Trypanocidal tetrahydrofuran lignans from Peperomia blanda

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Data

2008-01-01

Autores

Felippe, Lidiane Gaspareto [UNESP]
Baldoqui, Debora Cristina [UNESP]
Kato, Massuo Jorge
Bolzani, Vanderlan da Silva [UNESP]
Guimaraes, Elsie Franklin
Cicarelli, Regina Maria Barreto [UNESP]
Furlan, Maysa [UNESP]

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Editor

Pergamon-Elsevier B.V. Ltd

Resumo

Five tetrahydrofuran lignans and two known flavones were isolated from the aerial parts of Peperomia blanda. The structures of the isolated lignans were elucidated by interpretation of their spectroscopic data, including by gHMQC and gHMBC. The relative and absolute configurations of the isolates were determined from NOESY interactions and optical properties, respectively. Four of the lignans were diastercomeric whilst one was of mixed biosynthetic origin. All but one of the lignans exhibited high in vitro trypanocidal activity when assayed against epimastigotes of Trypanosoma cruzi strain Y. (C) 2007 Elsevier Ltd. All rights reserved.

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Palavras-chave

Peperomia blanda, Piperaceae, tetrahydrofuran lignans, structural elucidation, trypanocidal activity

Como citar

Phytochemistry. Oxford: Pergamon-Elsevier B.V. Ltd, v. 69, n. 2, p. 445-450, 2008.