Study of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames test
dc.contributor.author | de Morandim-Giannetti, Andreia A. [UNESP] | |
dc.contributor.author | Cotinguiba, Fernando [UNESP] | |
dc.contributor.author | Regasini, Luis O. [UNESP] | |
dc.contributor.author | Frigieri, Mariana C. [UNESP] | |
dc.contributor.author | Varanda, Eliana A. [UNESP] | |
dc.contributor.author | Coqueiro, Aline [UNESP] | |
dc.contributor.author | Kato, Massuo J. | |
dc.contributor.author | Bolzani, Vanderlan S. [UNESP] | |
dc.contributor.author | Furlan, Maysa [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | Centro Universitário da FEI | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.date.accessioned | 2022-04-28T22:48:46Z | |
dc.date.available | 2022-04-28T22:48:46Z | |
dc.date.issued | 2011-06-15 | |
dc.description.abstract | Phytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (Z)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound. © 2011 Academic Journals. | en |
dc.description.affiliation | Departamento de Química Orgânica Instituto de Química Universidade Estadual de São Paulo, Rua Francisco Degni, s/n, 14800-900 Araraquara-SP | |
dc.description.affiliation | Departamento de Engenharia Química Centro Universitário da FEI, Av. Humberto de Alencar Castelo Branco, 3972, 09850-901 São Bernardo do Campo-SP | |
dc.description.affiliation | Departamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, Rodovia Araraquara/Jaú Km 1, 14801-902 Araraquara-SP | |
dc.description.affiliation | Departamento de Química Fundamental Instituto de Química Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, 05508-000, São Paulo-SP | |
dc.description.affiliationUnesp | Departamento de Química Orgânica Instituto de Química Universidade Estadual de São Paulo, Rua Francisco Degni, s/n, 14800-900 Araraquara-SP | |
dc.description.affiliationUnesp | Departamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, Rodovia Araraquara/Jaú Km 1, 14801-902 Araraquara-SP | |
dc.format.extent | 5398-5401 | |
dc.identifier.citation | African Journal of Biotechnology, v. 10, n. 27, p. 5398-5401, 2011. | |
dc.identifier.issn | 1684-5315 | |
dc.identifier.scopus | 2-s2.0-79959357732 | |
dc.identifier.uri | http://hdl.handle.net/11449/226393 | |
dc.language.iso | eng | |
dc.relation.ispartof | African Journal of Biotechnology | |
dc.source | Scopus | |
dc.subject | (z)-piplartine | |
dc.subject | Ames test | |
dc.subject | Mutagenic activated | |
dc.subject | Piper tuberculatum | |
dc.subject | Piperaceae | |
dc.title | Study of salmonella typhimurium mutagenicity assay of (z)-piplartine by the ames test | en |
dc.type | Artigo | |
unesp.department | Ciências Biológicas - FCF | pt |