiliationUnespDepartamento de Química Orgânica Instituto de Química Universidade Estadual de São Paulo, Rua Francisco Degni, s/n, 14800-900 Araraquara-SP
dc.description.affiliationUnespDepartamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, Rodovia Araraquara/Jaú Km 1, 14801-902 Araraquara-SP
dc.format.extent5398-5401
dc.identifier.citationAfrican Journal of Biotechnology, v. 10, n. 27, p. 5398-5401, 2011.
dc.identifier.issn1684-5315
dc.identifier.scopus2-s2.0-79959357732
dc.identifier.urihttp://hdl.handle.net/11449/226393
dc.language.isoeng
dc.relation.ispartofAfrican Journal of Biotechnology
dc.sourceScopus
dc.subject(z)-piplartine
dc.subjectAmes test
dc.subjectMutagenic activated
dc.subjectPiper tuberculatum
dc.subjectPiperaceae
dc.titleStudy of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames testen
dc.typeArtigo
unesp.departmentCiências Biológicas - FCFpt

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Artigos - Química Orgânica - IQ
Araraquara - FCF - Faculdade de Ciências Farmacêuticas